DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2493 and Dpp7

DIOPT Version :9

Sequence 1:	NP_001260630.1	Gene:	CG2493 / 35316	FlyBaseID:	FBgn0032864	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_114031.2	Gene:	Dpp7 / 83768	MGIID:	1933213	Length:	506	Species:	Mus musculus

Alignment Length:	480	Identity:	185/480 - (38%)
Similarity:	261/480 - (54%)	Gaps:	38/480 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 VLGILLIAG-CDCSQRF------KYEIKEFQVPLDHFSF--LINATFNIRYLYNDSFVDKSNART 73
            :|.:||..| |:...|.      .:....|:..:|||:|  ..|.||..|:|.:|.|......
Mouse    17 ILVLLLSLGLCNLQARADRVLDPDFHENYFEQYMDHFNFESFGNKTFGQRFLVSDKFWKMGEG-- 79

  Fly    74 PIFFYTGNEGDIELFAQNTGFLWEQAERQRALVIFAEHRYYGKSLPFGSSTFNTSLPEHLAYFTV 138
            ||||||||||||..||.|:||:.|.|.:|.||::||||||||||||||..:......:.|   ||
Mouse    80 PIFFYTGNEGDIWSFANNSGFMVELAAQQEALLVFAEHRYYGKSLPFGVQSTQRGYTQLL---TV 141

  Fly   139 EQTLEDYAMLITFLRND---RQMPVVAFGGSYGGMLAAWFRMKYPHLVNGALAASAPVLQFPGIT 200
            ||.|.|:|:|:..||.|   ...|.:||||||||||:|:.||||||||.|||||||||:...|:.
Mouse   142 EQALADFAVLLQALRQDLGVHDAPTIAFGGSYGGMLSAYMRMKYPHLVAGALAASAPVVAVAGLG 206

  Fly   201 DCDIFYRIVTSVFQNAYNEN--CTLNIAKSWKLFETL---GASEAGKKQISDAFHLCNALKNDDD 260
            |...|:|.||:.|   |.::  |...:..:::..:.|   ||.:.    ||..|..|.:|.:..|
Mouse   207 DSYQFFRDVTADF---YGQSPKCAQAVRDAFQQIKDLFLQGAYDT----ISQNFGTCQSLSSPKD 264

  Fly   261 LKKFLDYVEEVYSNLAMVNYPYNSSFLAPLPAYPVRQVCYYLKE-------LHSTDADLLHAMSS 318
            |.:...:....::.|||::|||.:.||.||||.||:..|..|..       |.:. |.|::..|.
Mouse   265 LTQLFGFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCQRLLNEGQRIMGLRAL-AGLVYNSSG 328

  Fly   319 ALAVYTNYTQSAKCLD-ISVNSNADDSGWNIQSCNQMVMPICSNGSETMFRTSSWNFKDYAEKCY 382
            ....|..|.....|.| ....:.:|...|:.|:|.::.:...||....||....::.:...:.|.
Mouse   329 TEPCYDIYRLYQSCADPTGCGTGSDARAWDYQACTEINLTFDSNNVTDMFPEIPFSEELRQQYCL 393

  Fly   383 KNYRLTPKPYDIILRYGGRNLEAATNIIFSNGLLDPWSGGGVLQAPNDKVFVIILPEGAHHLDLR 447
            ..:.:.|:...:...:.|.:|:||:|||||||.||||:|||:....:..|..:.:..||||||||
Mouse   394 DTWGVWPRQDWLQTSFWGGDLKAASNIIFSNGDLDPWAGGGIQSNLSTSVIAVTIQGGAHHLDLR 458

  Fly   448 HSDPADPPSVRDARDKEAAIIARWI 472
            .|:..|||||.:.|..|:.:|..|:
Mouse   459 ASNSEDPPSVVEVRKLESTLIREWV 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2493	NP_001260630.1	Abhydrolase	43..464	CDD:304388	175/438 (40%)
Dpp7	NP_114031.2	Abhydrolase	48..475	CDD:304388	175/439 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2183
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5188
OMA	1	1.010	-	-		QHG55283
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101877
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.670