Protein Alignment phr6-4 and Cry2

DIOPT Version :10

• Sequence 1: NP_477188.1
• Gene: phr6-4 / 35322
• FlyBaseID: FBgn0016054
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_596896.2
• Gene: Cry2 / 170917
• RGDID: 620935
• Length: 594
• Species: Rattus norvegicus
• Alignment Length: 557
• Identity: 274/557 - (49%)
• Similarity: 361/557 - (64%)
• Gaps: 29/557 - (5%)

  Fly     1 MDSQRSTLVHWFRKGLRLHDNPALSHIFTAANAAPGKYFVRPIFILDPGILDWMQVGANRWRFLQ 65
            |.:..::.||||||||||||||||      ..|..|...||.::||||.......||.||||||.
  Rat    16 MGADGASSVHWFRKGLRLHDNPAL------LAAVRGARCVRCVYILDPWFAASSSVGINRWRFLL 74

  Fly    66 QTLEDLDNQLRKLNSRLFVVRGKPAEVFPRIFKSWRVEMLTFETDIEPYSVTRDAAVQKLAKAEG 130
            |:|||||..|||||||||||||:||:||||:||.|.|..||||.|.||:...||||:.|:||..|
  Rat    75 QSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFKEWGVTRLTFEYDSEPFGKERDAAIMKMAKEAG 139

  Fly   131 VRVETHCSHTIYNPELVIAKNLGKAPITYQKFLGIVEQLKVP-KVLGV--PEKLKNMPTPPKDEV 192
            |.|.|..|||:|:.:.:|..|..|.|:||::|..::.::::| |.:|.  .:.::|.    :.|:
  Rat   140 VEVVTENSHTLYDLDRIIELNGQKPPLTYKRFQALISRMELPKKPVGAVSSQHMENC----RAEI 200

  Fly   193 EQKDSAAYDCPTMKQLVKRPEELGPNKFPGGETEALRRMEESLKDEIWVARFEKPNTAPNSLEPS 257
            ::.....|..|::::|....|.|||..:.|||||||.|:::.|:.:.|||.:|:|....|||..|
  Rat   201 QENHDDTYGVPSLEELGFPTEGLGPAVWQGGETEALARLDKHLERKAWVANYERPRMNANSLLAS 265

  Fly   258 TTVLSPYLKFGCLSARLFNQKLKEIIKRQPKHSQPPVSLIGQLMWREFYYTVAAAEPNFDRMLGN 322
            .|.|||||:|||||.|||..:|.::.::..::|.||:||.|||:||||:||.|...|.||||.||
  Rat   266 PTGLSPYLRFGCLSCRLFYYRLWDLYRKVKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGN 330

  Fly   323 VYCMQIPWQEHPDHLEAWTHGRTGYPFIDAIMRQLRQEGWIHHLARHAVACFLTRGDLWISWEEG 387
            ..|:||||..:|:.|..|..|:||:|:|||||.||||||||||||||||||||||||||:|||.|
  Rat   331 PICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESG 395

  Fly   388 QRVFEQLLLDQDWALNAGNWMWLSASAFFHQYFRVYSPVAFGKKTDPQGHYIRKYVPELSKYPAG 452
            .|||::||||.|:::|||:|||||.||||.|:|..|.||.||::|||.|.|||:|:|:|..:|:.
  Rat   396 VRVFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIRRYLPKLKGFPSR 460

  Fly   453 CIYEPWKASLVDQRAYGCVLGTDYPHRIVKHEVVHKENIKRMGAAYKVNREVR------------ 505
            .|||||.|....|:|..|::|.|||..||.|....:.||:||...|:.....|
  Rat   461 YIYEPWNAPESVQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGLCLLASVPSCV 525

  Fly   506 ---TGKEEESSFEEKSETSTSGKRKVRRATGSAPKRK 539
               :....|....:....|.:|.|.:.....| ||||
  Rat   526 EDLSHPVAEPGSSQAGSISNTGPRPLSSGPAS-PKRK 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phr6-4	NP_477188.1	PhrB	6..497	CDD:440184	262/493 (53%)
Cry2	NP_596896.2	PhrB	23..505	CDD:440184	262/491 (53%)
		Required for inhibition of CLOCK-BMAL1-mediated transcription. /evidence=ECO:0000250|UniProtKB:Q9R194	389..488		56/98 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	532..594		9/31 (29%)