DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IKKepsilon and TBK1

DIOPT Version :9

Sequence 1:	NP_610048.2	Gene:	IKKepsilon / 35329	FlyBaseID:	FBgn0086657	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_037386.1	Gene:	TBK1 / 29110	HGNCID:	11584	Length:	729	Species:	Homo sapiens

Alignment Length:	762	Identity:	274/762 - (35%)
Similarity:	430/762 - (56%)	Gaps:	90/762 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LRGSVSYVWCTTSVLGKGATGSVFQGVNKITGESVAVKTFNPYSHMRPADVQMREFEALKKVNHE 68
            ::.:.:::|..:.:||:|||.:||:|.:|.||:..|:|.||..|.:||.||||||||.|||:||:
Human     1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHK 65

  Fly    69 NIVKLLAIEEDQEGRGKVIVMELCTGGSLFNILDDPENSYGLPEHEFLLVLEHLCAGMKHLRDNK 133
            |||||.||||:...|.||::||.|..|||:.:|::|.|:|||||.|||:||..:..||.|||:|.
Human    66 NIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130

  Fly   134 LVHRDLKPGNIMKFISEDGQTIYKLTDFGAARELEDNQPFASLYGTEEYLHPDLYERAVLRKSIQ 198
            :||||:||||||:.|.||||::||||||||||||||::.|.||||||||||||:||||||||..|
Human   131 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQ 195

  Fly   199 RSFTANVDLWSIGVTLYHVATGNLPFRPF-GGRKNRETMHQITTKKASGVISGTQLSENGPIEWS 262
            :.:.|.|||||||||.||.|||:|||||| |.|:|:|.|::|.|.|.||.|||.|.:|||||:||
Human   196 KKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWS 260

  Fly   263 TTLPPHAHLSQGLKTLVTPLLAGLLEENREKTWSFDRFFHEVTLILRKRVIHVFFTNRTSSVEVF 327
            ..:|....||:||:.|:||:||.:||.::||.|.||:||.|.:.||.:.|||||...:.::.:::
Human   261 GDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIY 325

  Fly   328 LEPDEQIDNFRERIFLQTEVPLEKQILLFNNEHLEKKVTPRTIAKAFPATTTDQPIFLYSNDDNN 392
            :........|.|.::.||::....|.|::....|  .:.|..:|:.||.||.:.|||:.|.:..|
Human   326 IHSYNTATIFHELVYKQTKIISSNQELIYEGRRL--VLEPGRLAQHFPKTTEENPIFVVSREPLN 388

  Fly   393 V--QLPQQLDLPKFPVFPPNVSVENDASLAKSACSVGHECKRRVDIFTSMDILIKKGVEHFIEML 455
            .  .:.:::.|||   ..|...::.|||:||:...|.....|..........|::||:...||::
Human   389 TIGLIYEKISLPK---VHPRYDLDGDASMAKAITGVVCYACRIASTLLLYQELMRKGIRWLIELI 450

  Fly   456 --------------VTTITLLLKKTES----FDNLLSTVIDYADV-----VHS-MARVTKGDQEI 496
                          |.|:...::..|.    ::.|:...::.|::     :|: :.|::.....|
Human   451 KDDYNETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTI 515

  Fly   497 KTLLTALENVKSDFDGAADVISQMHKHFVIDDELNDQWTSSMHGKKCPCKTRASAQAKYLVERLR 561
            :|.|             .|:.|::..    ...|.|.|.   |.:....|.|...:.:.|:..:.
Human   516 ETSL-------------QDIDSRLSP----GGSLADAWA---HQEGTHPKDRNVEKLQVLLNCMT 560

  Fly   562 DSWQHLLRDRATRTLTYNDEQFHALEKIKVDHNGKRIKALLLDNVNPTVAQIAECL--------- 617
            :.:....:|:|.|.|.||:||.|..:|.|:.::..:......|          ||:
Human   561 EIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTHFTD----------ECVKKYEAFLNK 615

  Fly   618 -ADWYKLAQTVYLKTQIL---------EKDVRDCERKLNGIRD----ELYHVKSELKLDVDTKTI 668
             .:|  :.:.::|:.|:|         |::|...:...|.:::    :::...|.:|..: |...
Human   616 SEEW--IRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQKMFTASSGIKHTM-TPIY 677

  Fly   669 NNNNQLAKIEERNRLRVMQQQQQEVMAVMRTNSDIISLLSKLGITNG 715
            .::|.|  :|....::.::::.:.|:..:..|:.|:.....|.:..|
Human   678 PSSNTL--VEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMDGG 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IKKepsilon	NP_610048.2	Pkinase	16..297	CDD:278497	176/281 (63%)
		STKc_TBK1	18..332	CDD:270890	188/314 (60%)
		UBL_TBK1_like	299..389	CDD:240618	27/89 (30%)
TBK1	NP_037386.1	S_TKc	9..242	CDD:214567	148/232 (64%)
		STKc_TBK1	15..330	CDD:270890	188/314 (60%)
		UBL_TBK1_like	297..385	CDD:240618	27/89 (30%)
		Interaction with AZI2, TANK and TBKBP1. /evidence=ECO:0000269\|PubMed:21931631	621..729		17/105 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156301
Domainoid	1	1.000	302	1.000	Domainoid score	I1399
eggNOG	1	0.900	-	-		E2759_KOG4250
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22742
Inparanoid	1	1.050	467	1.000	Inparanoid score	I1543
Isobase	1	0.950	-	0	Normalized mean entropy	S3798
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D257949at33208
OrthoFinder	1	1.000	-	-		FOG0002906
OrthoInspector	1	1.000	-	-		otm41602
orthoMCL	1	0.900	-	-		OOG6_105248
Panther	1	1.100	-	-	O	PTHR22969
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5178
SonicParanoid	1	1.000	-	-		X2267
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.780