Protein Alignment phr6-4 and Cry2

DIOPT Version :10

• Sequence 1: NP_477188.1
• Gene: phr6-4 / 35322
• FlyBaseID: FBgn0016054
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_034093.1
• Gene: Cry2 / 12953
• MGIID: 1270859
• Length: 592
• Species: Mus musculus
• Alignment Length: 554
• Identity: 275/554 - (49%)
• Similarity: 359/554 - (64%)
• Gaps: 23/554 - (4%)

  Fly     1 MDSQRSTLVHWFRKGLRLHDNPALSHIFTAANAAPGKYFVRPIFILDPGILDWMQVGANRWRFLQ 65
            |.:..::.||||||||||||||||      ..|..|...||.::||||.......||.||||||.
Mouse    16 MGADGASSVHWFRKGLRLHDNPAL------LAAVRGARCVRCVYILDPWFAASSSVGINRWRFLL 74

  Fly    66 QTLEDLDNQLRKLNSRLFVVRGKPAEVFPRIFKSWRVEMLTFETDIEPYSVTRDAAVQKLAKAEG 130
            |:|||||..|||||||||||||:||:||||:||.|.|..||||.|.||:...||||:.|:||..|
Mouse    75 QSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFKEWGVTRLTFEYDSEPFGKERDAAIMKMAKEAG 139

  Fly   131 VRVETHCSHTIYNPELVIAKNLGKAPITYQKFLGIVEQLKVPKVLGVPEKLKNMPTPPKDEVEQK 195
            |.|.|..|||:|:.:.:|..|..|.|:||::|..::.::::||...|....:.|.: .:.|:::.
Mouse   140 VEVVTENSHTLYDLDRIIELNGQKPPLTYKRFQALISRMELPKKPAVAVSSQQMES-CRAEIQEN 203

  Fly   196 DSAAYDCPTMKQLVKRPEELGPNKFPGGETEALRRMEESLKDEIWVARFEKPNTAPNSLEPSTTV 260
            ....|..|::::|....|.|||..:.|||||||.|:::.|:.:.|||.:|:|....|||..|.|.
Mouse   204 HDDTYGVPSLEELGFPTEGLGPAVWQGGETEALARLDKHLERKAWVANYERPRMNANSLLASPTG 268

  Fly   261 LSPYLKFGCLSARLFNQKLKEIIKRQPKHSQPPVSLIGQLMWREFYYTVAAAEPNFDRMLGNVYC 325
            |||||:|||||.|||..:|.::.|:..::|.||:||.|||:||||:||.|...|.||||.||..|
Mouse   269 LSPYLRFGCLSCRLFYYRLWDLYKKVKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPIC 333

  Fly   326 MQIPWQEHPDHLEAWTHGRTGYPFIDAIMRQLRQEGWIHHLARHAVACFLTRGDLWISWEEGQRV 390
            :||||..:|:.|..|..|:||:|:|||||.||||||||||||||||||||||||||:|||.|.||
Mouse   334 IQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVRV 398

  Fly   391 FEQLLLDQDWALNAGNWMWLSASAFFHQYFRVYSPVAFGKKTDPQGHYIRKYVPELSKYPAGCIY 455
            |::||||.|:::|||:|||||.||||.|:|..|.||.||::|||.|.|||:|:|:|..:|:..||
Mouse   399 FDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIRRYLPKLKGFPSRYIY 463

  Fly   456 EPWKASLVDQRAYGCVLGTDYPHRIVKHEVVHKENIKRMGAAYKVNREVR--------------- 505
            |||.|....|:|..|::|.|||..||.|....:.||:||...|:.....|
Mouse   464 EPWNAPESVQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGLCLLASVPSCVEDL 528

  Fly   506 TGKEEESSFEEKSETSTSGKRKVRRATGSAPKRK 539
            :....|....:....|.:|.|.:.....| ||||
Mouse   529 SHPVAEPGSSQAGSISNTGPRALSSGPAS-PKRK 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
phr6-4	NP_477188.1	PhrB	6..497	CDD:440184	263/490 (54%)
Cry2	NP_034093.1	PhrB	23..505	CDD:440184	263/488 (54%)
		Required for inhibition of CLOCK-BMAL1-mediated transcription. /evidence=ECO:0000250|UniProtKB:P97784	389..488		56/98 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	532..592		9/31 (29%)