DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment phr6-4 and cry-dash

DIOPT Version :9

Sequence 1:	NP_001260632.1	Gene:	phr6-4 / 35322	FlyBaseID:	FBgn0016054	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_991249.1	Gene:	cry-dash / 402986	ZFINID:	ZDB-GENE-040617-2	Length:	520	Species:	Danio rerio

Alignment Length:	477	Identity:	141/477 - (29%)
Similarity:	229/477 - (48%)	Gaps:	43/477 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SQRSTLVHWFRKGLRLHDNPALSHIFTAANAAPGKYFVRPIFILDP----GI--LDWMQVGANRW 61
            |...|::...|..||||||....  :...||.    .:.|::..||    |.  .::.:.|..|.
Zfish     2 SASRTVICLLRNDLRLHDNEVFH--WAQRNAE----HIIPLYCFDPRHYQGTYHYNFPKTGPFRL 60

  Fly    62 RFLQQTLEDLDNQLRKLNSRLFVVRGKPAEVFPRIFKS-WRVEMLTFETDIEPYSVTRDAAVQKL 125
            |||..:::||...|:|..|.|.|.:|||.:|...:.|. ..|..:.|..::.....:.:..::::
Zfish    61 RFLLDSVKDLRALLKKHGSTLLVRQGKPEDVVCELIKQLGSVSTVAFHEEVASEEKSVEEKLKEI 125

  Fly   126 AKAEGVRVETHCSHTIYNPELVIAKNLGKAPITYQKFLGIVE-QLKVPKVLGVPEKLKNMPT--- 186
            .....|||:|....|:|:.:.:...::|..|..|.:|...|| |.:|..||..||::|:.|:
Zfish   126 CCQNKVRVQTFWGSTLYHRDDLPFSHIGGLPDVYTQFRKAVEAQGRVRPVLSTPEQVKSPPSGLE 190

  Fly   187 ----PPKDEVEQKDSAAYDCPTMKQLVKRPEELGPNKFP--GGETEALRRMEESLKDEIWVARFE 245
                |..|.:.|.:... ||              .:.||  |||||||.|::....|...||.::
Zfish   191 EGPIPTFDSLGQTEPLD-DC--------------RSAFPCRGGETEALARLKHYFWDTNAVATYK 240

  Fly   246 KPNTAPNSLEPSTTVLSPYLKFGCLSARLFNQKLKEI-IKRQPKHSQPPVSLIGQLMWREFYYTV 309
            :.......::.||. .||:|..||:|.|...:::|:. ::|..  :|....:|.:|:||:::..|
Zfish   241 ETRNGMIGVDFSTK-FSPWLALGCISPRYIYEQIKKYEVERTA--NQSTYWVIFELLWRDYFKFV 302

  Fly   310 AAAEPNFDRMLGNVYCMQIPWQEHPDHLEAWTHGRTGYPFIDAIMRQLRQEGWIHHLARHAVACF 374
            |....|....:..:....:||:......:||..||||.||:||.||:|...|::.:..|..||.|
Zfish   303 ALKYGNRIFYMNGLQDKHVPWKTDMKMFDAWKEGRTGVPFVDANMRELALTGFMSNRGRQNVASF 367

  Fly   375 LTRGDLWISWEEGQRVFEQLLLDQDWALNAGNWMWLSASAFFHQYFRVYSPVAFGKKTDPQGHYI 439
            ||: ||.:.|..|...||.||:|.|...|.|||::.:......:..|.::.:..|...|..|.|:
Zfish   368 LTK-DLGLDWRLGAEWFEYLLVDHDVCSNYGNWLYSAGIGNDPRENRKFNMIKQGLDYDNNGDYV 431

  Fly   440 RKYVPELSKYPAGCIYEPWKAS 461
            |::||||.....|.::.||..|
Zfish   432 RQWVPELRGIKGGDVHTPWTLS 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phr6-4	NP_001260632.1	PhrB	5..499	CDD:223492	140/475 (29%)
phr6-4	NP_001260632.1	FAD_binding_7	297..496	CDD:377037	57/165 (35%)
cry-dash	NP_991249.1	crypto_DASH	5..438	CDD:274288	134/457 (29%)
		DNA_photolyase	7..174	CDD:279247	46/172 (27%)
		FAD_binding_7	218..473	CDD:281440	79/240 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	479..504
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0415
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D378952at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X403
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820