DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IKKepsilon and Ikbkb

DIOPT Version :9

Sequence 1:	NP_610048.2	Gene:	IKKepsilon / 35329	FlyBaseID:	FBgn0086657	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_001153246.1	Gene:	Ikbkb / 16150	MGIID:	1338071	Length:	757	Species:	Mus musculus

Alignment Length:	780	Identity:	170/780 - (21%)
Similarity:	306/780 - (39%)	Gaps:	191/780 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 WCTTSVLGKGATGSVFQGVNKITGESVAVKTFNPYSHMRPADVQMREFEALKKVNHENIVKLLAI 76
            |.....||.|..|:|.:..|:.|||.:|:|........:..|....|.:.::::||.|:|....:
Mouse    15 WEMKERLGTGGFGNVIRWHNQATGEQIAIKQCRQELSPKNRDRWCLEIQIMRRLNHPNVVAARDV 79

  Fly    77 EEDQEGRG----KVIVMELCTGGSLFNILDDPENSYGLPEHEFLLVLEHLCAGMKHLRDNKLVHR 137
            .|..:...    .::.||.|.||.|...|:..||..||.|...|.:|..:.:.:::|.:|:::||
Mouse    80 PEGMQNLAPNDLPLLAMEYCQGGDLRRYLNQFENCCGLREGAVLTLLSDIASALRYLHENRIIHR 144

  Fly   138 DLKPGNIMKFISEDGQ--TIYKLTDFGAARELEDNQPFASLYGTEEYLHPDLYERAVLRKSIQRS 200
            ||||.||   :.:.|:  .|:|:.|.|.|:||:......|..||.:||.|:|.|        |:.
Mouse   145 DLKPENI---VLQQGEKRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLE--------QQK 198

  Fly   201 FTANVDLWSIGVTLYHVATGNLPFRPFGGRKNRETMH-QITTKKASGVISGTQLSENGPIEWSTT 264
            :|..||.||.|...:...||   ||||.........| ::..|....::....|  ||.:::|::
Mouse   199 YTVTVDYWSFGTLAFECITG---FRPFLPNWQPVQWHSKVRQKSEVDIVVSEDL--NGAVKFSSS 258

  Fly   265 LPPHAHLSQGL-----KTLVTPLLAGLLEENREKTWSFDRFFHEVTLILRKRVIHVFFTNRTSSV 324
            ||...:|:..|     |.|...|:....:...:..:..:..|..:..||..:::|| ....|.:|
Mouse   259 LPFPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPQYGPNGCFRALDDILNLKLVHV-LNMVTGTV 322

  Fly   325 EVF-LEPDEQIDNFRERI-----FLQTEVPLEKQ------------------------------I 353
            ..: :..||.:.:.:.||     .|:|:..|.::                              :
Mouse   323 HTYPVTEDESLQSLKTRIQEDTGILETDQELLQEAGLVLLPDKPATQCISDSKTNEGLTLDMDLV 387

  Fly   354 LLFNNEHL--EKKVTPRTIAKAFPATTTD------------------QPIFLYSNDDNNVQLPQQ 398
            .||:|..:  |.::|||...::......:                  ..|.....|.|.:|..|:
Mouse   388 FLFDNSKINYETQITPRPQPESVSCILQEPKRNLSFFQLRKVWGQVWHSIQTLKEDCNRLQQGQR 452

  Fly   399 LDLPKFPVFPPNVSVENDASLAK---SACSVGHECKRRVDIF-TSMDILIKKGVEHFIEMLVTTI 459
            ..:...        :.|::.|:|   :..|...:.|.::|.| ||:.|.::|..|. .|..:|:
Mouse   453 AAMMSL--------LRNNSCLSKMKNAMASTAQQLKAKLDFFKTSIQIDLEKYKEQ-TEFGITS- 507

  Fly   460 TLLLKKTESFDNLLSTVIDYADVVHSMARVTKGDQEIKTLLTALENVKSDFDGAADVISQMHKHF 524
                      |.||....:....|....|    :.::|.|:..:..:::|
Mouse   508 ----------DKLLLAWREMEQAVEQCGR----ENDVKHLVERMMALQTD--------------- 543

  Fly   525 VIDDELNDQWTSSMHGKKCPCKTRASAQAKYLVERLRDSWQHLLRDRATRTLTYNDEQFHALEKI 589
                 :.|...|.|..|:.........||:.|..|||:.    .||:.|.    .|.|
Mouse   544 -----IVDLQRSPMGRKQGGTLDDLEEQARELYRRLREK----PRDQRTE----GDSQ------- 588

  Fly   590 KVDHNGKRIKALLLDNVNPTVAQIAECLADWYKLAQTVYLKTQILEKDVRDCERKLNGIRDELYH 654
                  :.::.||            :.:..:.|..:.:|  ||:.:..|  |::|...:..::..
Mouse   589 ------EMVRLLL------------QAIQSFEKKVRVIY--TQLSKTVV--CKQKALELLPKVEE 631

  Fly   655 VKSELKLDVDTKTINNNNQLAKIEERNRLRVMQQQQQEVMAVMRTNSDIISLLSKLGITNGSLES 719
            |.|                |...:||..:|:.:::|:|:..:::     |:.....|..:||.:|
Mouse   632 VVS----------------LMNEDERTVVRLQEKRQKELWNLLK-----IACSKVRGPVSGSPDS 675

Fly 720 719
Mouse 676 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IKKepsilon	NP_610048.2	Pkinase	16..297	CDD:278497	84/292 (29%)
		STKc_TBK1	18..332	CDD:270890	91/326 (28%)
		UBL_TBK1_like	299..389	CDD:240618	22/145 (15%)
Ikbkb	NP_001153246.1	S_TKc	15..290	CDD:214567	85/290 (29%)
		STKc_IKK_beta	20..309	CDD:270940	87/304 (29%)
		Leucine-zipper	458..479		4/28 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	683..703
		IKKbetaNEMObind	708..742	CDD:288990
		NEMO-binding	737..742
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4250
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770