DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdc23 and Cdc23

DIOPT Version :9

Sequence 1:	NP_001260629.1	Gene:	Cdc23 / 35315	FlyBaseID:	FBgn0032863	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_848124.1	Gene:	Cdc23 / 52563	MGIID:	1098815	Length:	597	Species:	Mus musculus

Alignment Length:	608	Identity:	278/608 - (45%)
Similarity:	376/608 - (61%)	Gaps:	50/608 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LPDVKRELR--RGIIECSKRGLLHSTKWLAEMHHGLADVHIDNEAPDEDRTFSECQLEGIAPEEY 73
            |.::|::|.  .|:..  :||||||:||.||:...|..:.:....|....|..:.|       :.
Mouse    29 LQEIKKQLLLIAGLTR--ERGLLHSSKWSAELAFSLPALPLSELQPPPPLTEEDAQ-------DV 84

  Fly    74 SDYFLAKSYYDVREYDRAAHAVRNCESSVPRFLHFYSSYMAREKRRLDSTTDQANLHEPNQMRDL 138
            ..|.|||:|:||:|||||||.:..|.|....||:.||.|::.||::.|.|.|.....|..|:::
Mouse    85 DAYTLAKAYFDVKEYDRAAHFLHGCNSKKAYFLYMYSRYLSGEKKKDDETVDSLGPLEKGQVKN- 148

  Fly   139 ADLLATLRMEYGKSR----LDGYGIYLYGVVLKALNLNQAAEQMLVQAIRLVPMLWSAYLELSPL 199
             :.|..||:|..:..    |||:|:|||||||:.|:|.:.|..:.|:|..::|:.|.|:|||..|
Mouse   149 -EALRELRVELSRKHQARGLDGFGLYLYGVVLRKLDLVKEAIDVFVEATHVLPLHWGAWLELCNL 212

  Fly   200 IMEKKKLLSLQLGGHWMRHFFMAHTYLELYLNDDGLKIYEDLQASGFSKSIYLIAQMALVYHNKR 264
            |.:|:.|..|.|...||:.||:||.|.||.|.::.|:.|:.|...|||||.|:::|:|:.|||.|
Mouse   213 ITDKEMLKFLSLPDTWMKEFFLAHIYTELQLIEEALQKYQHLIDVGFSKSSYIVSQIAVAYHNIR 277

  Fly   265 DVDKAIELYQALLESDPYRLDNVDTYSNLLFVKEMKTEMAQLAHKAVSINKYRPETCCVIGNYYS 329
            |:|||:.::..|.:.||||::|:||:||||:|:.||:|::.|||....|:|||.|||||||||||
Mouse   278 DIDKALSIFNELRKQDPYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYS 342

  Fly   330 IRCDHQVAISYFQRALKLNPKYLAAWTLMGHEFMELKNTNAAIQSYRKAVEVNKRDYRAWYGLGQ 394
            :|..|:.|..||||||||||:||.||||||||:||:|||:||||:||.|:|||||||||||||||
Mouse   343 LRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQ 407

  Fly   395 AYEIIKMHYYSLYYFKIAHQLRPYDSRMLVALGETYEKLDKCENAVKCYWKAIDVGDIEGIAMYK 459
            .|||:||.:|.|||::.||||||.||||||||||.||||::...|.||||:|..|||:|.:|:.|
Mouse   408 TYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRAYAVGDVEKMALVK 472

  Fly   460 LANLHEKLGDHETAVHCYIMYCED-----ERAATDKQSLYQGFITLANYYEKKGEYERAAYYAYK 519
            ||.|||:|.:.|.|..|||.|.:|     |.....::|  ..|..||.||.|...::.|:..|.|
Mouse   473 LAKLHEQLTESEQAAQCYIKYIQDIYSCGETVEHLEES--TAFRYLAQYYFKCKLWDEASTCAQK 535

  Fly   520 CLDSEDRKMEAKALLKTIDWKRNAEGQKKVKTSTAVANADTSSEDEMEWELQDVRVRVPITSIAT 584
            |....|.:.|.||||:.|...||   |.:..||      ||                 |.|....
Mouse   536 CCAFNDTREEGKALLRQILQLRN---QGETPTS------DT-----------------PGTFFLP 574

  Fly   585 TTTSTTTVAAESASSSSLISLRP 607
            .:.|.........|..:|.|:.|
Mouse   575 ASLSANNTPTRRVSPLNLSSVTP 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc23	NP_001260629.1	ANAPC8	11..119	CDD:281973	41/109 (38%)
		TPR	235..507	CDD:223533	164/276 (59%)
		TPR repeat	255..278	CDD:276809	11/22 (50%)
		TPR repeat	318..346	CDD:276809	19/27 (70%)
		TPR repeat	351..381	CDD:276809	22/29 (76%)
		TPR repeat	386..414	CDD:276809	19/27 (70%)
		TPR repeat	420..448	CDD:276809	19/27 (70%)
		TPR repeat	454..477	CDD:276809	10/22 (45%)
		TPR repeat	494..522	CDD:276809	10/27 (37%)
Cdc23	NP_848124.1	TPR 1	27..63		14/35 (40%)
		ANAPC8	28..154	CDD:281973	46/126 (37%)
		TPR 2	73..112		15/38 (39%)
		TPR 3	114..144		11/29 (38%)
		TPR 4	169..200		15/34 (44%)
		TPR repeat	172..197	CDD:276809	14/24 (58%)
		TPR repeat	202..257	CDD:276809	23/54 (43%)
		TPR	<212..399	CDD:223533	107/186 (58%)
		TPR 5	229..259		13/29 (45%)
		TPR 6	263..293		16/29 (55%)
		TPR repeat	263..291	CDD:276809	16/27 (59%)
		TPR 7	297..327		17/29 (59%)
		TPR_1	331..364	CDD:278916	23/32 (72%)
		TPR 8	331..361		20/29 (69%)
		TPR repeat	331..359	CDD:276809	18/27 (67%)
		TPR 9	366..395		22/28 (79%)
		TPR_11	367..430	CDD:290150	47/62 (76%)
		TPR_1	367..398	CDD:278916	23/30 (77%)
		TPR repeat	367..393	CDD:276809	20/25 (80%)
		TPR repeat	398..428	CDD:276809	24/29 (83%)
		TPR 10	400..432		23/31 (74%)
		TPR 11	433..466		23/32 (72%)
		TPR repeat	433..461	CDD:276809	19/27 (70%)
		TPR repeat	467..495	CDD:276809	14/27 (52%)
		TPR 12	468..500		17/31 (55%)
		TPR repeat	501..536	CDD:276809	10/39 (26%)
		TPR 13	504..540		11/35 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837228
Domainoid	1	1.000	98	1.000	Domainoid score	I7174
eggNOG	1	0.900	-	-		E1_COG0013
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3426
Inparanoid	1	1.050	508	1.000	Inparanoid score	I1321
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54610
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003812
OrthoInspector	1	1.000	-	-		otm42721
orthoMCL	1	0.900	-	-		OOG6_102790
Panther	1	1.100	-	-	LDO	PTHR12558
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2062
SonicParanoid	1	1.000	-	-		X2656
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790