DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cdc23 and AARS1

DIOPT Version :10

Sequence 1:NP_610036.2 Gene:Cdc23 / 35315 FlyBaseID:FBgn0032863 Length:678 Species:Drosophila melanogaster
Sequence 2:NP_001596.2 Gene:AARS1 / 16 HGNCID:20 Length:968 Species:Homo sapiens


Alignment Length:498 Identity:101/498 - (20%)
Similarity:163/498 - (32%) Gaps:156/498 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   210 QLGGHWMRHFFMAHTYLELYLNDDGLKIYE---------DLQASGF-----SKSIYL---IAQMA 257
            ::||....|.          :|.|...:.|         :.:|.|.     .|||..   :.::.
Human   194 RIGGRDAAHL----------VNQDDPNVLEIWNLVFIQYNREADGILKPLPKKSIDTGMGLERLV 248

  Fly   258 LVYHNKR---DVDKAIELYQALLE---SDPYR-------LDNVDTYSNLLFVKEMKTEMAQLAHK 309
            .|..||.   |.|..:..::|:.:   :.||.       .|.:|....:| ....:|....||..
Human   249 SVLQNKMSNYDTDLFVPYFEAIQKGTGARPYTGKVGAEDADGIDMAYRVL-ADHARTITVALADG 312

  Fly   310 AVSINKYRPETCCVIGNYYSIRCDHQVAISYFQRALKLNPKYLAAWTL-------MGHEFMELKN 367
            .      ||:.   .|..|.:|...:.|:.|....|..:..:.|  ||       :|..|.|||.
Human   313 G------RPDN---TGRGYVLRRILRRAVRYAHEKLNASRGFFA--TLVDVVVQSLGDAFPELKK 366

  Fly   368 TNAAIQSYRKAVEVNKRDYRAWYGLGQAYEIIKMHYYSLYYFKIAHQLRPYDSRMLVALGETYEK 432
            ....::..     :|:.:.:....|.:...|:.....||...|..    |.|:..|:     |: 
Human   367 DPDMVKDI-----INEEEVQFLKTLSRGRRILDRKIQSLGDSKTI----PGDTAWLL-----YD- 416

  Fly   433 LDKCENAVKCYWKAID-----------VGDIEGI-AMYKLANLHE--KLGDHETAVHCYIMYCED 483
                     .|...:|           |.|::|. ...|||.|..  |....|..:...|...|:
Human   417 ---------TYGFPVDLTGLIAEEKGLVVDMDGFEEERKLAQLKSQGKGAGGEDLIMLDIYAIEE 472

  Fly   484 ERA----ATDKQSLYQGFITLANYY-EKKGEY----ERAAYYAYK----CLDSEDRKMEAKALL- 534
            .||    .||....|       ||: :..|.|    ..|...|.:    .::......|...:| 
Human   473 LRARGLEVTDDSPKY-------NYHLDSSGSYVFENTVATVMALRREKMFVEEVSTGQECGVVLD 530

  Fly   535 KTIDWKRNAEGQKKVKTSTAVANADTSSEDEMEWELQDVRV------------------------ 575
            ||..:   ||...::.....:...|.||||:.|:.:::.:|                        
Human   531 KTCFY---AEQGGQIYDEGYLVKVDDSSEDKTEFTVKNAQVRGGYVLHIGTIYGDLKVGDQVWLF 592

  Fly   576 -----RVPITSIATTT----TSTTTVAAESASSSSLISLRPDR 609
                 |.||.|..|.|    .:..:|..|:....||::  |||
Human   593 IDEPRRRPIMSNHTATHILNFALRSVLGEADQKGSLVA--PDR 633

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cdc23NP_610036.2 ANAPC8 13..119 CDD:427675
LapB 255..521 CDD:442196 64/312 (21%)
TPR repeat 255..278 CDD:276809 6/25 (24%)
TPR repeat 318..346 CDD:276809 6/27 (22%)
TPR repeat 351..381 CDD:276809 8/36 (22%)
TPR repeat 386..414 CDD:276809 5/27 (19%)
TPR repeat 420..448 CDD:276809 3/27 (11%)
TPR repeat 454..477 CDD:276809 7/25 (28%)
TPR repeat 494..522 CDD:276809 7/36 (19%)
AARS1NP_001596.2 PLN02900 6..961 CDD:215487 101/498 (20%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:38512451 750..763
Blue background indicates that the domain is not in the aligned region.

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