Protein Alignment brun and TRAPPC9

DIOPT Version :9

• Sequence 1: NP_610044.2
• Gene: brun / 35325
• FlyBaseID: FBgn0261787
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: XP_011515628.1
• Gene: TRAPPC9 / 83696
• HGNCID: 30832
• Length: 1237
• Species: Homo sapiens
• Alignment Length: 1294
• Identity: 424/1294 - (32%)
• Similarity: 647/1294 - (50%)
• Gaps: 180/1294 - (13%)

  Fly    20 LSRPDYEQSALHHSCLLVLLRGVGPSRARVLQRAFEKVRRVNHIRVNDSSGHPRSIWIRFVHDHP 84
            :|.|||.|.|..|..|||:::.||........|.::::..|:.|.|.||.   |.::||:.|.:|
Human    99 MSVPDYMQCAEDHQTLLVVVQPVGIVSEENFFRIYKRICSVSQISVRDSQ---RVLYIRYRHHYP 160

  Fly    85 VEHNDWGDFQTHRRLLGLVTIGKFDSQIELNELCRQHESLKVRYGSTLYESRAIFFGPDEQPLET 149
            .|:|:||||||||:::||:||....|..:..:...:....|..||||||:||...||..
Human   161 PENNEWGDFQTHRKVVGLITITDCFSAKDWPQTFEKFHVQKEIYGSTLYDSRLFVFGLQ------ 219

  Fly   150 IGEVLGPPAAGGRRLQDEFTTPSNFKAQAFFYREQDSCADLESRIGDFASALFWVLESRRLERSR 214
             ||::..|                 :....||...:.|..:|.||.||..:||.||||:||:|:.
Human   220 -GEIVEQP-----------------RTDVAFYPNYEDCQTVEKRIEDFIESLFIVLESKRLDRAT 266

  Fly   215 EKA-DKVSLLLAPFEKRDFVGLDMESRNNRKRCVGRVMKNLADLSLQAGLVDDALSLYHNANETL 278
            :|: ||:.||..||||:||||||.:||:.:|||.||:.|::.||.||||::.|:|..||.:.|.|
Human   267 DKSGDKIPLLCVPFEKKDFVGLDTDSRHYKKRCQGRMRKHVGDLCLQAGMLQDSLVHYHMSVELL 331

  Fly   279 RSVGDSLWVGATEEGLCAASAMLLYPQMRETETLHRNSSLQEAGTSPLKNTPEKWRASDATKKIS 343
            |||.|.||:||..||||:||.:..||                .||.          .....::..
Human   332 RSVNDFLWLGAALEGLCSASVIYHYP----------------GGTG----------GKSGARRFQ 370

  Fly   344 ASDATANNVDSNQPQQRVTSNSSSCSSVSSLVTTATNSSASDTPTTSSSSTSTISAAPIPGHQRN 408
            .|...|...:.::|              .:|.|...|      |.||:.    |..|.
Human   371 GSTLPAEAANRHRP--------------GALTTNGIN------PDTSTE----IGRAK------- 404

  Fly   409 GDLPGNILKAEEISNYYRKAIINYSKYRHAATIETEAALKASRICIEQNRPLDVAMFLQNILYIN 473
                 |.|..|:|.:.|::||..||||::|..||.||.:||.|:...|.|.::.:.||||.:|||
Human   405 -----NCLSPEDIIDKYKEAISYYSKYKNAGVIELEACIKAVRVLAIQKRSMEASEFLQNAVYIN 464

  Fly   474 L-SMSEAERVKRFEVITDLYQQIGYQRKAAFFQRLAALKHVQQGSQAPDWNQSYRLMLGSFTGYR 537
            | .:||.|:::|:.::::||:.||:.||:|||:|:||::.|......|.|...|:|:|.:..||.
Human   465 LRQLSEEEKIQRYSILSELYELIGFHRKSAFFKRVAAMQCVAPSIAEPGWRACYKLLLETLPGYS 529

  Fly   538 LCLDPLEVIENA-AGWPALQIDLVQTLITAARRLGHSALATRHMTFLLQTQWDNMSPTEQSEMAV 601
            |.|||.:..... .||.|:|:.|:..|:.|:||:|:.||:.||::|||||..|.:|..|:.::|.
Human   530 LSLDPKDFSRGTHRGWAAVQMRLLHELVYASRRMGNPALSVRHLSFLLQTMLDFLSDQEKKDVAQ 594

  Fly   602 QLQNLSAQCEGSPVPLVLENGTVIPPANLTDLPYCIDLQVKDLPAHLRPQRIKVAKADS----GP 662
            .|:|.:::|.|:..|:.|..|..:||...|.||....:::.:|||.|||.::|.....:    .|
Human   595 SLENYTSKCPGTMEPIALPGGLTLPPVPFTKLPIVRHVKLLNLPASLRPHKMKSLLGQNVSTKSP 659

