DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2614 and mettl13

DIOPT Version :9

Sequence 1:	NP_610045.1	Gene:	CG2614 / 35326	FlyBaseID:	FBgn0032873	Length:	673	Species:	Drosophila melanogaster
Sequence 2:	NP_001107964.1	Gene:	mettl13 / 733963	XenbaseID:	XB-GENE-965488	Length:	693	Species:	Xenopus tropicalis

Alignment Length:	717	Identity:	282/717 - (39%)
Similarity:	410/717 - (57%)	Gaps:	69/717 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNLLPKTREEFAQTDYWNEFFKKRGEKAFEWYGEYLELCDQIHKYIKPADRILMLGCGNSKLSMD 65
            |:||||:.:|||..:||.:||::|||:||||||.|||||..:||||||.|::|::|||||:||..
Frog     1 MDLLPKSSKEFAAPEYWEQFFRRRGERAFEWYGGYLELCGLLHKYIKPRDKVLVVGCGNSELSER 65

  Fly    66 MYDTGFRDITNIDISPIAVKKMLELNAKSRPEMKFLQMDATAMTFPDESFSVSLDKGTLDALFAD 130
            :||.|.:::||||:|.:.:::|.|.|:..||.|.|..||||..||.|..|...||||||||:..|
Frog    66 LYDAGCQNLTNIDVSEVVIRQMKERNSSRRPNMTFQVMDATQTTFDDSYFQTVLDKGTLDAIMTD 130

  Fly   131 DEPETRAVVENYFKEILRTMRNGGRYVGISLLQEHILNFLLDFLPKHNCMLRIVHCLGVEQANKE 195
            .:..|....:....||.|.:..|||::.:||.|.|:|..|:....:...|:|:...:    ....
Frog   131 TDERTLETADKMMSEIGRLLTCGGRFLCVSLAQAHVLEKLVGHFSQGGFMIRVHQVM----QGST 191

  Fly   196 KNADDALTLPVFVVVATKFKSLP--------MPVLEFGFGNDKMQRFTTVSELNSAVSSVQKAAL 252
            ..:|....:||||.|.||.:.:.        ||..|.|    |..|:.:..||..||...|:.||
Frog   192 SESDSQFPMPVFVFVMTKVRQISGFPTVLEMMPDEEGG----KPARWASPEELMEAVKERQRYAL 252

  Fly   253 VCNGLARSNIAGHNEVIMDLHRPSEQTPRYTIHILDKPPAR--GLGKYAAFIVPQGREVEWIFST 315
            :.|.|.::.  ...|:.:||.....:..|||.:|:|.|..|  ....:|.||:|||||.||:|.:
Frog   253 IRNRLNQNQ--SSQEISLDLCDGDSRKSRYTFYIVDNPTVRLSHSNHFAIFIIPQGRETEWLFGS 315

  Fly   316 PAGRKKLQDSANFQRLAVVTLHRDQVYSTLDEVKQELADSIKNLSPAGLTD--QIPYLSLGSDVG 378
            ..||::|..|..|:||.:|.|||||.|:.:..::.||:..:..|:|.||.|  |||:||.|.|:|
Frog   316 EQGRRQLSGSVGFRRLIIVALHRDQQYTDMKAIQSELSAKVLELAPPGLPDHQQIPFLSAGEDIG 380

  Fly   379 KRETLICGFSKISGDFRIEEVEANG-KTLRRLIFLSNQFVVQSEALVKTVKI----KGKKDRKK- 437
            .|.....|.|..||::.:|:|:.:| .:.|||||||||.||||||.:..:..    |.:||:||
Frog   381 ARTIQHRGKSDFSGEYVVEDVKGDGNSSYRRLIFLSNQNVVQSEARLLPINTHIGQKKRKDKKKH 445

  Fly   438 --------------IDFGYLACQHHLYMSVGVQLATTVQHPKRDV----EKDVLVVGLGGGGLCS 484
                          ||..||.|:||..|..|:.:.     |...:    :..||::|||||.|..
Frog   446 QKPVKDLEQPTVTRIDKSYLCCEHHKAMISGLAML-----PNSGILPECKTSVLLIGLGGGSLSL 505

  Fly   485 FLHAALPQARITAVEIDPIMLEVAEQYFELKQDKRFHVVIDDGL-------DFVERCRNEDIHFD 542
            |:|...|.:|:..|||||.:|:||..:|...||.|..|.:.|||       |..|.|      :|
Frog   506 FIHDYFPGSRVEVVEIDPSVLDVACNWFSFCQDDRMKVQLADGLVHINSLADSGEAC------YD 564

  Fly   543 AVLFDVDSKDLSLGMSCPPQSFLATKILQHIKEIIGPKGLFMLNLVCRDESLRTEALNNLHKVFP 607
            .::|||||||.|:||||||.:|:....||::.:|:.|.|:|:|||||||..||.:.||.|.::||
Frog   565 VIMFDVDSKDPSVGMSCPPPAFVEKIFLQNVHKILNPNGVFILNLVCRDAVLRLKVLNVLREIFP 629

  Fly   608 AVCSYKLEEDINEIIY-CANDEKYKTVEQWKKNMGTAGRGLNSAVKETKLASEDALEVAEFLSEL 671
            .:.:.|::|::|||:: |||.|:..:..:.|:    ....|...:|:..:..:....:||.|..:
Frog   630 LIYAQKIDEEVNEILFCCANSERKLSSLELKE----LAMNLEKKLKKPGVQWDSTYSLAEMLKSV 690

  Fly   672 KI 673
            :|
Frog   691 QI 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2614	NP_610045.1	AdoMet_MTases	55..157	CDD:302624	46/101 (46%)
CG2614	NP_610045.1	AdoMet_MTases	<483..>612	CDD:302624	59/135 (44%)
mettl13	NP_001107964.1	Methyltransf_25	52..154	CDD:379312	44/101 (44%)
mettl13	NP_001107964.1	AdoMet_MTases	<506..>629	CDD:388410	57/128 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	176	1.000	Domainoid score	I3562
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H32285
Inparanoid	1	1.050	438	1.000	Inparanoid score	I1634
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D373793at33208
OrthoFinder	1	1.000	-	-		FOG0006581
OrthoInspector	1	1.000	-	-		oto103666
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4655
SonicParanoid	1	1.000	-	-		X5580
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090