DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31678 and suco-1

DIOPT Version :9

Sequence 1:	NP_724277.2	Gene:	CG31678 / 35327	FlyBaseID:	FBgn0051678	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_001370471.1	Gene:	suco-1 / 172011	WormBaseID:	WBGene00020031	Length:	802	Species:	Caenorhabditis elegans

Alignment Length:	946	Identity:	198/946 - (20%)
Similarity:	356/946 - (37%)	Gaps:	299/946 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   321 SAAFNGTEGTANLT-NANEEVPMPV-----FSEWAQKQMEAEASREQAMELEQQVVNKSAQRKNN 379
            ||.:|.::.....: ||:|:..:|.     |.||.:|:.:|.|::..    :.|...:..|...:
Worm    54 SAPYNVSKKIMKASVNASEKDSIPEKSIDNFDEWTKKRRDAVANQNG----QNQKTIEPTQVARH 114

  Fly   380 TGSSSGKPPTLKLRSKNYASPDCGAKIIAHNSESKHTEAVLTQ-STDEYMLSTCES--RIWFVVE 441
            ...|...||..: ..:|:||.:|||||||.|.|:::.:||:.: ..|:||.:.|:|  ..:.|:|
Worm   115 DEVSIPLPPITR-PPRNFASRECGAKIIAANPEAENAKAVVNEKDVDDYMRNPCQSAKEKFIVIE 178

  Fly   442 LCEAIQAQKVDVANYELFSSSPKNFTVAVSKRF-PTRDWSNVGRFAAED-KRTIQTFEL-HPHLF 503
            ||||||.:|:.:.|:|||:|.||...|.:|:|: |..:|.:||.|..:| .:.:|||:: :.:::
Worm   179 LCEAIQIKKIAIGNFELFASRPKTIQVFISERYPPLANWISVGPFHLQDHHKNLQTFDVPNTNVY 243

  Fly   504 GKFVRVDITSHYANEHFCPLSLFRVFGTSEYEAFETEIRPSDDLDDFYDDYGAQEQKAAVGSGGN 568
            .|:||:::..||..||:|.:|:..|.|::              |.|.||    :|:.||
Worm   244 AKYVRINLEDHYGKEHYCIVSVVNVMGST--------------LADEYD----KEEAAA------ 284

  Fly   569 IFQSASDAVMQMVKKAAEVLVKPTKALKWSEESVLCQTPAFEAFSCINCNTTLVERINSLLSCQF 633
                      .::....||..:|......||:.:..|.|....    :.|.|:..|:.|:   .|
Worm   285 ----------HLLNVIEEVKEEPVTTPPPSEQKMQTQLPVPPK----SPNQTVSARMKSV---DF 332

  Fly   634 QQLQALLSLSHLRSDLLNSRVCQEEFGISLTGSEFASKMGKEQSYFLSMLPAEHVGAMCKLIQAE 698
            :||::               ||.:            ..:||..:....:||      :...::..
Worm   333 RQLKS---------------VCSQ------------CSVGKVSNLICHILP------IPTRVKKN 364

  Fly   699 QNVTDHNHTKAPSLKQHVSSPEPVQDNATATGVRQDCENSKTPTKEPLTPSLEVVVPEVSQEVPS 763
            ..|...|:.|..::|..|:....::........|....|.:...:..|. :::.:.|:..|::.:
Worm   365 DLVKPPNNLKTSTIKPAVTDKRDLKTEIGLWAERSRHSNFEQSRRRNLA-TIQRLHPKDVQKIST 428

  Fly   764 MEDQSSTSSETVSTTNSTPADVNIFNMPSEPEEVVVKVQLPPEPTLPTTLQPSDVESFTDAPSTN 828
            ..|..:..:|.:......|::     ....|.....:|.|||:|
Worm   429 APDVPTPKAENIEKPTEKPSE-----EVKPPAREQPQVSLPPKP--------------------- 467

  Fly   829 ALPGSSEAVANGDLGMEEGNPANWDGIDNLLTTTVASITAGGGAAAAAAAVVNGNANIGGAGIVG 893
                .||.:                            :.|||.
Worm   468 ----KSEPI----------------------------LPAGGS---------------------- 478

  Fly   894 AGGPASLSSVNMQQKLTNGAQSESVFIRLSNRIKALERNMSLSGQYLEELSRRYKKQVEELQQTL 958
                            ||  |.|.|.::||.||.|:|.|::||.:||.|||::|..|:...||.|
Worm   479 ----------------TN--QRELVLMKLSKRIAAVELNLTLSSEYLSELSKQYVSQMSGYQQEL 525

  Fly   959 ---------TQQTLTV----------RQLED-----------QSRRY--VEQE------------ 979
                     |.||:..          |:|.|           ::.||  |:.|
Worm   526 KETRKASKKTAQTVEAMMRSKMNGVKRELRDLRQSVYLLQKLENSRYNNVQSEMSRQVLMSSCHI 590

  Fly   980 -----------------------------------QLYQQHSAELAGEVRALSYQVQACILVIII 1009
                                               ::|:...:.:.|   :|::.....|:.:|.
Worm   591 SSNVPPSPTIARLPLIIPALNRKLENFTNFEERMKKIYETAKSVMFG---SLTWNTDHLIVALIS 652

  Fly  1010 VGTCIFLMLVLGTVYY---RKLRRQQQQLLKKDQAGHPPVAAKPKLDRRKSYEQTPNQSTPKQRR 1071
            ........|..|..|.   .|.|.::.|::.|::.  ....||..::.||...:...::......
Worm   653 FNIMALSFLFAGVFYIHRRNKERCEETQIIVKNEL--RARIAKVGIENRKLISKGMRRAELAVTA 715

  Fly  1072 PSEEAMLILKECGD-SNMQELDP------PSRQRKISVCYGSNNNIAANMAIANTNGGASVRNSL 1129
            ....|:.|.|...: |.|.||:.      .::|.:|...:..|..:              :|::|
Worm   716 AVSSALKIEKTSSNRSAMTELETALANLFEAQQTRIEEQFEQNQKM--------------LRDAL 766

  Fly  1130 HRRKGAKHSWHNSLDTTETSCGEQTDKFFDVDTLKS 1165
            ..|.|::.....|::.:|:|...:..| .|..||.:
Worm   767 SERNGSRFDDTLSVEDSESSSETEHSK-EDTPTLNA 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31678	NP_724277.2	Sad1_UNC	409..532	CDD:285038	48/128 (38%)
suco-1	NP_001370471.1	Sad1_UNC	144..272	CDD:400199	48/127 (38%)
suco-1	NP_001370471.1	PRK11633	<424..>471	CDD:236940	11/76 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158676
Domainoid	1	1.000	94	1.000	Domainoid score	I4733
eggNOG	1	0.900	-	-		E1_KOG1396
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003583
OrthoInspector	1	1.000	-	-		oto20285
orthoMCL	1	0.900	-	-		OOG6_103990
Panther	1	1.100	-	-	LDO	PTHR12953
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1347
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.860