DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment phr6-4 and CRY1

DIOPT Version :9

Sequence 1:	NP_001260632.1	Gene:	phr6-4 / 35322	FlyBaseID:	FBgn0016054	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_024304612.1	Gene:	CRY1 / 1407	HGNCID:	2384	Length:	632	Species:	Homo sapiens

Alignment Length:	494	Identity:	261/494 - (52%)
Similarity:	337/494 - (68%)	Gaps:	13/494 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VHWFRKGLRLHDNPALSHIFTAANAAPGKYFVRPIFILDPGILDWMQVGANRWRFLQQTLEDLDN 73
            ||||||||||||||||......|:.      :|.::||||.......||.||||||.|.|||||.
Human     6 VHWFRKGLRLHDNPALKECIQGADT------IRCVYILDPWFAGSSNVGINRWRFLLQCLEDLDA 64

  Fly    74 QLRKLNSRLFVVRGKPAEVFPRIFKSWRVEMLTFETDIEPYSVTRDAAVQKLAKAEGVRVETHCS 138
            .||||||||||:||:||:||||:||.|.:..|:.|.|.||:...||||::|||...||.|....|
Human    65 NLRKLNSRLFVIRGQPADVFPRLFKEWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRIS 129

  Fly   139 HTIYNPELVIAKNLGKAPITYQKFLGIV---EQLKVPKVLGVPEKLKNMPTPPKDEVEQKDSAAY 200
            ||:|:.:.:|..|.|:.|:||::|..::   |.|::|......|.::...||..|:.::|    |
Human   130 HTLYDLDKIIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVIEKCTTPLSDDHDEK----Y 190

  Fly   201 DCPTMKQLVKRPEELGPNKFPGGETEALRRMEESLKDEIWVARFEKPNTAPNSLEPSTTVLSPYL 265
            ..|::::|....:.|....:||||||||.|:|..|:.:.|||.||:|....|||..|.|.|||||
Human   191 GVPSLEELGFDTDGLSSAVWPGGETEALTRLERHLERKAWVANFERPRMNANSLLASPTGLSPYL 255

  Fly   266 KFGCLSARLFNQKLKEIIKRQPKHSQPPVSLIGQLMWREFYYTVAAAEPNFDRMLGNVYCMQIPW 330
            :|||||.|||..||.::.|:..|:|.||:||.|||:||||:||.|...|.||:|.||..|:||||
Human   256 RFGCLSCRLFYFKLTDLYKKVKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPW 320

  Fly   331 QEHPDHLEAWTHGRTGYPFIDAIMRQLRQEGWIHHLARHAVACFLTRGDLWISWEEGQRVFEQLL 395
            .::|:.|..|..||||:|:|||||.||||||||||||||||||||||||||||||||.:|||:||
Human   321 DKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMKVFEELL 385

  Fly   396 LDQDWALNAGNWMWLSASAFFHQYFRVYSPVAFGKKTDPQGHYIRKYVPELSKYPAGCIYEPWKA 460
            ||.||::|||:|||||.|:||.|:|..|.||.||::|||.|.|||:|:|.|..:||..||:||.|
Human   386 LDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIRRYLPVLRGFPAKYIYDPWNA 450

  Fly   461 SLVDQRAYGCVLGTDYPHRIVKHEVVHKENIKRMGAAYK 499
            ....|:...|::|.:||..:|.|....:.||:||...|:
Human   451 PEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQ 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phr6-4	NP_001260632.1	PhrB	5..499	CDD:223492	260/492 (53%)
phr6-4	NP_001260632.1	FAD_binding_7	297..496	CDD:377037	121/198 (61%)
CRY1	XP_024304612.1	PhrB	6..491	CDD:223492	261/494 (53%)
CRY1	XP_024304612.1	FAD_binding_7	288..486	CDD:308829	121/197 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	282	1.000	Domainoid score	I1663
eggNOG	1	0.900	-	-		E1_COG0415
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	545	1.000	Inparanoid score	I1165
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63905
OrthoDB	1	1.010	-	-		D378952at2759
OrthoFinder	1	1.000	-	-		FOG0000663
OrthoInspector	1	1.000	-	-		otm40565
orthoMCL	1	0.900	-	-		OOG6_100453
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2229
SonicParanoid	1	1.000	-	-		X403
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.810