DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2608 and SPAG7

DIOPT Version :9

Sequence 1:	NP_610042.1	Gene:	CG2608 / 35323	FlyBaseID:	FBgn0032870	Length:	255	Species:	Drosophila melanogaster
Sequence 2:	NP_004881.2	Gene:	SPAG7 / 9552	HGNCID:	11216	Length:	227	Species:	Homo sapiens

Alignment Length:	238	Identity:	87/238 - (36%)
Similarity:	150/238 - (63%)	Gaps:	20/238 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DLLDSILNAMDAPPANNEQQ-KTLIKKQREMLERMQNKQKEELLRFRKYVDERMGRFAKDDRRC- 64
            |||.|||::|:.||:..:|: :...::|...|:::|.::|::.:.|||.:::.:..|.:|..:.
Human     3 DLLGSILSSMEKPPSLGDQETRRKAREQAARLKKLQEQEKQQKVEFRKRMEKEVSDFIQDSGQIK 67

  Fly    65 IEFQPLDKVHRSVIHEVAENGGFIAMSFGREDVDRHSVVYKKEHAPGEDEVTARRNGDGWNEEIA 129
            .:|||::|:.||::|:|.|..|..:.|||.:|..|:.:::|||.||.::|:.:.|.|:.|:.:.|
Human    68 KKFQPMNKIERSILHDVVEVAGLTSFSFGEDDDCRYVMIFKKEFAPSDEELDSYRRGEEWDPQKA 132

  Fly   130 KEYAERRRERLAQEQSDKEASTSEAASSGSSTSTSADQDSGEVKPTTNYKAKYAHLIGESAALQA 194
            :|  :|:.:.|||.|.:      |||..|...          |.|.::||.||:||||:.||..|
Human   133 EE--KRKLKELAQRQEE------EAAQQGPVV----------VSPASDYKDKYSHLIGKGAAKDA 179

  Fly   195 ARKTETNQSYGFVPSKNKKDVRSIEQTLADIQAKKRLRLAQQQ 237
            |...:.|::||.||..||:|.||||:.:.:|:||||||.:.::
Human   180 AHMLQANKTYGCVPVANKRDTRSIEEAMNEIRAKKRLRQSGEE 222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2608	NP_610042.1	R3H_sperm-antigen	47..106	CDD:100065	19/59 (32%)
SPAG7	NP_004881.2	DUF106	<1..>76	CDD:418652	22/72 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46		14/42 (33%)
		Nuclear localization signal. /evidence=ECO:0000255	35..51		4/15 (27%)
		R3H_sperm-antigen	49..109	CDD:100065	19/59 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	118..160		15/59 (25%)
		Nuclear localization signal. /evidence=ECO:0000255	122..139		6/18 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143139
Domainoid	1	1.000	92	1.000	Domainoid score	I7624
eggNOG	1	0.900	-	-		E1_28PDV
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3595
Inparanoid	1	1.050	162	1.000	Inparanoid score	I4223
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49694
OrthoDB	1	1.010	-	-		D1416114at2759
OrthoFinder	1	1.000	-	-		FOG0008421
OrthoInspector	1	1.000	-	-		oto91649
orthoMCL	1	0.900	-	-		OOG6_108973
Panther	1	1.100	-	-	LDO	PTHR13498
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5463
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800