Protein Alignment CG2493 and PRSS16

DIOPT Version :10

• Sequence 1: NP_610037.1
• Gene: CG2493 / 35316
• FlyBaseID: FBgn0032864
• Length: 475
• Species: Drosophila melanogaster
• Sequence 2: NP_005856.1
• Gene: PRSS16 / 10279
• HGNCID: 9480
• Length: 514
• Species: Homo sapiens
• Alignment Length: 535
• Identity: 130/535 - (24%)
• Similarity: 197/535 - (36%)
• Gaps: 121/535 - (22%)

  Fly    15 LLAVLGILLIAGCDCSQRFKYEIKEFQ-----------------VP--------LDHFSFLINAT 54
            |:::.|  |:|.....:|....|::||                 :|        ||.|:.....:
Human    14 LVSLWG--LLAPASLLRRLGEHIQQFQESSAQGLGLSLGPGAAALPKVGWLEQLLDPFNVSDRRS 76

  Fly    55 FNIRYLYNDS-FVDKSNARTPIFFYTGNEGDIELFAQNTGFLWEQAERQRALVIFAEHRYYGKSL 118
            |..||..||. :|.:..   |||.:.|.||.:...:...|.....|....||||..|||:||.|:
Human    77 FLQRYWVNDQHWVGQDG---PIFLHLGGEGSLGPGSVMRGHPAALAPAWGALVISLEHRFYGLSI 138

  Fly   119 PFGSSTFNTSLPEHLAYFTVEQTLEDYA---MLITFLRN-DRQMPVVAFGGSYGGMLAAWFRMKY 179
            |.|....     ..|.:.:....|.|..   :.::.|.| ....|.:.|||||.|.||||.|:|:
Human   139 PAGGLEM-----AQLRFLSSRLALADVVSARLALSRLFNISSSSPWICFGGSYAGSLAAWARLKF 198

  Fly   180 PHLVNGALAASAP---VLQFPGITDCDIFYRIVTSVFQNAYNENCTLNIAKSWKLFET---LGAS 238
            |||:..::|:|||   ||.|....|.     :..|:...|...:.....|.|....|.   |.:.
Human   199 PHLIFASVASSAPVRAVLDFSEYNDV-----VSRSLMSTAIGGSLECRAAVSVAFAEVERRLRSG 258

  Fly   239 EAGKKQISDAFHLCNALKNDDDLKKFLDYVEEVYSNLAMVNYPYNSSFLAPLPAYPVRQVCYYL- 302
            .|.:..:......|..|...::..:.|..::.:...:..    |:....|||   .|||:|..|
Human   259 GAAQAALRTELSACGPLGRAENQAELLGALQALVGGVVQ----YDGQTGAPL---SVRQLCGLLL 316

  Fly   303 ----KELHSTD-ADLLHAMSSALAVYTNYTQSAKCLDIS-------------VNSNADDSGWNIQ 349
                ...|||. ..|..|:...|     ::...|||..|             ..|...|..|..|
Human   317 GGGGNRSHSTPYCGLRRAVQIVL-----HSLGQKCLSFSRAETVAQLRSTEPQLSGVGDRQWLYQ 376

  Fly   350 SCNQMVMPI-CSNGSETMFRTSSWNFKDYAEKC-YKNYRLTPKPYDIILR--------------- 397
            :|.:....: |.|                 .:| :......|...|:..:
Human   377 TCTEFGFYVTCEN-----------------PRCPFSQLPALPSQLDLCEQVFGLSALSVAQAVAQ 424

  Fly   398 ----YGGRNLEAATNIIFSNGLLDPWSGGGVLQAPNDKVFVIILPEGAHHLDLRHSDPADPPSVR 458
                |||:. ..|..::|.||..|||....|.||.......:::..|:|.||:....|:|.||:|
Human   425 TNSYYGGQT-PGANKVLFVNGDTDPWHVLSVTQALGSSESTLLIRTGSHCLDMAPERPSDSPSLR 488

  Fly   459 DARDKEAAIIARWIQ 473
            ..|......:..|::
Human   489 LGRQNIFQQLQTWLK 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2493	NP_610037.1	alpha/beta hydrolases	43..464	CDD:473884	121/479 (25%)
PRSS16	NP_005856.1	Peptidase_S28	64..494	CDD:310284	120/472 (25%)