DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IKKepsilon and ikbke

DIOPT Version :9

Sequence 1:	NP_610048.2	Gene:	IKKepsilon / 35329	FlyBaseID:	FBgn0086657	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	XP_031752733.1	Gene:	ikbke / 100487744	XenbaseID:	XB-GENE-994611	Length:	718	Species:	Xenopus tropicalis

Alignment Length:	763	Identity:	263/763 - (34%)
Similarity:	392/763 - (51%)	Gaps:	101/763 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LRGSVSYVWCTTSVLGKGATGSVFQGVNKITGESVAVKTFNPYSHMRPADVQMREFEALKKVNHE 68
            ::.:.:|:|....|||:|||.||::..||.:||.||||.||..|::||.:|||||||.|:|:||.
Frog     1 MQSTPNYLWELDDVLGQGATASVYKARNKKSGEEVAVKVFNNLSYLRPLEVQMREFEMLRKLNHV 65

  Fly    69 NIVKLLAIEEDQEGRGKVIVMELCTGGSLFNILDDPENSYGLPEHEFLLVLEHLCAGMKHLRDNK 133
            |||||.|:||....:.||:|||.|:.|||.::|:||||:|||.|.|||:||:.:.|||.|||.|.
Frog    66 NIVKLFAVEETGNSKQKVLVMEYCSSGSLLSVLEDPENAYGLSEAEFLIVLQCVVAGMNHLRQNG 130

  Fly   134 LVHRDLKPGNIMKFISEDGQTIYKLTDFGAARELEDNQPFASLYGTEEYLHPDLYERAVLRKSIQ 198
            :||||:||||||:.|.|||::|||||||||||||:|::.|.|:||||||||||:||||||:|..|
Frog   131 IVHRDIKPGNIMRLIGEDGRSIYKLTDFGAARELDDDEKFLSIYGTEEYLHPDIYERAVLKKPQQ 195

  Fly   199 RSFTANVDLWSIGVTLYHVATGNLPFRPFGG-RKNRETMHQITTKKASGVISGTQLSENGPIEWS 262
            :::...|||||||||.||.|.|:|||.|:|| |:|:|.||:|.|:|....|:|.|..|.|||||.
Frog   196 KAYGVTVDLWSIGVTFYHAACGSLPFIPYGGPRRNKEIMHKIITEKPPRAIAGVQRKEKGPIEWI 260

  Fly   263 TTLPPHAHLSQGLKTLVTPLLAGLLEENREKTWSFDRFFHEVTLILRKRVIHVFFTNRTSSVEVF 327
            ..||....||.|||..:..:|..:||.::||.|.||:||.|...||.:.|:|||.....:...|:
Frog   261 YELPISCRLSVGLKVHLENILPNILEADQEKCWGFDKFFSETNNILERIVVHVFSLPHATMHMVY 325

  Fly   328 LEPDEQIDNFRERIFLQTEVPLEKQILLFNNEHLEKKVTPRTIAKAFPATTTDQP-IFLYSNDDN 391
            :.....:.||.|.:..||.|..|.|...:...|.  .:.|....|....||...| |.:.|..|.
Frog   326 VLACSSVVNFMEAVSKQTGVAFENQKYFYEGHHY--PMMPTLQVKHITGTTEQHPFILMSSTSDC 388

  Fly   392 NVQLPQQLDLPKFPVFPPNVSVENDASLAKSACSVGHECKRRVDIFTSMDILIKKGVEHFIEMLV 456
            .|:...:.....||.|.|:|.|..|.|:||:..|..::..|......:....|.:|....||...
Frog   389 IVKATYKDPTNDFPRFLPSVDVVADCSIAKNVLSAVYQTLRVARALLTCQEFILRGTYWLIENTK 453

  Fly   457 TTITLLLKKTESFDNLLSTVIDYADVVHSMARVTKGDQEIKTLLTALENVKSDFDGAADV----- 516
            |....:|:|..:..:||:..|...:      |:|:       |..::.|.|.:|....|:
Frog   454 TECHQILEKKSTMASLLNCTISTEN------RITR-------LYNSVNNRKPEFPEFPDLAECRR 505

  Fly   517 ----------------------------ISQMHKHFVIDDELNDQWTSSMHGKKCPCKTRASAQA 553
                                        :|:......:|..:|                    :.
Frog   506 QLQSIGHTLSSCSHIVEKQNMLEFLSLEVSKNQDQIQLDTSIN--------------------RM 550

  Fly   554 KYLVERLRDSWQHLLRDRATRTLTYNDEQFHALEKIKVDHNGKRIKALLLDNVNPTVAQIAECLA 618
            :|.:.:::..:....:.:....|.||:||.|.|:|:.:.:..|::.|:..|.|           .
Frog   551 EYCLRKMQLIFNQFKKRKQQSRLGYNEEQLHKLDKVNLGNLAKKVLAIFQDGV-----------V 604

  Fly   619 DWYKLAQTVYLKTQILEKDVRDCERKLNG-----------IRDELYHVKSELKLDVDTKTINNNN 672
            ..||.|...:........|:......:||           .:|.:.:...:|.|.:...:..|::
Frog   605 QKYKAALDKHSNRMSTFADILKHVDLVNGYFGGSFLDLQKYQDSVNNAVDDLTLRIQQMSEPNHS 669

  Fly   673 QLAKIEERN------RLRVMQQQQQEVMAVMRTNSDIISLLSKLGITN 714
            .|.....::      |:..::.|.:.|...::.|:   |::.:||:|:
Frog   670 PLPSCHNQDKEDLTLRMLKLRDQMKTVSYELQQNN---SVIERLGVTS 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IKKepsilon	NP_610048.2	Pkinase	16..297	CDD:278497	167/281 (59%)
		STKc_TBK1	18..332	CDD:270890	178/314 (57%)
		UBL_TBK1_like	299..389	CDD:240618	26/90 (29%)
ikbke	XP_031752733.1	PKc_like	15..327	CDD:419665	178/311 (57%)
		Ubiquitin_like_fold	308..384	CDD:421700	20/77 (26%)
		TBK1_CCD1	402..651	CDD:408193	51/292 (17%)
		TBK1_IKKE-like_C	676..718	CDD:409261	8/42 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	302	1.000	Domainoid score	I1391
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	439	1.000	Inparanoid score	I1629
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D257949at33208
OrthoFinder	1	1.000	-	-		FOG0002906
OrthoInspector	1	1.000	-	-		otm48819
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2267
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060