DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdc23 and aars1

DIOPT Version :9

Sequence 1:	NP_001260629.1	Gene:	Cdc23 / 35315	FlyBaseID:	FBgn0032863	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001037775.1	Gene:	aars1 / 324940	ZFINID:	ZDB-GENE-030131-3663	Length:	991	Species:	Danio rerio

Alignment Length:	827	Identity:	149/827 - (18%)
Similarity:	245/827 - (29%)	Gaps:	321/827 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 EAPDEDRTFSECQLEGIAPEEYSDYFLAKSYYDVREYDRAAHAVRNCESSVP---RFLHFYSSYM 113
            :|...|.:.:..|:.    |::.|:|           .|..|...:..:::|   ..|.|.::.|
Zfish    22 KATSMDSSLTAAQIR----EKFIDFF-----------RRHEHQYVHSSATIPLDDPTLLFANAGM 71

  Fly   114 AREKRRLDSTTDQANLHEPNQMRDLADLLATLRM--------EYGKSRLDGY--------GIYLY 162
            .:.|....:|.|.:  |...::|..|:....:|.        :.||   |.|        |.:.:
Zfish    72 NQFKPIFLNTIDPS--HPMARLRRAANTQKCIRAGGKHNDLDDVGK---DVYHHTFFEMLGSWSF 131

  Fly   163 GVVLKALNLNQAAEQMLVQAIRLVPMLWSAYLELSPLIMEKKKLLSLQLGGHWMRHFFMAHTYLE 227
            |...|.|....|.| :|.|...:            |:    ::|.....|||
Zfish   132 GDYFKHLACKMALE-LLTQEFGI------------PI----ERLYVTYFGGH------------- 166

  Fly   228 LYLNDDGL-------KIYEDLQASGFSKSIYLIAQM----------------ALVYHNK---RDV 266
               .|.||       :|:.||   |..:|..|...|                :.:::::   ||.
Zfish   167 ---ADAGLEPDLECKQIWLDL---GMEESRILPGSMKDNFWEMGDTGPCGPCSEIHYDRIGGRDA 225

  Fly   267 DKAIELYQALLESDPYRLDNVDTYSNLLFV---KEMKTEMAQLAHKAVSINKYRPETCCVIGNYY 328
            ...:.:      .||    ||....||:|:   :|.:|.:..|..|::...........|:.|..
Zfish   226 AHLVNM------DDP----NVLEIWNLVFIQFNRESETVLKPLPKKSIDTGMGLERLVSVLQNKM 280

  Fly   329 SIRCDHQVAISYFQRALKLNPKYLAAWTLMGHEFMELKNTNAAIQSYRKAVEVNKRDYRAWYGLG 393
            | ..|..:.:.||: |::                   |.|.|  ::|...|.....|     |:.
Zfish   281 S-NYDTDLFVPYFE-AIQ-------------------KGTGA--RAYTGKVGAEDTD-----GID 317

  Fly   394 QAYEIIKMHYYSL----------------YYF-KIAHQLRPYDSRMLVA---------------L 426
            .||.::..|..::                |.. :|..:...|....|.|               |
Zfish   318 MAYRVLADHARTITIALSDGGRPDNTGRGYVLRRILRRAVRYSHEKLGAQRGFFASLVDVVVKSL 382

  Fly   427 GETYEKLDKCENAVK-------------------------------------CYWKAID------ 448
            |:.:.:|.|..:.||                                     ..|...|
Zfish   383 GDAFPELRKDPDMVKDIINEEEAQFLKTLSRGRRILDRKIQSLGESTTIPGDTAWLLYDTYGFPL 447

  Fly   449 -----VGDIEGIAMYKLANLHEK-----------LGDHETAVHCYI-MYCEDER-----AATDKQ 491
                 :.:..|:.:..||...||           .||.:   |..: :|..||.     ||||..
Zfish   448 DLTALIAEERGMGVDLLAFEEEKKAAQLKSQGKGSGDED---HIMLDIYAIDELRNKGVAATDDS 509

  Fly   492 SLYQGFITLANYY--EKKGEYE------------RAAYYAYKCLDSEDRKMEAKALLKTIDWKRN 542
            ..|:        |  :..|.||            |...:..:.:..:    |...||....:...
Zfish   510 PKYK--------YTSDDNGNYEFEQAVGTVLALRRERMFVDEVITGQ----ECGVLLDKTSFYAE 562

  Fly   543 AEGQKKVKTSTAVANADTSSEDEMEWELQDVRV-----------------------------RVP 578
            ..||.  .....:...:.|:||.||:.:::.:|                             |.|
Zfish   563 QGGQS--FDEGYMLRENDSAEDRMEFTVKNTQVRGGYVLHIGTVYGTLKVGDRLTLHVDEARRRP 625

  Fly   579 ITSIATTT----TSTTTVAAESASSSSLIS---LRPDRNLIQGMRRSQSSRT------------- 623
            |.|..|.|    ....:|..|:....||::   ||.|......|...:..||
Zfish   626 IMSNHTATHILNYGLRSVLGEADQRGSLVAPDRLRFDFTAKGAMSTDEVRRTEEIAAAMIADAKG 690

  Fly   624 --SLTAPASGTTTTPSATAVTMSTEETPGTSGGPSNPPEQAPSDDNS 668
              :|.||.:.........||...|...|........|.|:..:|.||
Zfish   691 VYALDAPLAAAKAIQGLRAVFDETYPDPVRVVSIGVPVEELLADPNS 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc23	NP_001260629.1	ANAPC8	11..119	CDD:281973	13/69 (19%)
		TPR	235..507	CDD:223533	68/399 (17%)
		TPR repeat	255..278	CDD:276809	3/41 (7%)
		TPR repeat	318..346	CDD:276809	7/27 (26%)
		TPR repeat	351..381	CDD:276809	5/29 (17%)
		TPR repeat	386..414	CDD:276809	6/44 (14%)
		TPR repeat	420..448	CDD:276809	9/79 (11%)
		TPR repeat	454..477	CDD:276809	8/33 (24%)
		TPR repeat	494..522	CDD:276809	6/41 (15%)
aars1	NP_001037775.1	PLN02900	31..984	CDD:215487	147/818 (18%)
		AlaRS_core	32..279	CDD:238360	58/312 (19%)
		tRNA_SAD	719..777	CDD:285247	5/19 (26%)
		DHHA1	911..982	CDD:280440
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0013
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900