DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2614 and METTL13

DIOPT Version :9

Sequence 1:	NP_610045.1	Gene:	CG2614 / 35326	FlyBaseID:	FBgn0032873	Length:	673	Species:	Drosophila melanogaster
Sequence 2:	NP_057019.3	Gene:	METTL13 / 51603	HGNCID:	24248	Length:	699	Species:	Homo sapiens

Alignment Length:	726	Identity:	306/726 - (42%)
Similarity:	421/726 - (57%)	Gaps:	81/726 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNLLPKTREEFAQTDYWNEFFKKRGEKAFEWYGEYLELCDQIHKYIKPADRILMLGCGNSKLSMD 65
            ||||||:..||...|||.:||::||:|||||||.|||||..:||||||.:::|::|||||:||..
Human     1 MNLLPKSSREFGSVDYWEKFFQQRGKKAFEWYGTYLELCGVLHKYIKPREKVLVIGCGNSELSEQ 65

  Fly    66 MYDTGFRDITNIDISPIAVKKMLELNAKSRPEMKFLQMDATAMTFPDESFSVSLDKGTLDALFAD 130
            :||.|:|||.|||||.:.:|:|.|.||..||:|.||:||.|.|.|||.||.|.||||||||:..|
Human    66 LYDVGYRDIVNIDISEVVIKQMKECNATRRPQMSFLKMDMTQMEFPDASFQVVLDKGTLDAVLTD 130

  Fly   131 DEPETRAVVENYFKEILRTMRNGGRYVGISLLQEHILNFLLDFLPKHNCMLRIVHCLGVEQANKE 195
            :|.:|...|:....|:.|.::.||||:.|||.|.|||...:....:...|:| ||    :.||.:
Human   131 EEEKTLQQVDRMLAEVGRVLQVGGRYLCISLAQAHILKKAVGHFSREGWMVR-VH----QVANSQ 190

  Fly   196 K---NADDALTLPVFVVVATKFKSLPMPVLEF----GFGNDKMQRFTTVSELNSAVSSVQKAALV 253
            .   .|:...:||||..:.|||:.:|...|:.    .....|..|..:...|..||...|:.|.:
Human   191 DQVLEAEPQFSLPVFAFIMTKFRPVPGSALQIFELCAQEQRKPVRLESAERLAEAVQERQQYAWL 255

  Fly   254 CNGLARSNIAGHNEVIMDLHRPSEQTPRYTIHILDKP---PARGLGKYAAFIVPQGREVEWIFST 315
            |:.|.|....|  .|.:||.......||||:|::|.|   |:|. ..:|.||:|||||.||:|..
Human   256 CSQLRRKARLG--SVSLDLCDGDTGEPRYTLHVVDSPTVKPSRD-NHFAIFIIPQGRETEWLFGM 317

  Fly   316 PAGRKKLQDSANFQRLAVVTLHRDQVYSTLDEVKQELADSIKNLSPAGL--TDQIPYLSLGSDVG 378
            ..|||:|..||.|:||..|.|||.|.|.::|.::.||:..:..|:|||:  ..|:|:||:|.|:|
Human   318 DEGRKQLAASAGFRRLITVALHRGQQYESMDHIQAELSARVMELAPAGMPTQQQVPFLSVGGDIG 382

  Fly   379 KRETLICGFSKISGDFRIEEVEANGKT-LRRLIFLSNQFVVQSEA-LVKTVKIKG----KKDRKK 437
            .|.......|.:|||:.||:|:.:.|. .||||||||:.|||||| |:|.|..|.    ||||||
Human   383 VRTVQHQDCSPLSGDYVIEDVQGDDKRYFRRLIFLSNRNVVQSEARLLKDVSHKAQKKRKKDRKK 447

  Fly   438 ----------------IDFGYLACQHHLYMSVGVQLATTVQHPK--RDVEKDVLVVGLGGGGLCS 484
                            ||..||.|:||..|..|:.|   :::|:  .::...:||||||||.|..
Human   448 QRPADAEDLPAAPGQSIDKSYLCCEHHKAMIAGLAL---LRNPELLLEIPLALLVVGLGGGSLPL 509

  Fly   485 FLHAALPQARITAVEIDPIMLEVAEQYFELKQDKRFHVVIDDGLDFV---------ERCRNEDIH 540
            |:|...|::.|.||||||.|||||.|:|...|..|..|.|.||||::         ..|
Human   510 FVHDHFPKSCIDAVEIDPSMLEVATQWFGFSQSDRMKVHIADGLDYIASLAGGGEARPC------ 568

  Fly   541 FDAVLFDVDSKDLSLGMSCPPQSFLATKILQHIKEIIGPKGLFMLNLVCRDESLRTEALNNLHKV 605
            :|.::|||||||.:|||||||.:|:....||.:|.|:.|:|:|:|||||||..|:...|..|..|
Human   569 YDVIMFDVDSKDPTLGMSCPPPAFVEQSFLQKVKSILTPEGVFILNLVCRDLGLKDSVLAGLKAV 633

  Fly   606 FPAVCSYKLEEDINEIIYC--------ANDEKYKTVEQWKKNMGTAGRGLNSAVKETKLASEDAL 662
            ||.:...::|.::|||::|        |..|..:|.:..::.:...|||.           :|..
Human   634 FPLLYVRRIEGEVNEILFCQLHPEQKLATPELLETAQALERTLRKPGRGW-----------DDTY 687

  Fly   663 EVAEFLSELKI 673
            .:::.|..:||
Human   688 VLSDMLKTVKI 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2614	NP_610045.1	AdoMet_MTases	55..157	CDD:302624	55/101 (54%)
CG2614	NP_610045.1	AdoMet_MTases	<483..>612	CDD:302624	62/137 (45%)
METTL13	NP_057019.3	Methyltransf_11	53..158	CDD:285453	57/104 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	433..459		8/25 (32%)
		AdoMet_MTases	<499..673	CDD:302624	78/179 (44%)
		SmtA	<500..>650	CDD:223574	72/155 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160231
Domainoid	1	1.000	180	1.000	Domainoid score	I3522
eggNOG	1	0.900	-	-		E1_KOG2352
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32285
Inparanoid	1	1.050	515	1.000	Inparanoid score	I1304
Isobase	1	0.950	-	0	Normalized mean entropy	S4749
OMA	1	1.010	-	-		QHG57818
OrthoDB	1	1.010	-	-		D373793at33208
OrthoFinder	1	1.000	-	-		FOG0006581
OrthoInspector	1	1.000	-	-		oto89858
orthoMCL	1	0.900	-	-		OOG6_100611
Panther	1	1.100	-	-	LDO	PTHR12176
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4655
SonicParanoid	1	1.000	-	-		X5580
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750