Protein Alignment Cdc23 and CDC27

DIOPT Version :10

• Sequence 1: NP_610036.2
• Gene: Cdc23 / 35315
• FlyBaseID: FBgn0032863
• Length: 678
• Species: Drosophila melanogaster
• Sequence 2: NP_001107563.1
• Gene: CDC27 / 996
• HGNCID: 1728
• Length: 830
• Species: Homo sapiens
• Alignment Length: 92
• Identity: 21/92 - (22%)
• Similarity: 30/92 - (32%)
• Gaps: 43/92 - (46%)

  Fly   208 FEYLERDLPYVREPFADKMSDLASRFPELKTLRSCDLLPSSWFSVAWYPIYKIPTGPTLKDLDAC 272
            |.|:.:..||:|:|.|         :|:|:.|              .|..|.:|.        .|
Human   248 FIYIYQYEPYLRDPVA---------YPKLQML--------------MYLFYALPF--------YC 281

  Fly   273 FLTYHSLHTP-----------FQGKIG 288
            ...| :|..|           |.|.||
Human   282 LAAY-ALAFPGCSWLPDWALVFAGAIG 307

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdc23	NP_610036.2	ANAPC8	13..119	CDD:427675
		LapB	255..521	CDD:442196	11/45 (24%)
		TPR repeat	255..278	CDD:276809	5/22 (23%)
		TPR repeat	318..346	CDD:276809
		TPR repeat	351..381	CDD:276809
		TPR repeat	386..414	CDD:276809
		TPR repeat	420..448	CDD:276809
		TPR repeat	454..477	CDD:276809
		TPR repeat	494..522	CDD:276809
CDC27	NP_001107563.1	TPR 1	6..35
		ANAPC3	17..92	CDD:463743
		TPR 2	38..65
		TPR 3	67..99
		TPR 4	115..145
		Spy	454..>677	CDD:443119
		TPR 5	471..501
		TPR 6	505..534
		TPR repeat	507..533	CDD:276809
		TPR 7	539..569
		TPR	567..>737	CDD:440225
		TPR 8	573..604
		TPR repeat	573..601	CDD:276809
		TPR repeat	606..636	CDD:276809
		TPR 9	607..637
		TPR 10	641..673
		TPR repeat	641..669	CDD:276809
		NlpI	<671..810	CDD:443815
		TPR repeat	675..702	CDD:276809
		TPR 11	676..708
		TPR repeat	709..737	CDD:276809
		TPR 12	710..740
		TPR 13	743..774
		TPR repeat	743..771	CDD:276809
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	787..830