DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment phr6-4 and Cry2

DIOPT Version :9

Sequence 1:NP_001260632.1 Gene:phr6-4 / 35322 FlyBaseID:FBgn0016054 Length:540 Species:Drosophila melanogaster
Sequence 2:NP_034093.1 Gene:Cry2 / 12953 MGIID:1270859 Length:592 Species:Mus musculus


Alignment Length:554 Identity:275/554 - (49%)
Similarity:359/554 - (64%) Gaps:23/554 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDSQRSTLVHWFRKGLRLHDNPALSHIFTAANAAPGKYFVRPIFILDPGILDWMQVGANRWRFLQ 65
            |.:..::.||||||||||||||||      ..|..|...||.::||||.......||.||||||.
Mouse    16 MGADGASSVHWFRKGLRLHDNPAL------LAAVRGARCVRCVYILDPWFAASSSVGINRWRFLL 74

  Fly    66 QTLEDLDNQLRKLNSRLFVVRGKPAEVFPRIFKSWRVEMLTFETDIEPYSVTRDAAVQKLAKAEG 130
            |:|||||..|||||||||||||:||:||||:||.|.|..||||.|.||:...||||:.|:||..|
Mouse    75 QSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFKEWGVTRLTFEYDSEPFGKERDAAIMKMAKEAG 139

  Fly   131 VRVETHCSHTIYNPELVIAKNLGKAPITYQKFLGIVEQLKVPKVLGVPEKLKNMPTPPKDEVEQK 195
            |.|.|..|||:|:.:.:|..|..|.|:||::|..::.::::||...|....:.|.: .:.|:::.
Mouse   140 VEVVTENSHTLYDLDRIIELNGQKPPLTYKRFQALISRMELPKKPAVAVSSQQMES-CRAEIQEN 203

  Fly   196 DSAAYDCPTMKQLVKRPEELGPNKFPGGETEALRRMEESLKDEIWVARFEKPNTAPNSLEPSTTV 260
            ....|..|::::|....|.|||..:.|||||||.|:::.|:.:.|||.:|:|....|||..|.|.
Mouse   204 HDDTYGVPSLEELGFPTEGLGPAVWQGGETEALARLDKHLERKAWVANYERPRMNANSLLASPTG 268

  Fly   261 LSPYLKFGCLSARLFNQKLKEIIKRQPKHSQPPVSLIGQLMWREFYYTVAAAEPNFDRMLGNVYC 325
            |||||:|||||.|||..:|.::.|:..::|.||:||.|||:||||:||.|...|.||||.||..|
Mouse   269 LSPYLRFGCLSCRLFYYRLWDLYKKVKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPIC 333

  Fly   326 MQIPWQEHPDHLEAWTHGRTGYPFIDAIMRQLRQEGWIHHLARHAVACFLTRGDLWISWEEGQRV 390
            :||||..:|:.|..|..|:||:|:|||||.||||||||||||||||||||||||||:|||.|.||
Mouse   334 IQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSWESGVRV 398

  Fly   391 FEQLLLDQDWALNAGNWMWLSASAFFHQYFRVYSPVAFGKKTDPQGHYIRKYVPELSKYPAGCIY 455
            |::||||.|:::|||:|||||.||||.|:|..|.||.||::|||.|.|||:|:|:|..:|:..||
Mouse   399 FDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIRRYLPKLKGFPSRYIY 463

  Fly   456 EPWKASLVDQRAYGCVLGTDYPHRIVKHEVVHKENIKRMGAAYKVNREVR--------------- 505
            |||.|....|:|..|::|.|||..||.|....:.||:||...|:.....|               
Mouse   464 EPWNAPESVQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRYRGLCLLASVPSCVEDL 528

  Fly   506 TGKEEESSFEEKSETSTSGKRKVRRATGSAPKRK 539
            :....|....:....|.:|.|.:.....| ||||
Mouse   529 SHPVAEPGSSQAGSISNTGPRALSSGPAS-PKRK 561

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
phr6-4NP_001260632.1 PhrB 5..499 CDD:223492 263/493 (53%)
FAD_binding_7 297..496 CDD:377037 122/198 (62%)
Cry2NP_034093.1 PhrB 21..509 CDD:223492 264/494 (53%)
FAD_binding_7 306..504 CDD:377037 122/197 (62%)
Required for inhibition of CLOCK-ARNTL-mediated transcription. /evidence=ECO:0000250|UniProtKB:P97784 389..488 56/98 (57%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 532..592 9/31 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 281 1.000 Domainoid score I1663
eggNOG 1 0.900 - - E1_COG0415
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 549 1.000 Inparanoid score I1137
Isobase 1 0.950 - 0.878984 Normalized mean entropy S3590
OMA 1 1.010 - - QHG63905
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000663
OrthoInspector 1 1.000 - - otm42636
orthoMCL 1 0.900 - - OOG6_100453
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2229
SonicParanoid 1 1.000 - - X403
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1211.750

Return to query results.
Submit another query.