DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment phr6-4 and Cry1

DIOPT Version :9

Sequence 1:	NP_001260632.1	Gene:	phr6-4 / 35322	FlyBaseID:	FBgn0016054	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_031797.1	Gene:	Cry1 / 12952	MGIID:	1270841	Length:	606	Species:	Mus musculus

Alignment Length:	494	Identity:	261/494 - (52%)
Similarity:	336/494 - (68%)	Gaps:	13/494 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VHWFRKGLRLHDNPALSHIFTAANAAPGKYFVRPIFILDPGILDWMQVGANRWRFLQQTLEDLDN 73
            ||||||||||||||||......|:.      :|.::||||.......||.||||||.|.|||||.
Mouse     6 VHWFRKGLRLHDNPALKECIQGADT------IRCVYILDPWFAGSSNVGINRWRFLLQCLEDLDA 64

  Fly    74 QLRKLNSRLFVVRGKPAEVFPRIFKSWRVEMLTFETDIEPYSVTRDAAVQKLAKAEGVRVETHCS 138
            .||||||||||:||:||:||||:||.|.:..|:.|.|.||:...||||::|||...||.|....|
Mouse    65 NLRKLNSRLFVIRGQPADVFPRLFKEWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIVRIS 129

  Fly   139 HTIYNPELVIAKNLGKAPITYQKFLGIV---EQLKVPKVLGVPEKLKNMPTPPKDEVEQKDSAAY 200
            ||:|:.:.:|..|.|:.|:||::|..:|   |.|::|......:.:....||..|:.::|    |
Mouse   130 HTLYDLDKIIELNGGQPPLTYKRFQTLVSKMEPLEMPADTITSDVIGKCMTPLSDDHDEK----Y 190

  Fly   201 DCPTMKQLVKRPEELGPNKFPGGETEALRRMEESLKDEIWVARFEKPNTAPNSLEPSTTVLSPYL 265
            ..|::::|....:.|....:||||||||.|:|..|:.:.|||.||:|....|||..|.|.|||||
Mouse   191 GVPSLEELGFDTDGLSSAVWPGGETEALTRLERHLERKAWVANFERPRMNANSLLASPTGLSPYL 255

  Fly   266 KFGCLSARLFNQKLKEIIKRQPKHSQPPVSLIGQLMWREFYYTVAAAEPNFDRMLGNVYCMQIPW 330
            :|||||.|||..||.::.|:..|:|.||:||.|||:||||:||.|...|.||:|.||..|:||||
Mouse   256 RFGCLSCRLFYFKLTDLYKKVKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPW 320

  Fly   331 QEHPDHLEAWTHGRTGYPFIDAIMRQLRQEGWIHHLARHAVACFLTRGDLWISWEEGQRVFEQLL 395
            .::|:.|..|..||||:|:|||||.||||||||||||||||||||||||||||||||.:|||:||
Mouse   321 DKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMKVFEELL 385

  Fly   396 LDQDWALNAGNWMWLSASAFFHQYFRVYSPVAFGKKTDPQGHYIRKYVPELSKYPAGCIYEPWKA 460
            ||.||::|||:|||||.|:||.|:|..|.||.||::|||.|.|||:|:|.|..:||..||:||.|
Mouse   386 LDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIRRYLPVLRGFPAKYIYDPWNA 450

  Fly   461 SLVDQRAYGCVLGTDYPHRIVKHEVVHKENIKRMGAAYK 499
            ....|:...|::|.:||..:|.|....:.||:||...|:
Mouse   451 PEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQ 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phr6-4	NP_001260632.1	PhrB	5..499	CDD:223492	260/492 (53%)
phr6-4	NP_001260632.1	FAD_binding_7	297..496	CDD:377037	121/198 (61%)
Cry1	NP_031797.1	DNA_photolyase	5..167	CDD:279247	86/166 (52%)
		PhrB	6..491	CDD:223492	261/494 (53%)
		LIR 1. /evidence=ECO:0000305\|PubMed:29937374	50..54		3/3 (100%)
		LIR 2. /evidence=ECO:0000305\|PubMed:29937374	82..87		3/4 (75%)
		LIR 3. /evidence=ECO:0000305\|PubMed:29937374	151..156		1/4 (25%)
		FAD_binding_7	213..486	CDD:281440	163/272 (60%)
		LIR 4. /evidence=ECO:0000305\|PubMed:29937374	255..260		3/4 (75%)
		LIR 5. /evidence=ECO:0000305\|PubMed:29937374	271..276		1/4 (25%)
		LIR 6. /evidence=ECO:0000305\|PubMed:29937374	285..290		3/4 (75%)
		LIR 7. /evidence=ECO:0000305\|PubMed:29937374	335..339		2/3 (67%)
		Required for inhibition of CLOCK-ARNTL/BMAL1-mediated transcription. /evidence=ECO:0000269\|PubMed:16478995	371..470		56/98 (57%)
		LIR 8. /evidence=ECO:0000305\|PubMed:29937374	379..384		3/4 (75%)
		LIR 9. /evidence=ECO:0000305\|PubMed:29937374	395..400		3/4 (75%)
		LIR 10. /evidence=ECO:0000305\|PubMed:29937374	411..416		1/4 (25%)
		LIR 11. /evidence=ECO:0000305\|PubMed:29937374	430..435		2/4 (50%)
		Interaction with TIMELESS. /evidence=ECO:0000269\|PubMed:23418588	471..493		7/19 (37%)
		LIR 12. /evidence=ECO:0000305\|PubMed:29937374	486..491		1/4 (25%)
		LIR 13. /evidence=ECO:0000305\|PubMed:29937374	492..497
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	559..606
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	281	1.000	Domainoid score	I1663
eggNOG	1	0.900	-	-		E1_COG0415
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	549	1.000	Inparanoid score	I1137
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63905
OrthoDB	1	1.010	-	-		D378952at2759
OrthoFinder	1	1.000	-	-		FOG0000663
OrthoInspector	1	1.000	-	-		otm42636
orthoMCL	1	0.900	-	-		OOG6_100453
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2229
SonicParanoid	1	1.000	-	-		X403
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.810