DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cdc23 and CDC23

DIOPT Version :9

Sequence 1:NP_001260629.1 Gene:Cdc23 / 35315 FlyBaseID:FBgn0032863 Length:678 Species:Drosophila melanogaster
Sequence 2:NP_004652.2 Gene:CDC23 / 8697 HGNCID:1724 Length:597 Species:Homo sapiens


Alignment Length:600 Identity:273/600 - (45%)
Similarity:375/600 - (62%) Gaps:51/600 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 RELRRGIIECS----KRGLLHSTKWLAEMHHGLADVHIDNEAPDEDRTFSECQLEGIAPEEYSDY 76
            ||:::.::..:    :||||||:||.||:...|..:.:....|....|..:.|       :...|
Human    30 REIKKQLLLIAGLTRERGLLHSSKWSAELAFSLPALPLAELQPPPPITEEDAQ-------DMDAY 87

  Fly    77 FLAKSYYDVREYDRAAHAVRNCESSVPRFLHFYSSYMAREKRRLDSTTDQANLHEPNQMRDLADL 141
            .|||:|:||:|||||||.:..|.|....||:.||.|::.||::.|.|.|.....|..|:::  :.
Human    88 TLAKAYFDVKEYDRAAHFLHGCNSKKAYFLYMYSRYLSGEKKKDDETVDSLGPLEKGQVKN--EA 150

  Fly   142 LATLRMEYGKS----RLDGYGIYLYGVVLKALNLNQAAEQMLVQAIRLVPMLWSAYLELSPLIME 202
            |..||:|..|.    .|||:|:|||||||:.|:|.:.|..:.|:|..::|:.|.|:|||..||.:
Human   151 LRELRVELSKKHQARELDGFGLYLYGVVLRKLDLVKEAIDVFVEATHVLPLHWGAWLELCNLITD 215

  Fly   203 KKKLLSLQLGGHWMRHFFMAHTYLELYLNDDGLKIYEDLQASGFSKSIYLIAQMALVYHNKRDVD 267
            |:.|..|.|...||:.||:||.|.||.|.::.|:.|::|...|||||.|:::|:|:.|||.||:|
Human   216 KEMLKFLSLPDTWMKEFFLAHIYTELQLIEEALQKYQNLIDVGFSKSSYIVSQIAVAYHNIRDID 280

  Fly   268 KAIELYQALLESDPYRLDNVDTYSNLLFVKEMKTEMAQLAHKAVSINKYRPETCCVIGNYYSIRC 332
            ||:.::..|.:.||||::|:||:||||:|:.||:|::.|||....|:|||.|||||||||||:|.
Human   281 KALSIFNELRKQDPYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRS 345

  Fly   333 DHQVAISYFQRALKLNPKYLAAWTLMGHEFMELKNTNAAIQSYRKAVEVNKRDYRAWYGLGQAYE 397
            .|:.|..||||||||||:||.||||||||:||:|||:||||:||.|:|||||||||||||||.||
Human   346 QHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYE 410

  Fly   398 IIKMHYYSLYYFKIAHQLRPYDSRMLVALGETYEKLDKCENAVKCYWKAIDVGDIEGIAMYKLAN 462
            |:||.:|.|||::.||||||.||||||||||.||||::...|.||||:|..|||:|.:|:.|||.
Human   411 ILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRAYAVGDVEKMALVKLAK 475

  Fly   463 LHEKLGDHETAVHCYIMYCEDERAATD-----KQSLYQGFITLANYYEKKGEYERAAYYAYKCLD 522
            |||:|.:.|.|..|||.|.:|..:..:     ::|  ..|..||.||.|...::.|:..|.||..
Human   476 LHEQLTESEQAAQCYIKYIQDIYSCGEIVEHLEES--TAFRYLAQYYFKCKLWDEASTCAQKCCA 538

  Fly   523 SEDRKMEAKALLKTIDWKRNAEGQKKVKTSTAVANADTSSEDEMEWELQDVRVRVPI---TSIAT 584
            ..|.:.|.||||:.|...||                        :.|.....|..|.   .|::.
Human   539 FNDTREEGKALLRQILQLRN------------------------QGETPTTEVPAPFFLPASLSA 579

  Fly   585 TTTSTTTVAAESASS 599
            ..|.|..|:..:.||
Human   580 NNTPTRRVSPLNLSS 594

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cdc23NP_001260629.1 ANAPC8 11..119 CDD:281973 39/106 (37%)
TPR 235..507 CDD:223533 163/276 (59%)
TPR repeat 255..278 CDD:276809 11/22 (50%)
TPR repeat 318..346 CDD:276809 19/27 (70%)
TPR repeat 351..381 CDD:276809 22/29 (76%)
TPR repeat 386..414 CDD:276809 19/27 (70%)
TPR repeat 420..448 CDD:276809 19/27 (70%)
TPR repeat 454..477 CDD:276809 10/22 (45%)
TPR repeat 494..522 CDD:276809 10/27 (37%)
CDC23NP_004652.2 TPR 1 27..63 12/32 (38%)
ANAPC8 45..148 CDD:397937 42/109 (39%)
TPR 2 73..112 17/45 (38%)
TPR 3 114..144 11/29 (38%)
TPR 4 169..200 14/30 (47%)
YciM 214..>491 CDD:225504 167/276 (61%)
TPR 5 229..259 12/29 (41%)
TPR 6 263..293 12/29 (41%)
TPR 7 297..327 14/29 (48%)
TPR 8 331..361 21/29 (72%)
TPR repeat 331..359 CDD:276809 19/27 (70%)
TPR 9 366..395 21/28 (75%)
TPR repeat 367..393 CDD:276809 20/25 (80%)
TPR repeat 398..428 CDD:276809 21/29 (72%)
TPR 10 400..432 23/31 (74%)
TPR 11 433..466 22/32 (69%)
TPR repeat 433..461 CDD:276809 19/27 (70%)
TPR repeat 467..495 CDD:276809 14/27 (52%)
TPR 12 468..500 15/31 (48%)
TPR repeat 501..536 CDD:276809 9/36 (25%)
TPR 13 504..540 11/37 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147298
Domainoid 1 1.000 99 1.000 Domainoid score I7087
eggNOG 1 0.900 - - E1_COG0013
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H3426
Inparanoid 1 1.050 509 1.000 Inparanoid score I1333
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54610
OrthoDB 1 1.010 - - D143997at33208
OrthoFinder 1 1.000 - - FOG0003812
OrthoInspector 1 1.000 - - otm40648
orthoMCL 1 0.900 - - OOG6_102790
Panther 1 1.100 - - LDO PTHR12558
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2062
SonicParanoid 1 1.000 - - X2656
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

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