Protein Alignment Cdc23 and AARS2

DIOPT Version :10

• Sequence 1: NP_610036.2
• Gene: Cdc23 / 35315
• FlyBaseID: FBgn0032863
• Length: 678
• Species: Drosophila melanogaster
• Sequence 2: NP_065796.2
• Gene: AARS2 / 57505
• HGNCID: 21022
• Length: 985
• Species: Homo sapiens
• Alignment Length: 266
• Identity: 50/266 - (18%)
• Similarity: 92/266 - (34%)
• Gaps: 65/266 - (24%)

  Fly   163 GVVLKALNLNQAAEQMLVQAIRLVP--MLWSAYLE------LSPLIMEKKKLLSLQLGGHWMRHF 219
            |...|....|.|.|  |:..:..:|  .||.:|.:      |.|.:..:...|||.:....:..|
Human   141 GEYFKEEACNMAWE--LLTQVYGIPEERLWISYFDGDPKAGLDPDLETRDIWLSLGVPASRVLSF 203

  Fly   220 FMAHTYLELYLNDDG-----LKIYEDLQASGFSKSIYLIAQMALVYHNKR-------------DV 266
            .....:.|  :.|.|     .:|:.||.....:..:..:..:..:.||:.             |.
Human   204 GPQENFWE--MGDTGPCGPCTEIHYDLAGGVGAPQLVELWNLVFMQHNREADGSLQPLPQRHVDT 266

  Fly   267 DKAIELYQALLESDPYRLDNVDTYSNLL-----------------FVKEMKTEMAQLAHKAVSIN 314
            ...:|...|:|:......| .|.:|.||                 ...|.:|:   .|::.|: :
Human   267 GMGLERLVAVLQGKHSTYD-TDLFSPLLNAIQQGCRAPPYLGRVGVADEGRTD---TAYRVVA-D 326

  Fly   315 KYRPETCCVIGNYYS--------IRCDHQVAISYFQRALKLNPKYLAAWT-----LMGHEFMELK 366
            ..|..:.|:....:.        :|...:.|:.:....||..|.:|.:..     .:|..:.||:
Human   327 HIRTLSVCISDGIFPGMSGPPLVLRRILRRAVRFSMEILKAPPGFLGSLVPVVVETLGDAYPELQ 391

  Fly   367 NTNAAI 372
            ..:|.|
Human   392 RNSAQI 397

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdc23	NP_610036.2	ANAPC8	13..119	CDD:427675
		LapB	255..521	CDD:442196	28/161 (17%)
		TPR repeat	255..278	CDD:276809	5/35 (14%)
		TPR repeat	318..346	CDD:276809	3/35 (9%)
		TPR repeat	351..381	CDD:276809	6/27 (22%)
		TPR repeat	386..414	CDD:276809
		TPR repeat	420..448	CDD:276809
		TPR repeat	454..477	CDD:276809
		TPR repeat	494..522	CDD:276809
AARS2	NP_065796.2	PLN02900	46..983	CDD:215487	50/266 (19%)