  Fly   663 FLFTPI--HFNSVDRRDKKKDKNKIAFQWVQNDLSEVTVRLRNPLPFELPVTDMRLLTNGVVFES 725
            |:::||  | |..:.|:||.|     |||||.|:.||.:.:.||:||||.|.:|.|||:||.|||
Human   660 FIYSPIIAH-NRGEERNKKID-----FQWVQGDVCEVQLMVYNPMPFELRVENMGLLTSGVEFES 718

  Fly   726 LPQTLVLQPHVPTY-VALHGTPIETGQLDLQGYSTHTLGVKSNCRLKHMRGRSFPPNYVVDVIPA 789
            ||..|.|......| |.|.|.|..||.:.:.||.|...||.|:|.|.::.|.. .....|:||||
Human   719 LPAALSLPAESGLYPVTLVGVPQTTGTITVNGYHTTVFGVFSDCLLDNLPGIK-TSGSTVEVIPA 782

  Fly   790 LPRISVKTSLPQTATFSNMNSADIVVTSASLTLYNGESSSCTITITNESATLPLEHLEFSINSNV 854
            |||:.:.||||::|.....:|.|.:.|:.|:.||||||....|.:.|.... |||.||  :.|.|
Human   783 LPRLQISTSLPRSAHSLQPSSGDEISTNVSVQLYNGESQQLIIKLENIGME-PLEKLE--VTSKV 844

  Fly   855 ---EQELQQKIFRIDEEAIKAHLPVPPQGTIEIIVDVFAEADFVCPQPPASLHSAAAPGDYGASS 916
               :::|.........|...|..|:.|.......:::..:.||.|.:  ..|...:..|
Human   845 LTTKEKLYGDFLSWKLEETLAQFPLQPGKVATFTINIKVKLDFSCQE--NLLQDLSDDG------ 901

  Fly   917 LTHYSSVSTSGHASLPSRVGSPHHRRNEPQNSSFRSTISGGPPSLAALTLHPGGGGGVGPSSLGS 981
                  :|.||.                |.:|.||..:.   |.:....::|......|..|
Human   902 ------ISVSGF----------------PLSSPFRQVVR---PRVEGKPVNPPESNKAGDYS--- 938

  Fly   982 QYNQHIEAQVRFKYSGGDALTAGYCRQCAVSFNLELLPSVQITSWDVLPAEVASQFYLVLDISNL 1046
             :.:.:||.:.||||||...|.||.|..::..::|:.|||..|....|||....|.:|:||:.|.
Human   939 -HVKTLEAVLNFKYSGGPGHTEGYYRNLSLGLHVEVEPSVFFTRVSTLPATSTRQCHLLLDVFNS 1002

  Fly  1047 TAQEMSLNYTDTKNILIEAKESCRVPIPVDRCSLEKVVAA--RAAEVA--ENLERELCFRTQLLS 1107
            |..|::::...::.:::.|.|..|:.|.||:.:.|....:  ...:.|  :.||.|
Human  1003 TEHELTVSTRSSEALILHAGECQRMAIQVDKFNFESFPESPGEKGQFANPKQLEEE--------- 1058

  Fly  1108 FNDALSKLCSIHIAERVKIKWLLTGTDIQGIASLRGIVLSQSMVDLTAVSPLEWAISFQDTLV-- 1170
                ..:...:.|..::.|.|.:......|.||:.|: |:|.:::...::||:|     |.||
Human  1059 ----RREARGLEIHSKLGICWRIPSLKRSGEASVEGL-LNQLVLEHLQLAPLQW-----DVLVDG 1113

  Fly  1171 QP-HNEIV--CTVGQRSLLSIQLANQSLQPLRNLVLSIKFYQDYLNGMENYNLETRVAISGPNRI 1232
            || ..|.|  |.||....|.::|.|:|.:.:....|::..:||:.||:.||:|...|:..|.:..
Human  1114 QPCDREAVAACQVGDPVRLEVRLTNRSPRSVGPFALTVVPFQDHQNGVHNYDLHDTVSFVGSSTF 1178

  Fly  1233 AIPLLEKQEQKEHTCSVIFFTPGRFKASIECTSNPQKQSEQPSSLLTRS---CPAEAES 1288
            .:..::...|.....:::|...|.|...|....:...:...||.....|   |..||::
Human  1179 YLDAVQPSGQSACLGALLFLYTGDFFLHIRFHEDSTSKELPPSWFCLPSVHVCALEAQA 1237

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brun	NP_610044.2	TRAPPC9-Trs120	42..1238	CDD:285790	403/1217 (33%)
TRAPPC9	XP_011515628.1	TRAPPC9-Trs120	112..1189	CDD:285790	406/1231 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148527
Domainoid	1	1.000	127	1.000	Domainoid score	I5393
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H81931
Inparanoid	1	1.050	593	1.000	Inparanoid score	I981
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46678
OrthoDB	1	1.010	-	-		D36257at33208
OrthoFinder	1	1.000	-	-		FOG0004159
OrthoInspector	1	1.000	-	-		oto88466
orthoMCL	1	0.900	-	-		OOG6_105002
Panther	1	1.100	-	-	LDO	PTHR21512
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4122
SonicParanoid	1	1.000	-	-		X6103
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.940