Protein Alignment IKKepsilon and ikbke

DIOPT Version :10

• Sequence 1: NP_610048.2
• Gene: IKKepsilon / 35329
• FlyBaseID: FBgn0086657
• Length: 720
• Species: Drosophila melanogaster
• Sequence 2: XP_031752733.1
• Gene: ikbke / 100487744
• XenbaseID: XB-GENE-994611
• Length: 718
• Species: Xenopus tropicalis
• Alignment Length: 763
• Identity: 263/763 - (34%)
• Similarity: 392/763 - (51%)
• Gaps: 101/763 - (13%)

  Fly     4 LRGSVSYVWCTTSVLGKGATGSVFQGVNKITGESVAVKTFNPYSHMRPADVQMREFEALKKVNHE 68
            ::.:.:|:|....|||:|||.||::..||.:||.||||.||..|::||.:|||||||.|:|:||.
 Frog     1 MQSTPNYLWELDDVLGQGATASVYKARNKKSGEEVAVKVFNNLSYLRPLEVQMREFEMLRKLNHV 65

  Fly    69 NIVKLLAIEEDQEGRGKVIVMELCTGGSLFNILDDPENSYGLPEHEFLLVLEHLCAGMKHLRDNK 133
            |||||.|:||....:.||:|||.|:.|||.::|:||||:|||.|.|||:||:.:.|||.|||.|.
 Frog    66 NIVKLFAVEETGNSKQKVLVMEYCSSGSLLSVLEDPENAYGLSEAEFLIVLQCVVAGMNHLRQNG 130

  Fly   134 LVHRDLKPGNIMKFISEDGQTIYKLTDFGAARELEDNQPFASLYGTEEYLHPDLYERAVLRKSIQ 198
            :||||:||||||:.|.|||::|||||||||||||:|::.|.|:||||||||||:||||||:|..|
 Frog   131 IVHRDIKPGNIMRLIGEDGRSIYKLTDFGAARELDDDEKFLSIYGTEEYLHPDIYERAVLKKPQQ 195

  Fly   199 RSFTANVDLWSIGVTLYHVATGNLPFRPFGG-RKNRETMHQITTKKASGVISGTQLSENGPIEWS 262
            :::...|||||||||.||.|.|:|||.|:|| |:|:|.||:|.|:|....|:|.|..|.|||||.
 Frog   196 KAYGVTVDLWSIGVTFYHAACGSLPFIPYGGPRRNKEIMHKIITEKPPRAIAGVQRKEKGPIEWI 260

  Fly   263 TTLPPHAHLSQGLKTLVTPLLAGLLEENREKTWSFDRFFHEVTLILRKRVIHVFFTNRTSSVEVF 327
            ..||....||.|||..:..:|..:||.::||.|.||:||.|...||.:.|:|||.....:...|:
 Frog   261 YELPISCRLSVGLKVHLENILPNILEADQEKCWGFDKFFSETNNILERIVVHVFSLPHATMHMVY 325

  Fly   328 LEPDEQIDNFRERIFLQTEVPLEKQILLFNNEHLEKKVTPRTIAKAFPATTTDQP-IFLYSNDDN 391
            :.....:.||.|.:..||.|..|.|...:...|.  .:.|....|....||...| |.:.|..|.
 Frog   326 VLACSSVVNFMEAVSKQTGVAFENQKYFYEGHHY--PMMPTLQVKHITGTTEQHPFILMSSTSDC 388

  Fly   392 NVQLPQQLDLPKFPVFPPNVSVENDASLAKSACSVGHECKRRVDIFTSMDILIKKGVEHFIEMLV 456
            .|:...:.....||.|.|:|.|..|.|:||:..|..::..|......:....|.:|....||...
 Frog   389 IVKATYKDPTNDFPRFLPSVDVVADCSIAKNVLSAVYQTLRVARALLTCQEFILRGTYWLIENTK 453

  Fly   457 TTITLLLKKTESFDNLLSTVIDYADVVHSMARVTKGDQEIKTLLTALENVKSDFDGAADV----- 516
            |....:|:|..:..:||:..|...:      |:|:       |..::.|.|.:|....|:
 Frog   454 TECHQILEKKSTMASLLNCTISTEN------RITR-------LYNSVNNRKPEFPEFPDLAECRR 505

  Fly   517 ----------------------------ISQMHKHFVIDDELNDQWTSSMHGKKCPCKTRASAQA 553
                                        :|:......:|..:|                    :.
 Frog   506 QLQSIGHTLSSCSHIVEKQNMLEFLSLEVSKNQDQIQLDTSIN--------------------RM 550

  Fly   554 KYLVERLRDSWQHLLRDRATRTLTYNDEQFHALEKIKVDHNGKRIKALLLDNVNPTVAQIAECLA 618
            :|.:.:::..:....:.:....|.||:||.|.|:|:.:.:..|::.|:..|.|           .
 Frog   551 EYCLRKMQLIFNQFKKRKQQSRLGYNEEQLHKLDKVNLGNLAKKVLAIFQDGV-----------V 604

  Fly   619 DWYKLAQTVYLKTQILEKDVRDCERKLNG-----------IRDELYHVKSELKLDVDTKTINNNN 672
            ..||.|...:........|:......:||           .:|.:.:...:|.|.:...:..|::
 Frog   605 QKYKAALDKHSNRMSTFADILKHVDLVNGYFGGSFLDLQKYQDSVNNAVDDLTLRIQQMSEPNHS 669

  Fly   673 QLAKIEERN------RLRVMQQQQQEVMAVMRTNSDIISLLSKLGITN 714
            .|.....::      |:..::.|.:.|...::.|:   |::.:||:|:
 Frog   670 PLPSCHNQDKEDLTLRMLKLRDQMKTVSYELQQNN---SVIERLGVTS 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IKKepsilon	NP_610048.2	STKc_TBK1	18..332	CDD:270890	178/314 (57%)
		Ubl_TBK1_like	310..388	CDD:340518	20/78 (26%)
		TBK1_CCD1	405..656	CDD:465742	51/294 (17%)
ikbke	XP_031752733.1	Protein Kinases, catalytic domain	15..327	CDD:473864	178/311 (57%)
		Ubl1_cv_Nsp3_N-like	308..384	CDD:475130	20/77 (26%)
		TBK1_CCD1	402..651	CDD:465742	51/292 (17%)
		TBK1_IKKE-like_C	676..718	CDD:409261	8/42 (19%)