DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment phr6-4 and cry-dash

DIOPT Version :9

Sequence 1:	NP_001260632.1	Gene:	phr6-4 / 35322	FlyBaseID:	FBgn0016054	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_031759840.1	Gene:	cry-dash / 100487730	XenbaseID:	XB-GENE-5887316	Length:	523	Species:	Xenopus tropicalis

Alignment Length:	569	Identity:	155/569 - (27%)
Similarity:	255/569 - (44%)	Gaps:	89/569 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSQRSTLVHWFRKGLRLHDNPALSHIFTAANAAPGKYFVRPIFILDP------GILDWMQVGAN 59
            |.::...::...|..||||||..|......|:.      :.|::..||      ...::.:.|.:
Frog     1 MAARARVIICLLRNDLRLHDNEVLHWAHRNADQ------IVPLYCFDPRHYGGTHYFNFPKTGPH 59

  Fly    60 RWRFLQQTLEDLDNQLRKLNSRLFVVRGKPAEVFPRIFKS-WRVEMLTF-------ETDIEPYSV 116
            |.:||.::::||.|.|::..|.|.:.||||.|:...:.|. ..|..:|.       |||:|
Frog    60 RLKFLLESVQDLRNTLKERGSNLLLRRGKPEEIIAGLVKQLGNVSAVTLHEEATKEETDVE---- 120

  Fly   117 TRDAAVQKLAKAEGVRVETHCSHTIYNPELVIAKNLGKAPITYQKFLGIVE-QLKVPKVLGVPEK 180
               :||:::....|||.:|....|:|:.|.:..:::...|..|.:|....| |.||.....:|::
Frog   121 ---SAVRRVCTQLGVRYQTFWGSTLYHREDLPFRHISSLPDVYTQFRKAAETQGKVRSTFQMPDR 182

  Fly   181 LKNMPT-------PPKDEVEQKD-----SAAYDCPTMKQLVKRPEELGPNKFPGGETEALRRMEE 233
            ||.:|:       |...:.:|:|     .:|:.|                  .||||:||:|:..
Frog   183 LKPLPSGLEEGSVPTHQDFDQQDPLTDPRSAFPC------------------CGGETQALQRLHH 229

  Fly   234 SLKDEIWVARFEKPNTAPNSLEPSTTVLSPYLKFGCLSARLFNQKLKEIIKRQPKHSQPPVSLIG 298
            ...:...||.::........::.||. .:|:|..||:|.|...:::::..|.:.. :|....:|.
Frog   230 YFWETNLVASYKDTRNGLIGIDYSTK-FAPWLALGCISPRYIYEQIRKYEKERTA-NQSTYWVIF 292

  Fly   299 QLMWREFYYTVAAAEPNFDRMLGNVYCMQIPWQEHPDHLEAWTHGRTGYPFIDAIMRQLRQEGWI 363
            :|:||:::..||.........|..:....:||::.|...:||..||||.||:||.||:|...|::
Frog   293 ELLWRDYFRFVALKYGRRIFFLRGLQDKDVPWKKDPKLFDAWKEGRTGVPFVDANMRELAMTGFM 357

  Fly   364 HHLARHAVACFLTRGDLWISWEEGQRVFEQLLLDQDWALNAGNWMWLSASAFFHQYFRVYSPVAF 428
            .:..|..||.|||: ||.|.|..|...||.||:|.|...|.|||::.:......:..|.::.:..
Frog   358 SNRGRQNVASFLTK-DLXIDWRLGAEWFEYLLVDYDVCSNYGNWLYSAGIGNDPRENRKFNMIKQ 421

  Fly   429 GKKTDPQGHYIRKYVPELSKYPAGCIYEPWKASLVDQRAYGCVLGTDYPHRIVKHEVVHKENIKR 493
            |...|..|.|||.:||||.:...|..:.||..|..........||..||:.||
Frog   422 GLDYDAGGDYIRLWVPELQQIKGGDAHTPWALSTASLAHSNVSLGETYPYPIV------------ 474

  Fly   494 MGAAYKVNREVRTGKEEESSFEEKSETSTSGKRKVRRATGSA--PKRKR 540
              .|.:.:|.:            ..:.|.|.:...||..|.:  ||:.|
Frog   475 --MAPEWSRHI------------NQKPSGSWETSARRGKGPSHTPKQHR 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phr6-4	NP_001260632.1	PhrB	5..499	CDD:223492	145/520 (28%)
phr6-4	NP_001260632.1	FAD_binding_7	297..496	CDD:377037	66/198 (33%)
cry-dash	XP_031759840.1	crypto_DASH	6..439	CDD:274288	132/466 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D378952at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X403
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920