DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdc23 and Aars2

DIOPT Version :9

Sequence 1:	NP_001260629.1	Gene:	Cdc23 / 35315	FlyBaseID:	FBgn0032863	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	XP_006244575.1	Gene:	Aars2 / 301254	RGDID:	1310617	Length:	1057	Species:	Rattus norvegicus

Alignment Length:	647	Identity:	132/647 - (20%)
Similarity:	232/647 - (35%)	Gaps:	197/647 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 HGLADVHIDNEAPDEDRTFSECQLEGIAPEEYSDYFLAK-SYYDVREYDRAAHAV-RNCESSVPR 104
            |.|...|:|.               |:..|........| |.||...:.....|: ::|.  ||.
  Rat   252 HLLPQQHVDT---------------GMGLERLVAVLQGKHSTYDTDLFSPLLDAIHQSCR--VPP 299

  Fly   105 FLHFYSSYM-AREKRRLDSTTDQANLHEPNQMRDLADLLATLRMEYGKSRLDGYGIYLYGVVLKA 168
                ||..: |.::.|:|:.           .|.:||.:.||.:    ...||....:.|..|..
  Rat   300 ----YSGRVGAADEGRIDTA-----------YRVVADHIRTLSV----CIADGVSPGMSGAPLVL 345

  Fly   169 LNLNQAAEQMLVQAIR--------LVPM----LWSAYLEL-------SPLIMEKKK--LLSLQLG 212
            ..:.:.|.:...:.::        |||:    |.:||.||       :.|:.|.:.  |.|||.|
  Rat   346 RRILRRAVRYSTEVLQAPPGFLGNLVPVVVATLGAAYPELQKNSVKIANLVSEDEAAFLASLQRG 410

  Fly   213 GHWMRHFFMAHTYLELYLNDDGLKIY--EDLQASGFSKSIYLIAQMALVYHNKRDVDKAIELYQA 275
            ..               :.|..:|..  .||..:..:.|:.|...:.:          .::|.|.
  Rat   411 RR---------------IIDRTVKRLGPSDLFPAEVAWSLSLSGNLGI----------PLDLVQL 450

  Fly   276 LLESDPYRLDNVDTYSNLLFVKEMKTEMAQLAHKAVSINKYRPETCCVIGNYYSIRCDHQVAI-- 338
            :||....:||...       ::::..:.||  |:|......:.|..|:  :.:::...|:..|
  Rat   451 MLEEKGVKLDTAG-------LEQLAQKEAQ--HRAQQAEAAQEEGLCL--DVHALEELHRQGIPT 504

  Fly   339 ----SYFQRALKLNPKYLAAWTLMGHEFMEL-KNTNAAIQS----YRKAVEVNKRDYRAWYGLGQ 394
                ..:..:|:.|..|  .:.|...:.::| ..|..|:.|    .|..:.:::.::.|..| ||
  Rat   505 TDDSPKYNYSLRPNGDY--EFGLCEAQVLQLYSETGTAVASVGEGQRCGLLLDRTNFYAEQG-GQ 566

  Fly   395 AYEIIKMHYYSLYYFKIAHQLRPYDSRMLVALGETYEKLDKCENAVKCYWKAIDVGDIEGIAMYK 459
            |.:                  |.|    |:..|: .:.|.....|..|      .|.|
  Rat   567 ASD------------------RGY----LIRTGQ-QDVLFPVARAQVC------GGFI------- 595

  Fly   460 LANLHE-------KLGDHETAVHCYI-----MYCEDERAATD--KQSLYQGFITLANYYEKKGEY 510
               |||       ::||.   |..|:     |.|..:..||.  ..:|.|   ||....|::|.:
  Rat   596 ---LHEAMAPECLQVGDR---VQLYVDKAWRMGCMVKHTATHLLNWALRQ---TLGPTTEQRGSH 651

  Fly   511 ---ERAAYYAYKCLDSEDRKMEAKALLKTID-WKRNAEGQKKVKTSTAVANADTS------SEDE 565
               ||..:      |...:.......|:|:: :.:.|.||.|......|..|.|:      |.||
  Rat   652 LNPERLRF------DVATQTPLTTEQLRTVESYVQEAVGQDKPVYMEEVPLAHTARIPGLRSLDE 710

  Fly   566 MEWE-LQDVRVRVPIT-SIATTTTSTTTVAAESASSSSLIS--------LRPDRNLIQGMRR 617
            :..: ::.|.|.||:. ::|..:.:....:.|....:.|:|        :..||.|::|:.|
  Rat   711 VYPDPVRVVSVGVPVAQALAPASQAALQTSVELCCGTHLLSTGAVGDLVIIGDRQLVKGITR 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc23	NP_001260629.1	ANAPC8	11..119	CDD:281973	17/79 (22%)
		TPR	235..507	CDD:223533	58/298 (19%)
		TPR repeat	255..278	CDD:276809	2/22 (9%)
		TPR repeat	318..346	CDD:276809	4/33 (12%)
		TPR repeat	351..381	CDD:276809	7/34 (21%)
		TPR repeat	386..414	CDD:276809	5/27 (19%)
		TPR repeat	420..448	CDD:276809	5/27 (19%)
		TPR repeat	454..477	CDD:276809	6/29 (21%)
		TPR repeat	494..522	CDD:276809	7/30 (23%)
Aars2	XP_006244575.1	PLN02900	34..1055	CDD:215487	132/647 (20%)
		AlaRS_core	37..275	CDD:238360	6/37 (16%)
		tRNA_SAD	549..>651	CDD:298782	32/147 (22%)
		tRNA_SAD	<740..773	CDD:197931	8/33 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0013
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900