DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment phr6-4 and cry3b

DIOPT Version :9

Sequence 1:	NP_001260632.1	Gene:	phr6-4 / 35322	FlyBaseID:	FBgn0016054	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_009294043.2	Gene:	cry3b / 83780	ZFINID:	ZDB-GENE-010426-5	Length:	640	Species:	Danio rerio

Alignment Length:	569	Identity:	258/569 - (45%)
Similarity:	340/569 - (59%)	Gaps:	55/569 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VHWFRKGLRLHDNPALSHIFTAANAAPGKYFVRPIFILDPGILDWMQVGANRWRFLQQTLEDLDN 73
            ||||||||||||||||......|:.      :|.::.|||.......:|.||||||.|:|||||.
Zfish     6 VHWFRKGLRLHDNPALLEALNGADT------LRCVYFLDPWFAGASNLGVNRWRFLLQSLEDLDA 64

  Fly    74 QLRKLNSRLFVVRGKPAEVFPRIFKSWRVEMLTFETDIEPYSVTRDAAVQKLAKAEGVRVETHCS 138
            .||||||.|||:||:||::|||:||.|:|..||||.|.||:...||||::|||...||.|....|
Zfish    65 SLRKLNSCLFVIRGQPADIFPRLFKEWKVSRLTFEFDSEPFGKERDAAIKKLACEAGVEVIVKIS 129

  Fly   139 HTIYNPELVIAKNLGKAPITYQKFLGIVEQLKVP-KVLGVPEK--LKNMPTPPKDEVEQKDSAAY 200
            ||:|:.:.:|..|.|::|:||::|..:|..::.| ..|..|::  :....||..:....|    |
Zfish   130 HTLYDLDRIIELNGGQSPLTYKRFQTLVSSMEPPDSPLASPDRGMMGKCVTPISENHRDK----Y 190

  Fly   201 DCPTMKQLVKRPEELGPNKFPGGETEALRRMEESLKDE---IWVARFEKPNTAPNSLEPSTTVLS 262
            ..|.:::|....|.|.|..:||||:|||:|||..|..:   .|...||:|....:.|..|...||
Zfish   191 GVPLLEELGFDTEGLAPVVWPGGESEALKRMERHLGPDSTVAWQENFERPKMNASPLMASPLGLS 255

  Fly   263 PYLKFGCLSARLFNQKLKEIIKRQPKHSQPPVSLIGQLMWREFYYTVAAAEPNFDRMLGNVYCMQ 327
            |||:|||||.|||..||.::.|:..|:..|.:||..:::||||:||.|...|.||||.||..|::
Zfish   256 PYLRFGCLSCRLFYCKLTQLYKKVKKNMNPSISLYDKILWREFFYTAATNNPRFDRMEGNPICIR 320

  Fly   328 IPWQEHPDHLEAWTHGRTGYPFIDAIMRQLRQEGWIHHLARHAVACFLTRGDLWISWEEGQRVFE 392
            |||..:.:.|..|...:||:|:|||||.||||||||||||||||||||||||||||||||.:|||
Zfish   321 IPWDRNAEALAKWAEAKTGFPWIDAIMMQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMKVFE 385

  Fly   393 QLLLDQDWALNAGNWMWLSASAFFHQYFRVYSPVAFGKKTDPQGHYIRKYVPELSKYPAGCIYEP 457
            :||||.||::|||:|:..|.|:||.|:|..|.||.||::.||.|.:||:|:|.|..:||..||:|
Zfish   386 ELLLDADWSVNAGSWLCHSCSSFFQQFFHCYCPVGFGRRIDPNGDFIRRYLPVLRDFPAKYIYDP 450

  Fly   458 WKASLVDQRAYGCVLGTDYPHRIVKHEVVHKENIKRM-------------------------GAA 497
            |.|....|.|..||:|.|||..:|.|....:.||:||                         .||
Zfish   451 WNAPHDVQLAAKCVIGVDYPKPMVNHAEASRLNIERMRQIYQQLSRYRGLSLLATVPSNHIEDAA 515

  Fly   498 YKVNREV------RTGKEEESSFEEKSETSTSGKRKVRRATGSAPKRKR 540
            ..|||..      |..:.:.||:        :|.|:.:.....|..|.|
Zfish   516 ANVNRGAMAPPTRRKTRNDASSY--------TGVRREQPGPSGAKHRHR 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phr6-4	NP_001260632.1	PhrB	5..499	CDD:223492	247/520 (48%)
phr6-4	NP_001260632.1	FAD_binding_7	297..496	CDD:377037	113/223 (51%)
cry3b	XP_009294043.2	DNA_photolyase	5..494	CDD:332096	245/497 (49%)
cry3b	XP_009294043.2	FAD_binding_7	293..489	CDD:308829	113/195 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I3581
eggNOG	1	0.900	-	-		E1_COG0415
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63905
OrthoDB	1	1.010	-	-		D378952at2759
OrthoFinder	1	1.000	-	-		FOG0000663
OrthoInspector	1	1.000	-	-		otm25330
orthoMCL	1	0.900	-	-		OOG6_100453
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X403
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.730