DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdc23 and aars2

DIOPT Version :9

Sequence 1:	NP_001260629.1	Gene:	Cdc23 / 35315	FlyBaseID:	FBgn0032863	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	XP_001332388.5	Gene:	aars2 / 792787	ZFINID:	ZDB-GENE-041008-213	Length:	1004	Species:	Danio rerio

Alignment Length:	616	Identity:	122/616 - (19%)
Similarity:	212/616 - (34%)	Gaps:	173/616 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LADVHIDNEAPDEDRTFSECQLE-GIAPEEYSDYFLAK-SYYDVREYDRAAHAVRNCESSVPRFL 106
            |..:..:.|:....|...:|.:: |:..|........| |.||...:.....|:..| |..|
Zfish   255 LVFMQYNRESNGSLRALPQCSVDTGMGLERLVTVLQGKRSNYDTDLFTPLLSAIHQC-SKAP--- 315

  Fly   107 HFYSSYMAREKRRLDSTTDQANLHEPNQMRDLADLLATLRMEYGKS---RLDGYGIYLYGVVLKA 168
                :|..|     ....|.|.|  ....|.:||.:.|:.:.....   .:.|..:.|..::.:|
Zfish   316 ----AYQGR-----TGAADVAQL--DMAYRVVADHIRTICVCIADGVYPGMAGAELVLRRILRRA 369

  Fly   169 LNLN----QAAEQMLVQAIRLVP----MLWSAYLELSPLIMEKKKLLSL--QLGGHWM------- 216
            :..:    ||.|..|..   |||    :|..||.||:   .|..:::.|  |...|::
Zfish   370 VRFSTEVLQAPEGALAS---LVPTVAHLLGDAYPELN---TESDRIMDLINQNEAHFLSSLKQGR 428

  Fly   217 -------------RHFFMAHTYLELYLNDDGLKIYEDLQASGFSKSI--YLIAQMALVYHNKRDV 266
                         ..||.|.....||.|            .||...:  .::.:...:. :|:::
Zfish   429 RVIDRTLSNMDENSSFFPASVAWSLYRN------------LGFPLDLIDLMLEEKGKIV-DKKEM 480

  Fly   267 DKAIELYQAL----LESDPYRLDNVDTYSNLLFVKEMKTEMAQLAHKAVSINKYRPETCCVIGN- 326
            ....:.|:.|    .|.:..:||.:|.:|           :|:|..:.|......|:.|..:|:
Zfish   481 KVLEDEYEKLGLQSEEDEGEKLDQLDLHS-----------LAELQRQRVPHTDDSPKYCYSVGSD 534

  Fly   327 --YYSIRCDHQVAISYFQRALKLNPKYLAAWTLMGHEFMELKNTNAAIQSYRKAVEVNKRDYRAW 389
              |....|...|...|...||                      .:...|....||.:::..:.|.
Zfish   535 GQYVFEPCKASVLALYCDGAL----------------------VSEVRQGQHCAVILDQTSFYAE 577

  Fly   390 YGLGQAYEIIKMHYYS-------LYYFKIAHQLRPYDSRMLVALGETYEKLDKCENAVKCYWKAI 447
            .| |||.:   ..|::       |:..|.......|....:.| .||....|:....|...|:
Zfish   578 QG-GQAND---QGYFTKDGLQDVLFPVKCVRLAGGYVVHKVTA-AETLRTGDQVHLHVDEAWR-- 635

  Fly   448 DVGDIEGIAMYKLAN--LHEKLGD--HETAVHCYIMYCEDERAATDKQSLYQGFITLANYYEKKG 508
             :|.:.......:.|  |.|.||.  .:...|     |...|...|..  .:|.:|:
Zfish   636 -LGCMINHTATHVLNFALRELLGPIVSQRGSH-----CSANRLRFDFS--VKGTLTV-------- 684

  Fly   509 EYERAAYYAYKCLDSEDRKMEAKALLKTIDWKRNAEGQ-KKVKTSTAVANADTSSEDEMEWE-LQ 571
                          ||.:|:| :.:|..|  ::||:.. ::|..|:|...|...:.||:..: ::
Zfish   685 --------------SELQKVE-ELVLNII--RQNADVHVEEVPLSSAKQIAGLRTVDELYPDPVR 732

  Fly   572 DVRVRVPITSIATTTTSTTTVAAESASSSSL 602
            .|.|.||::.:         :|:|.|..:|:
Zfish   733 VVSVAVPVSDL---------LASERAEQTSV 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc23	NP_001260629.1	ANAPC8	11..119	CDD:281973	16/76 (21%)
		TPR	235..507	CDD:223533	52/291 (18%)
		TPR repeat	255..278	CDD:276809	3/26 (12%)
		TPR repeat	318..346	CDD:276809	8/30 (27%)
		TPR repeat	351..381	CDD:276809	3/29 (10%)
		TPR repeat	386..414	CDD:276809	8/34 (24%)
		TPR repeat	420..448	CDD:276809	6/27 (22%)
		TPR repeat	454..477	CDD:276809	6/26 (23%)
		TPR repeat	494..522	CDD:276809	2/27 (7%)
aars2	XP_001332388.5	PLN02900	41..993	CDD:215487	122/616 (20%)
		AlaRS_core	44..292	CDD:238360	6/36 (17%)
		tRNA_SAD	565..787	CDD:298782	51/239 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0013
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900