Protein Alignment IKKepsilon and ikke-1

DIOPT Version :10

• Sequence 1: NP_610048.2
• Gene: IKKepsilon / 35329
• FlyBaseID: FBgn0086657
• Length: 720
• Species: Drosophila melanogaster
• Sequence 2: NP_871627.1
• Gene: ikke-1 / 176278
• WormBaseID: WBGene00011299
• Length: 820
• Species: Caenorhabditis elegans
• Alignment Length: 741
• Identity: 165/741 - (22%)
• Similarity: 282/741 - (38%)
• Gaps: 159/741 - (21%)

  Fly    18 LGKGATGSVFQGVNKITGESVAVKTFNPYSHMRPADVQMREFEALKKV-NHENIVKLLAIEEDQE 81
            :||||...|::|..: :|..|||||  ....:..|.:.: |.|.|||: ...|||:.......:.
 Worm    27 IGKGAYSEVYRGRTE-SGRLVAVKT--ACKKLEVAAIGI-EIEILKKLKGASNIVQYFGSNHTKM 87

  Fly    82 GRGKV------IVMELCTGGSLFNILDDPENSYGLPEHEFLLVLEHLCAGMKHLRDNKLVHRDLK 140
            ..|.|      ..||..: .||...:..|:|..||..:..:.::......:..||::.:.|||:|
 Worm    88 APGSVTSETISFAMEYAS-SSLEAEMRRPKNHRGLSSNALIDLVVDCSMALSALREHNIAHRDIK 151

  Fly   141 PGNIMKF-----ISEDGQTIYKLTDFGAARELEDN--QPFASLYGTEEYLHPDLYERAVLRKSIQ 198
            ..||:.|     .......::||.|.|.::.|.:|  ....:|.||...|||.|....|.....|
 Worm   152 HMNILLFPGTPTRGRRSTHLFKLCDMGCSKSLSENSSHEMRTLVGTPNLLHPFLAHEMVDPLMAQ 216

  Fly   199 R--------SFTA-NVDLWSIGVTLYHVATGNLPFRPFGGRKNRETMHQ--------------IT 240
            .        ::|: ..|||::|.|||..|||..||.  ..|.|:...|:              :.
 Worm   217 NRHNWKTKSAYTSEQCDLWALGCTLYFCATGKFPFE--HERNNKSLYHKAVVALTQNPDAIAMVL 279

  Fly   241 TKKASGVISGTQLSENGPIEWSTTLPPHAHLSQGLKTLVTPLLAGLLEENREKTWSFDRFFHEVT 305
            .:|.......|.:.|..|:   |.||  |..::..|.||:.:           |.....||||
 Worm   280 VQKGRDPGRRTDIFEFQPV---TELP--AKFTRYPKWLVSTM-----------TCLLRSFFHE-- 326

  Fly   306 LILRKRVIHVFFTNRTSSVEVFLEPDEQIDNFRERIFLQT-EVPLEKQILLFNNEHLEKKVTPRT 369
                            .|:|.:.:..:.:.|.:.|.|... ::.:.:...:.|..||...:...:
 Worm   327 ----------------PSIEYYAKVADAMRNSKRRTFSSVDQMSIVEHTDMSNVPHLGFSIPSIS 375

  Fly   370 IAKAFPATTTDQPIFLYSNDDNNVQLPQQLDLPKFP-----VFPPNVSVENDASLAKSACSVGHE 429
            ....:|..|   .|.|.||...:....:|..:...|     |.|....|:....||::.  ..||
 Worm   376 KCLGYPEGT---DILLLSNTSTHYLDSKQKSVDGLPDDLYLVVPQTSHVDMRKILARNI--EFHE 435

  Fly   430 CKRRVDIFTSMDILIKKGVEHFIEMLVTTITLLLKKTESFDNLLSTVIDYADVVHSMARVTKGDQ 494
            .....|...| :|.|||..|..  .::|.|...|...:....:|||  .::.:|..:::.    :
 Worm   436 FDDMTDRKLS-EIRIKKCYEGL--SMLTEIDEYLALFDRVSTILST--QFSLLVQELSQF----E 491

  Fly   495 EIKTLLTALENVKSDFDGAADVISQMHKHFVIDDELNDQWTSSMHGKKCPCKTRASAQAKYLVER 559
            .::|        .|.|....|:.|   ...::.||.|.:  :.|...:|      ..|||...|.
 Worm   492 RVQT--------ASRFAVYVDMAS---VPLMLFDEANPE--TKMISDQC------IQQAKRAREE 537

  Fly   560 LRDSWQHLLRDRATRTLTYNDEQFHALEKIKVDHNGKRI----KALLLDNVN-PTVAQIAECLAD 619
            |                     :.||...:.::...|::    :.|.|:::: |.:.:..|....
 Worm   538 L---------------------ERHAKVSMDIEACAKQLSKDAEDLRLEDMDLPGICEEIESYVF 581

  Fly   620 WYKLAQTVYLKTQILEKD-VRDCERKLNGIRDELYHVKSELKLDVDTKTINNNNQLAKIEERNRL 683
            :.|.|   .|.||...:: |..|.::.|.|.:::::....:......|.:|....|:::  |:..
 Worm   582 YDKQA---ILSTQKYSQELVELCLKRRNNIMEQIFNSPDRINKSKLNKAMNLAASLSQL--RSNY 641

  Fly   684 RVMQQQQQEVMAVMRTNSDIISLLSK 709
            |.:|..          .|:.:.||.|
 Worm   642 RKLQDM----------ISECVDLLEK 657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IKKepsilon	NP_610048.2	STKc_TBK1	18..332	CDD:270890	89/350 (25%)
		Ubl_TBK1_like	310..388	CDD:340518	12/78 (15%)
		TBK1_CCD1	405..656	CDD:465742	53/261 (20%)
ikke-1	NP_871627.1	Protein Kinases, catalytic domain	25..263	CDD:473864	70/242 (29%)