DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment phr6-4 and cry4

DIOPT Version :9

Sequence 1:	NP_001260632.1	Gene:	phr6-4 / 35322	FlyBaseID:	FBgn0016054	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_005168334.1	Gene:	cry4 / 83775	ZFINID:	ZDB-GENE-010426-7	Length:	579	Species:	Danio rerio

Alignment Length:	567	Identity:	257/567 - (45%)
Similarity:	344/567 - (60%)	Gaps:	68/567 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VHWFRKGLRLHDNPALSHIFTAANAAPGKYFVRPIFILDPGILDW-MQVGANRWRFLQQTLEDLD 72
            :|.|||||||||||:|.....:::|      :.|:::||...|.. |.:||.|||||.|:|||||
Zfish    27 IHLFRKGLRLHDNPSLLGALASSSA------LYPVYVLDRVFLQGAMHMGALRWRFLLQSLEDLD 85

  Fly    73 NQLRKLNSRLFVVRGKPAEVFPRIFKSWRVEMLTFETDIEPYSVTRDAAVQKLAKAEGVRVETHC 137
            .:|:.:.|||||:.|..|.:...:...|.:..::::|::|||....|..:|.:|:..|::..|..
Zfish    86 TRLQAIGSRLFVLCGSTANILRELVAQWGITQISYDTEVEPYYTRMDKDIQTVAQENGLQTYTCV 150

  Fly   138 SHTIYNPELVIAKNLGKAPITYQKFLGIVEQLKVPKVLGVPEKLKNMPTPPKDEVEQKD------ 196
            |||:|:.:.::..|.|..|:||:|||.::      .|||.|||       |..:|..:|
Zfish   151 SHTLYDVKRIVKANGGSPPLTYKKFLHVL------SVLGEPEK-------PARDVSIEDFQRCVT 202

  Fly   197 ----SAAYDCPTMKQLVKRPEELGPNKFPGGETEALRRMEESLKDEIWVARFEKPNTAPNSLEPS 257
                ...|..|::..|..:.|  ....:||||:.||:|:|:..:.:.|||.|.||.|.||||.||
Zfish   203 PVDVDRVYAVPSLADLGLQVE--AEVLWPGGESHALQRLEKHFQSQGWVANFSKPRTIPNSLLPS 265

  Fly   258 TTVLSPYLKFGCLSARLFNQKLKEIIKRQPKHSQPPVSLIGQLMWREFYYTVAAAEPNFDRMLGN 322
            ||.|||||..||||.|.|..:|..|..:...||.|||||.||::||||:||||:|.|||.:|.||
Zfish   266 TTGLSPYLSLGCLSVRTFYHRLNSIYAQSKNHSLPPVSLQGQVLWREFFYTVASATPNFTKMEGN 330

  Fly   323 VYCMQIPWQEHPDHLEAWTHGRTGYPFIDAIMRQLRQEGWIHHLARHAVACFLTRGDLWISWEEG 387
            ..|:||.|...|:.||.|...:||:|:|||||.||||||||||||||||||||||||||||||||
Zfish   331 SICLQIDWYHDPERLEKWRTAQTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEG 395

  Fly   388 QRVFEQLLLDQDWALNAGNWMWLSASAFFHQYFRVYSPVAFGKKTDPQGHYIRKYVPELSKYPAG 452
            .:|||:.|||.|:::|||||||||||||||:|.|::.||.||::|||||.|:|||:|.|..:|:.
Zfish   396 MKVFEEFLLDADYSVNAGNWMWLSASAFFHKYTRIFCPVRFGRRTDPQGEYLRKYLPVLKNFPSQ 460

  Fly   453 CIYEPWKASLVDQRAYGCVLGTDYPHRIVKHEVVHKENIKRMGAAYKVNREVRTG---------- 507
            .|||||||....|.:.||::|.|||..||.|....:.|:..|       |:|||.
Zfish   461 YIYEPWKAPEDVQLSAGCIIGKDYPRPIVSHIEASQRNLALM-------RQVRTEQQTTAELTRD 518

  Fly   508 --------------KEEESSFEEKSETSTSGKRKVRRATGSAPKRKR 540
                          :|||...||.....||     :|.:||:..:.|
Zfish   519 VADDPMEAGLKRELREEEGLLEEAESQCTS-----KRFSGSSDHKSR 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phr6-4	NP_001260632.1	PhrB	5..499	CDD:223492	242/500 (48%)
phr6-4	NP_001260632.1	FAD_binding_7	297..496	CDD:377037	124/198 (63%)
cry4	XP_005168334.1	PhrB	26..506	CDD:223492	243/506 (48%)
		DNA_photolyase	26..189	CDD:279247	68/180 (38%)
		FAD_binding_7	231..504	CDD:281440	165/279 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	314	1.000	Domainoid score	I1263
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63905
OrthoDB	1	1.010	-	-		D378952at2759
OrthoFinder	1	1.000	-	-		FOG0000663
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100453
Panther	1	1.100	-	-	LDO	PTHR11455
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X403
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.930