DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IKKepsilon and tbk1

DIOPT Version :9

Sequence 1:	NP_610048.2	Gene:	IKKepsilon / 35329	FlyBaseID:	FBgn0086657	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_001135652.1	Gene:	tbk1 / 100216212	XenbaseID:	XB-GENE-955452	Length:	725	Species:	Xenopus tropicalis

Alignment Length:	756	Identity:	275/756 - (36%)
Similarity:	432/756 - (57%)	Gaps:	82/756 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LRGSVSYVWCTTSVLGKGATGSVFQGVNKITGESVAVKTFNPYSHMRPADVQMREFEALKKVNHE 68
            ::.:.:::|..:.:||:|||.:|::|.||.||:..|||.||..|.:|||||||||||.|||:||:
Frog     1 MQSTANHLWLLSDILGQGATANVYRGRNKKTGDLYAVKVFNNLSFLRPADVQMREFEVLKKLNHK 65

  Fly    69 NIVKLLAIEEDQEGRGKVIVMELCTGGSLFNILDDPENSYGLPEHEFLLVLEHLCAGMKHLRDNK 133
            |||||.||||:...|.||:|||.|...||:::|::|.|:|||||.|||:|...:.|||.|||:|.
Frog    66 NIVKLFAIEEEMSSRHKVLVMEFCPCASLYSVLEEPANAYGLPESEFLIVSRDVVAGMNHLRENG 130

  Fly   134 LVHRDLKPGNIMKFISEDGQTIYKLTDFGAARELEDNQPFASLYGTEEYLHPDLYERAVLRKSIQ 198
            ::|||:||||||:.|.||||::||||||||||||:|::.|.||||||||||||:||||||||..|
Frog   131 IIHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELDDDEQFVSLYGTEEYLHPDMYERAVLRKEHQ 195

  Fly   199 RSFTANVDLWSIGVTLYHVATGNLPFRPF-GGRKNRETMHQITTKKASGVISGTQLSENGPIEWS 262
            :.:.|.|||||||||.||.|||:|||||| |.|:|:|.|::|...|.||.|||.|.:||||||||
Frog   196 KKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIAGKPSGAISGVQRAENGPIEWS 260

  Fly   263 TTLPPHAHLSQGLKTLVTPLLAGLLEENREKTWSFDRFFHEVTLILRKRVIHVFFTNRTSSVEVF 327
            ..||...:||.||:||.||:||.:||.::||.|.|::||.....:..:.|||||...:.:..:::
Frog   261 GELPVTCNLSMGLQTLFTPVLANILEADQEKCWGFEQFFAVTNDVFNRIVIHVFSLQQMTPHKIY 325

  Fly   328 LEPDEQIDNFRERIFLQTEVPLEKQILLFNNEHLEKKVTPRTIAKAFPATTTDQPIFLYSNDDNN 392
            :...:::.:|.:.::.||::|.:.|.|||....|  .:....:|:.||.||.:.|||:.:.:..:
Frog   326 INTYDKVPDFHDLVYKQTKIPAQNQELLFEGRRL--VLEQGRLAQHFPITTEENPIFVLTREMVS 388

  Fly   393 VQLPQQLDLPKFPVFPPNVSVENDASLAKSACSVG-HECKRRVDIFTSMDILIKKGVEHFIEMLV 456
            | :..:.|....|....:..::.||::||:...|. :.|:....:...:: |::||:....|:|.
Frog   389 V-IGLRFDEIVIPKLHSHYDLDVDANMAKAVTGVACYYCRIAASLLLVLE-LMRKGIRWLSEILK 451

  Fly   457 ----------TTITLLL--------KKTESFDNLLSTVID---YADVVHSMARVTKGDQEIKTLL 500
                      |.::|.|        |..::::.|:.|.::   |  |:|.........||  :|.
Frog   452 EEYNENVHRNTEVSLKLSFCNRTIEKDLKTYEQLIQTSVEPEVY--VIHGKLLNLSSTQE--SLK 512

  Fly   501 TALENVKSDFDGAADVISQMHKHFVIDDELNDQWTSSMHGKKCPCKTRASAQAKYLVERLRDSWQ 565
            ::|:.:|:......         .::|..:|.:.|.|        ..|...:.:.|:..:.:.:.
Frog   513 SSLQEIKNKLTPGG---------VLMDSWINAEGTHS--------ADRNVEKLQVLLSLITEIYC 560

  Fly   566 HLLRDRATRTLTYNDEQFHALEKIKVDHNGKRIKALLLDNVNPTVAQIAECLA----------DW 620
            ...:|:|.|.|.||:||.|..:|.|:..:..:..:|..|          ||:.          ||
Frog   561 QFKKDKAQRRLLYNEEQIHKFDKQKMCIHSTKAYSLFKD----------ECVGKYEGFRSKALDW 615

  Fly   621 YK-----LAQTVYLKTQI--LEKDVRDCERKLNGIRD----ELYHVKSELKLDVDTKTINNNNQL 674
            .:     ..|...||:|.  :|::|..|:..:|..::    :::.....:|..|: ...::.|.|
Frog   616 MRKMIHVRKQLFSLKSQCFEIEEEVSKCQHYINQYQEKMSPKMFAAPGGIKSAVN-PIYSSPNTL 679

  Fly   675 AKIEERNRLRVMQQQQQEVMAVMRTNSDIISLLSKLGITNG 715
              :|....:|.:::..:.|:..:..|:.|:.....|.|..|
Frog   680 --VEMTLGMRKLKEDMEGVVKELEENNHILERFGALTIDGG 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IKKepsilon	NP_610048.2	Pkinase	16..297	CDD:278497	178/281 (63%)
		STKc_TBK1	18..332	CDD:270890	186/314 (59%)
		UBL_TBK1_like	299..389	CDD:240618	24/89 (27%)
tbk1	NP_001135652.1	STKc_TBK1	15..330	CDD:270890	186/314 (59%)
		Ubl_TBK1	308..385	CDD:340647	22/78 (28%)
		TBK1_CCD1	400..651	CDD:408193	57/282 (20%)
		TBK1_C	674..720	CDD:409263	10/47 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	302	1.000	Domainoid score	I1391
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22742
Inparanoid	1	1.050	439	1.000	Inparanoid score	I1629
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D257949at33208
OrthoFinder	1	1.000	-	-		FOG0002906
OrthoInspector	1	1.000	-	-		otm48819
Panther	1	1.100	-	-	O	PTHR22969
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2267
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.070