DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdc23 and cdc23

DIOPT Version :9

Sequence 1:	NP_001260629.1	Gene:	Cdc23 / 35315	FlyBaseID:	FBgn0032863	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001016759.1	Gene:	cdc23 / 549513	XenbaseID:	XB-GENE-1015904	Length:	581	Species:	Xenopus tropicalis

Alignment Length:	545	Identity:	265/545 - (48%)
Similarity:	363/545 - (66%)	Gaps:	28/545 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LPDVKRELRRGIIECSKRGLLHSTKWLAEMHHGLADVHIDNEAP------DEDRTFSECQLEGIA 69
            |.::|::|......|.:|||:||.||.:|:...|..:.: ||.|      :||
Frog    11 LKEIKKQLLSVTWLCRERGLMHSVKWASELAFSLESIPL-NELPSTPALTEED------------ 62

  Fly    70 PEEYSDYFLAKSYYDVREYDRAAHAVRNCESSVPRFLHFYSSYMAREKRRLDSTTDQANLHEPNQ 134
            .::...|.|||||:|::||||||:.:|.|:|....||:.||.|::.||::.|.|.|.....|..|
Frog    63 AQDLDAYTLAKSYFDLKEYDRAAYFLRGCKSQKAYFLYMYSRYLSGEKKKDDETVDSLGPLEKGQ 127

  Fly   135 MRDLADLLATLRMEYGKS----RLDGYGIYLYGVVLKALNLNQAAEQMLVQAIRLVPMLWSAYLE 195
            :::  :.|..||:|..|.    .|||:|:|||||||:.|:|.:.|..:.|:|..::|:.|..:||
Frog   128 VKN--EALRELRVELSKKHKARELDGFGLYLYGVVLRKLDLAKEALDVFVEATHVLPLHWGTWLE 190

  Fly   196 LSPLIMEKKKLLSLQLGGHWMRHFFMAHTYLELYLNDDGLKIYEDLQASGFSKSIYLIAQMALVY 260
            |..||.:|:.|..|.|...|::.||:||.|.||.|.::.|:.|:.|..:|||||.|:|:|:|:.|
Frog   191 LCNLITDKEMLKFLSLPESWIKEFFLAHIYTELQLIEEALQKYQSLIDAGFSKSTYIISQIAVAY 255

  Fly   261 HNKRDVDKAIELYQALLESDPYRLDNVDTYSNLLFVKEMKTEMAQLAHKAVSINKYRPETCCVIG 325
            ||.||:|||:.::..|.:.||||::|:||:||||:|:.:|.|::.|||....|:|||.|||||||
Frog   256 HNIRDIDKALSIFNELRKQDPYRIENMDTFSNLLYVRGLKPELSYLAHNLCDIDKYRVETCCVIG 320

  Fly   326 NYYSIRCDHQVAISYFQRALKLNPKYLAAWTLMGHEFMELKNTNAAIQSYRKAVEVNKRDYRAWY 390
            ||||:|..|:.|..||||||||||:||.||||||||:||:|||:||||:||.|:|||||||||||
Frog   321 NYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWY 385

  Fly   391 GLGQAYEIIKMHYYSLYYFKIAHQLRPYDSRMLVALGETYEKLDKCENAVKCYWKAIDVGDIEGI 455
            ||||.|||:||.:|.|||::.||||||.||||||||||.||||::...|.||||:|..|||:|.:
Frog   386 GLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRAYAVGDVEKM 450

  Fly   456 AMYKLANLHEKLGDHETAVHCYIMYCEDERAA---TDKQSLYQGFITLANYYEKKGEYERAAYYA 517
            |:.|||.|||:|.:.|.|..|||.|.:|..:.   .:.|.|...|..||.||.|...::.|:..|
Frog   451 ALVKLAKLHEQLNESEQAAQCYIKYIQDIYSCGEIVEHQELSTAFRYLAQYYFKCKLWDEASACA 515

  Fly   518 YKCLDSEDRKMEAKALLKTIDWKRN 542
            .||.:..|.:.|.||||:.|...||
Frog   516 QKCFNFNDTREEGKALLRQILQLRN 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc23	NP_001260629.1	ANAPC8	11..119	CDD:281973	41/113 (36%)
		TPR	235..507	CDD:223533	164/274 (60%)
		TPR repeat	255..278	CDD:276809	11/22 (50%)
		TPR repeat	318..346	CDD:276809	19/27 (70%)
		TPR repeat	351..381	CDD:276809	22/29 (76%)
		TPR repeat	386..414	CDD:276809	19/27 (70%)
		TPR repeat	420..448	CDD:276809	19/27 (70%)
		TPR repeat	454..477	CDD:276809	10/22 (45%)
		TPR repeat	494..522	CDD:276809	10/27 (37%)
cdc23	NP_001016759.1	ANAPC8	13..130	CDD:367783	45/129 (35%)
		YciM	196..>473	CDD:225504	166/276 (60%)
		TPR repeat	313..341	CDD:276809	19/27 (70%)
		TPR repeat	349..375	CDD:276809	20/25 (80%)
		TPR repeat	380..410	CDD:276809	21/29 (72%)
		TPR repeat	415..443	CDD:276809	19/27 (70%)
		TPR repeat	449..477	CDD:276809	14/27 (52%)
		TPR repeat	483..518	CDD:276809	10/34 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I7062
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H3426
Inparanoid	1	1.050	518	1.000	Inparanoid score	I1254
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143997at33208
OrthoFinder	1	1.000	-	-		FOG0003812
OrthoInspector	1	1.000	-	-		otm47825
Panther	1	1.100	-	-	LDO	PTHR12558
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2062
SonicParanoid	1	1.000	-	-		X2656
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.190