DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdc23 and cdc23

DIOPT Version :9

Sequence 1:	NP_001260629.1	Gene:	Cdc23 / 35315	FlyBaseID:	FBgn0032863	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_957227.1	Gene:	cdc23 / 393907	ZFINID:	ZDB-GENE-040426-866	Length:	579	Species:	Danio rerio

Alignment Length:	540	Identity:	263/540 - (48%)
Similarity:	356/540 - (65%)	Gaps:	28/540 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LPDVKRELRRGIIECSKRGLLHSTKWLAEMHHGLADVHIDNEAPDEDRTFSECQ-LEGIAPEEYS 74
            |..:|::|...|.:|.:|||:||.||.:|:...|..:.::...|..:.|..:.| |:.:.
Zfish    12 LVQIKKQLISIIAQCKERGLVHSVKWASELAFSLDPLPLNEIPPPPELTEEDAQDLDALC----- 71

  Fly    75 DYFLAKSYYDVREYDRAAHAVRNCESSVPRFLHFYSSYMAREKRRLDSTTDQANLHEPNQMRDLA 139
               |||||:|::||||||:.:|.|.|....||:.||.|::.||::.|.|.|.....|..|:|:
Zfish    72 ---LAKSYFDLKEYDRAAYFLRGCRSQKAYFLYMYSRYLSGEKKKDDETVDSLGPLEKGQVRN-- 131

  Fly   140 DLLATLRMEYGK----SRLDGYGIYLYGVVLKALNLNQAAEQMLVQAIRLVPMLWSAYLELSPLI 200
            :.|..||:|..|    ..|||:.:|||||||:.|:|.:.|.::.|.|...:|:.|.::|||..||
Zfish   132 EALRELRVELSKKHSAGELDGFALYLYGVVLRKLDLLKEAVEIFVAATHALPLHWGSWLELCNLI 196

  Fly   201 MEKKKLLSLQLGGHWMRHFFMAHTYLELYLNDDGLKIYEDLQASGFSKSIYLIAQMALVYHNKRD 265
            ...:.|.||.|...|:|.|||||.|.||.:..:.|:.|:.|..:||:||.|:|:|:|:.|||.||
Zfish   197 TNIEMLKSLSLPDCWVRDFFMAHMYTELQMIKEALQKYQSLMEAGFAKSSYIISQIAVAYHNIRD 261

  Fly   266 VDKAIELYQALLESDPYRLDNVDTYSNLLFVKEMKTEMAQLAHKAVSINKYRPETCCVIGNYYSI 330
            :|:|:.|:..|.|.||:|::|:||:||||:|:.||.|::.|||..|.|:|||.|||||||||||:
Zfish   262 IDQALYLFNELREQDPFRIENMDTFSNLLYVRSMKPELSYLAHNLVEIDKYRVETCCVIGNYYSL 326

  Fly   331 RCDHQVAISYFQRALKLNPKYLAAWTLMGHEFMELKNTNAAIQSYRKAVEVNKRDYRAWYGLGQA 395
            |..|:.|..||||||||||:.|.||||||||:||:|||:||||:||.|:|||||||||||||||.
Zfish   327 RSQHEKAALYFQRALKLNPRCLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQT 391

  Fly   396 YEIIKMHYYSLYYFKIAHQLRPYDSRMLVALGETYEKLDKCENAVKCYWKAIDVGDIEGIAMYKL 460
            |||:||.:|||||::.||||||.||||||||||.||||.:...|.||||:|..|||:|.:|:.||
Zfish   392 YEILKMPFYSLYYYRKAHQLRPNDSRMLVALGECYEKLSQQLEAKKCYWRAYSVGDVERMALLKL 456

  Fly   461 ANLHEKLGDHETAVHCYIMYCED--------ERAATDKQSLYQGFITLANYYEKKGEYERAAYYA 517
            |.|||:|.:.:.|..|||:|.:|        |.|.......|     |..||.|...|:.|:..|
Zfish   457 AKLHEQLNESDDAAQCYIIYIQDIFSCGEQLEHAEVSTALRY-----LGQYYFKNKLYDEASLCA 516

  Fly   518 YKCLDSEDRKMEAKALLKTI 537
            .:|.|..|.:.|.||||:.|
Zfish   517 QRCCDYNDAREEGKALLRQI 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc23	NP_001260629.1	ANAPC8	11..119	CDD:281973	40/108 (37%)
		TPR	235..507	CDD:223533	163/279 (58%)
		TPR repeat	255..278	CDD:276809	11/22 (50%)
		TPR repeat	318..346	CDD:276809	19/27 (70%)
		TPR repeat	351..381	CDD:276809	21/29 (72%)
		TPR repeat	386..414	CDD:276809	20/27 (74%)
		TPR repeat	420..448	CDD:276809	19/27 (70%)
		TPR repeat	454..477	CDD:276809	9/22 (41%)
		TPR repeat	494..522	CDD:276809	9/27 (33%)
cdc23	NP_957227.1	ANAPC8	11..137	CDD:281973	47/134 (35%)
		TPR repeat	314..342	CDD:276809	19/27 (70%)
		TPR repeat	347..377	CDD:276809	21/29 (72%)
		TPR_11	350..413	CDD:290150	49/62 (79%)
		TPR_1	350..381	CDD:278916	24/30 (80%)
		TPR repeat	382..410	CDD:276809	20/27 (74%)
		TPR repeat	416..444	CDD:276809	19/27 (70%)
		TPR repeat	450..473	CDD:276809	9/22 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580822
Domainoid	1	1.000	94	1.000	Domainoid score	I7437
eggNOG	1	0.900	-	-		E1_COG0013
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3426
Inparanoid	1	1.050	510	1.000	Inparanoid score	I1282
OMA	1	1.010	-	-		QHG54610
OrthoDB	1	1.010	-	-		D143997at33208
OrthoFinder	1	1.000	-	-		FOG0003812
OrthoInspector	1	1.000	-	-		otm26303
orthoMCL	1	0.900	-	-		OOG6_102790
Panther	1	1.100	-	-	LDO	PTHR12558
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2062
SonicParanoid	1	1.000	-	-		X2656
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800