DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdc23 and Cdc27

DIOPT Version :9

Sequence 1:	NP_001260629.1	Gene:	Cdc23 / 35315	FlyBaseID:	FBgn0032863	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001261503.1	Gene:	Cdc27 / 38798	FlyBaseID:	FBgn0012058	Length:	900	Species:	Drosophila melanogaster

Alignment Length:	266	Identity:	66/266 - (24%)
Similarity:	136/266 - (51%)	Gaps:	46/266 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 SIYLIAQMALVYHNKRDVDKAIELYQALLESDPYRLDNVDTYSNLLFVKEMKTEMAQLAHKAVSI 313
            |.::.:.:.|..:..|:.:.|:.:::.:.:::|.|||.::.||:.|:..:.:.|::.||...::.
  Fly   576 SSWVQSLIGLARYEMREYEAAVAIFETIHKTEPCRLDYMEIYSSSLWHLQREVELSALAQDLINQ 640

  Fly   314 NKYRPETCCVIGNYYSIRCDHQVAISYFQRALKLNPKYLAAWTLMGHEFMELKNTNAAIQSYRKA 378
            :|..|.|.||.||.:|::.:|:.||.:|:||::::|.::.::||:|||.:..:..:.|:..:|.|
  Fly   641 DKTSPVTWCVSGNCFSLQKEHETAIKFFKRAVQVDPDFVYSYTLLGHELVLTEEFDKAMDYFRAA 705

  Fly   379 VEVNKRDYRAWYGLG------QAYEIIKMHYYSLYYFKIAHQLRPYDSRMLVAL----------- 426
            |..:.|.|.||||:|      :.||:.::||..      |.::.|.:|.:||.:
  Fly   706 VVRDPRHYNAWYGIGTIYSKQEKYELAEIHYVK------ALKINPQNSVILVHIGAMQFYMKKKD 764

  Fly   427 -----------------------GETYEKLDKCENAVKCYWKAIDVGDIEGIAMYKLANLHEKLG 468
                                   |..|..|.|.:.|::...:..:|...|.:..|.:..:|:.||
  Fly   765 LSLQTLNTAATLDPKNPLTRFHRGSIYFSLGKYQEALRELEELKEVVPKESVVFYLIGKIHKTLG 829

  Fly   469 DHETAV 474
            :.:.|:
  Fly   830 NMDLAL 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc23	NP_001260629.1	ANAPC8	11..119	CDD:281973
		TPR	235..507	CDD:223533	66/266 (25%)
		TPR repeat	255..278	CDD:276809	3/22 (14%)
		TPR repeat	318..346	CDD:276809	13/27 (48%)
		TPR repeat	351..381	CDD:276809	9/29 (31%)
		TPR repeat	386..414	CDD:276809	11/33 (33%)
		TPR repeat	420..448	CDD:276809	8/61 (13%)
		TPR repeat	454..477	CDD:276809	5/21 (24%)
		TPR repeat	494..522	CDD:276809
Cdc27	NP_001261503.1	ANAPC3	16..94	CDD:289650
		TPR_11	67..145	CDD:290150
		TPR repeat	68..104	CDD:276809
		TPR repeat	109..143	CDD:276809
		TPR_12	539..601	CDD:290160	4/24 (17%)
		TPR repeat	582..605	CDD:276809	3/22 (14%)
		TPR	590..850	CDD:223533	64/252 (25%)
		TPR_1	645..678	CDD:278916	14/32 (44%)
		TPR repeat	678..708	CDD:276809	9/29 (31%)
		TPR_1	713..746	CDD:278916	12/38 (32%)
		TPR repeat	713..741	CDD:276809	11/33 (33%)
		TPR repeat	747..773	CDD:276809	3/25 (12%)
		TPR repeat	781..809	CDD:276809	5/27 (19%)
		TPR repeat	815..838	CDD:276809	5/21 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449294
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12558
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940