Protein Alignment phr6-4 and CRY2

DIOPT Version :9

• Sequence 1: NP_001260632.1
• Gene: phr6-4 / 35322
• FlyBaseID: FBgn0016054
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_066940.3
• Gene: CRY2 / 1408
• HGNCID: 2385
• Length: 593
• Species: Homo sapiens
• Alignment Length: 556
• Identity: 278/556 - (50%)
• Similarity: 362/556 - (65%)
• Gaps: 31/556 - (5%)

  Fly     2 DSQRSTLVHWFRKGLRLHDNPALSHIFTAANAAPGKYFVRPIFILDPGILDWMQVGANRWRFLQQ 66
            ||..|  ||||||||||||||||      ..|..|...||.::||||.......||.||||||.|
Human    20 DSASS--VHWFRKGLRLHDNPAL------LAAVRGARCVRCVYILDPWFAASSSVGINRWRFLLQ 76

  Fly    67 TLEDLDNQLRKLNSRLFVVRGKPAEVFPRIFKSWRVEMLTFETDIEPYSVTRDAAVQKLAKAEGV 131
            :|||||..|||||||||||||:||:||||:||.|.|..||||.|.||:...||||:.|:||..||
Human    77 SLEDLDTSLRKLNSRLFVVRGQPADVFPRLFKEWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGV 141

  Fly   132 RVETHCSHTIYNPELVIAKNLGKAPITYQKFLGIVEQLKVPKV---LGVPEKLKNMPTPPKDEVE 193
            .|.|..|||:|:.:.:|..|..|.|:||::|..|:.::::||.   |...:::::.    :.|::
Human   142 EVVTENSHTLYDLDRIIELNGQKPPLTYKRFQAIISRMELPKKPVGLVTSQQMESC----RAEIQ 202

  Fly   194 QKDSAAYDCPTMKQLVKRPEELGPNKFPGGETEALRRMEESLKDEIWVARFEKPNTAPNSLEPST 258
            :.....|..|::::|....|.|||..:.|||||||.|:::.|:.:.|||.:|:|....|||..|.
Human   203 ENHDETYGVPSLEELGFPTEGLGPAVWQGGETEALARLDKHLERKAWVANYERPRMNANSLLASP 267

  Fly   259 TVLSPYLKFGCLSARLFNQKLKEIIKRQPKHSQPPVSLIGQLMWREFYYTVAAAEPNFDRMLGNV 323
            |.|||||:|||||.|||..:|.::.|:..::|.||:||.|||:||||:||.|...|.||||.||.
Human   268 TGLSPYLRFGCLSCRLFYYRLWDLYKKVKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNP 332

  Fly   324 YCMQIPWQEHPDHLEAWTHGRTGYPFIDAIMRQLRQEGWIHHLARHAVACFLTRGDLWISWEEGQ 388
            .|:||||..:|:.|..|..|:||:|:|||||.||||||||||||||||||||||||||:|||.|.
Human   333 ICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGV 397

  Fly   389 RVFEQLLLDQDWALNAGNWMWLSASAFFHQYFRVYSPVAFGKKTDPQGHYIRKYVPELSKYPAGC 453
            |||::||||.|:::|||:|||||.||||.|:|..|.||.||::|||.|.|||:|:|:|..:|:..
Human   398 RVFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIRRYLPKLKAFPSRY 462

  Fly   454 IYEPWKASLVDQRAYGCVLGTDYPHRIVKHEVVHKENIKRMGAAYKVNREVR------------- 505
            |||||.|....|:|..|::|.|||..||.|....:.||:||...|:.....|
Human   463 IYEPWNAPESIQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGLCLLASVPSCVE 527

  Fly   506 --TGKEEESSFEEKSETSTSGKRKVRRATGSAPKRK 539
              :....|.|..:....|::|.|.:.....| ||||
Human   528 DLSHPVAEPSSSQAGSMSSAGPRPLPSGPAS-PKRK 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phr6-4	NP_001260632.1	PhrB	5..499	CDD:223492	264/496 (53%)
		FAD_binding_7	297..496	CDD:377037	122/198 (62%)
CRY2	NP_066940.3	PhrB	22..510	CDD:223492	265/499 (53%)
		FAD_binding_7	307..505	CDD:308829	122/197 (62%)
		Required for inhibition of CLOCK-ARNTL-mediated transcription. /evidence=ECO:0000250|UniProtKB:Q9R194	390..489		56/98 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	532..593		10/32 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	282	1.000	Domainoid score	I1663
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	545	1.000	Inparanoid score	I1165
Isobase	1	0.950	-	0.878984	Normalized mean entropy	S3590
OMA	1	1.010	-	-		QHG63905
OrthoDB	1	1.010	-	-		D378952at2759
OrthoFinder	1	1.000	-	-		FOG0000663
OrthoInspector	1	1.000	-	-		otm40565
orthoMCL	1	0.900	-	-		OOG6_100453
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2229
SonicParanoid	1	1.000	-	-		X403
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.860