Protein Alignment Cdc23 and Cdc23

DIOPT Version :10

• Sequence 1: NP_610036.2
• Gene: Cdc23 / 35315
• FlyBaseID: FBgn0032863
• Length: 678
• Species: Drosophila melanogaster
• Sequence 2: NP_001094129.1
• Gene: Cdc23 / 291689
• RGDID: 1304819
• Length: 597
• Species: Rattus norvegicus
• Alignment Length: 605
• Identity: 276/605 - (45%)
• Similarity: 375/605 - (61%)
• Gaps: 50/605 - (8%)

  Fly    16 RELRRGIIECS----KRGLLHSTKWLAEMHHGLADVHIDNEAPDEDRTFSECQLEGIAPEEYSDY 76
            ||:::.::..:    :||||||:||.||:...|..:.:....|....|..:.|       :...|
  Rat    30 REIKKQLLLIAGLTRERGLLHSSKWSAELAFSLPALPLSELQPPPPLTEEDAQ-------DVDAY 87

  Fly    77 FLAKSYYDVREYDRAAHAVRNCESSVPRFLHFYSSYMAREKRRLDSTTDQANLHEPNQMRDLADL 141
            .|||:|:||:|||||||.:..|.|....||:.||.|::.||::.|.|.|.....|..|:::  :.
  Rat    88 TLAKAYFDVKEYDRAAHFLHGCNSKKAYFLYMYSRYLSGEKKKDDETVDSLGPLEKGQVKN--EA 150

  Fly   142 LATLRMEYGKSR----LDGYGIYLYGVVLKALNLNQAAEQMLVQAIRLVPMLWSAYLELSPLIME 202
            |..||:|..:..    |||:|:|||||||:.|:|.:.|..:.|:|..::|:.|.|:|||..||.:
  Rat   151 LRELRVELSRKHQARGLDGFGLYLYGVVLRKLDLVKEAIDVFVEATHVLPLHWGAWLELCNLITD 215

  Fly   203 KKKLLSLQLGGHWMRHFFMAHTYLELYLNDDGLKIYEDLQASGFSKSIYLIAQMALVYHNKRDVD 267
            |:.|..|.|...||:.||:||.|.||.|.::.|:.|:.|...|||||.|:::|:|:.|||.||:|
  Rat   216 KEMLKFLSLPDTWMKEFFLAHIYTELQLIEEALQKYQHLIDVGFSKSSYIVSQIAVAYHNIRDID 280

  Fly   268 KAIELYQALLESDPYRLDNVDTYSNLLFVKEMKTEMAQLAHKAVSINKYRPETCCVIGNYYSIRC 332
            ||:.::..|.:.||||::|:||:||||:|:.||:|::.|||....|:|||.|||||||||||:|.
  Rat   281 KALSIFNELRKQDPYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRS 345

  Fly   333 DHQVAISYFQRALKLNPKYLAAWTLMGHEFMELKNTNAAIQSYRKAVEVNKRDYRAWYGLGQAYE 397
            .|:.|..||||||||||:||.||||||||:||:|||:||||:||.|:|||||||||||||||.||
  Rat   346 QHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYE 410

  Fly   398 IIKMHYYSLYYFKIAHQLRPYDSRMLVALGETYEKLDKCENAVKCYWKAIDVGDIEGIAMYKLAN 462
            |:||.:|.|||::.||||||.||||||||||.||||::...|.||||:|..|||:|.:|:.|||.
  Rat   411 ILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRAYAVGDVEKMALVKLAK 475

  Fly   463 LHEKLGDHETAVHCYIMYCED-----ERAATDKQSLYQGFITLANYYEKKGEYERAAYYAYKCLD 522
            |||:|.:.|.|..|||.|.:|     |.....::|  ..|..||.||.|...::.|:..|.||..
  Rat   476 LHEQLTESEQAAQCYIKYIQDIYSCGETVEHLEES--TAFRYLAQYYFKCKLWDEASTCAQKCCA 538

  Fly   523 SEDRKMEAKALLKTIDWKRNAEGQKKVKTSTAVANADTSSEDEMEWELQDVRVRVPITSIATTTT 587
            ..|.:.|.||||:.|...||   |.:..||      ||                 |.|.....:.
  Rat   539 FNDTREEGKALLRQILQLRN---QGETPTS------DT-----------------PGTFFLPASL 577

  Fly   588 STTTVAAESASSSSLISLRP 607
            |.........|..:|.|:.|
  Rat   578 SANNTPTRRVSPLNLSSVTP 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdc23	NP_610036.2	ANAPC8	13..119	CDD:427675	39/106 (37%)
		LapB	255..521	CDD:442196	159/270 (59%)
		TPR repeat	255..278	CDD:276809	11/22 (50%)
		TPR repeat	318..346	CDD:276809	19/27 (70%)
		TPR repeat	351..381	CDD:276809	22/29 (76%)
		TPR repeat	386..414	CDD:276809	19/27 (70%)
		TPR repeat	420..448	CDD:276809	19/27 (70%)
		TPR repeat	454..477	CDD:276809	10/22 (45%)
		TPR repeat	494..522	CDD:276809	10/27 (37%)
Cdc23	NP_001094129.1	ANAPC8	45..148	CDD:427675	38/102 (37%)
		TPR repeat	172..197	CDD:276809	12/24 (50%)
		TPR repeat	202..257	CDD:276809	24/54 (44%)
		Spy	234..>405	CDD:443119	105/170 (62%)
		TPR repeat	263..291	CDD:276809	12/27 (44%)
		TPR	325..>495	CDD:440225	117/169 (69%)
		TPR repeat	331..359	CDD:276809	19/27 (70%)
		TPR repeat	367..393	CDD:276809	19/25 (76%)
		TPR repeat	398..428	CDD:276809	21/29 (72%)
		TPR repeat	433..461	CDD:276809	19/27 (70%)
		TPR repeat	467..495	CDD:276809	14/27 (52%)
		TPR repeat	501..536	CDD:276809	11/34 (32%)