DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10949 and brwl

DIOPT Version :9

Sequence 1:	NP_001286101.1	Gene:	CG10949 / 35310	FlyBaseID:	FBgn0032858	Length:	459	Species:	Drosophila melanogaster
Sequence 2:	NP_609298.1	Gene:	brwl / 34275	FlyBaseID:	FBgn0032130	Length:	435	Species:	Drosophila melanogaster

Alignment Length:	383	Identity:	89/383 - (23%)
Similarity:	140/383 - (36%)	Gaps:	99/383 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 DDLLNEQLIELVKSHPVLYDRHKIRVSKNLAAKNEAWREISENLNVSEELCYNRWKKLRDRFGRE 198
            |:..|.:.:.||::|..|||: |:...:|...:.:||..||:....|...|..||:.||....|.
  Fly    54 DEDFNIRFVNLVRTHKCLYDK-KVPEYRNRDNQEKAWVLISKETRESVIHCKERWRNLRACLSRY 117

  Fly   199 FRSHQINQSTPITWRYFNDLLFLGRHFRKGVPLVLENIKRRGRPPKAGNPSGKT---------SK 254
            .:  |.:.|.|....|     :|..|....:|.:     :..|....||.|..|         ..
  Fly   118 IK--QQSGSEPQHKPY-----YLTEHMAFLLPFL-----KSSRNSLEGNNSLATLYQMSQQHLQH 170

  Fly   255 QP---EGMVISSGEQIWGADYPYSTDNDDLEDDLELAYDEEIEILSEAEQATPYDFILSEATARQ 316
            ||   ...:.::.|..:.|:  .|.:|::..:|:.  ..|.:|:|.       ..:.:||   :.
  Fly   171 QPFLLHPALHATEEHKYCAN--TSINNNNNNNDVH--NGESMEVLE-------MKYSISE---KD 221

  Fly   317 DLEPPQQLQVTTTTPATSEEIIHTIA--RVNPVVEESSSLPGDSVPSAAISDKLLTTVIANMETV 379
            |.|         |..|....:.:|:.  |.:.....||:|.|....|.|.||   |....:|:..
  Fly   222 DEE---------TIDAFDPAVTNTLGMNRTSSTPTRSSALQGGGGNSPARSD---TASADSMKNF 274

  Fly   380 LQ--QSRELQAQI-----------------------------HHEQEQE----REQRSTQPANSL 409
            :.  |..|..:|:                             ||....|    :..::...|.|.
  Fly   275 IPDVQLAETGSQLIYSDGGHGTPPPLHYHPHSHPHPLTLSMDHHPASYEPGSTKRIKTECEATST 339

  Fly   410 LAKAQMLLDGLSPSERASAE--RKIVQFLC----QCQIKALDG--EEIEDVA---PCQ 456
            :..|..:..|||.||.|..|  |.|:..|.    |.:.|...|  |.|:||.   |.|
  Fly   340 MTNAGSIYGGLSSSEVADMEFFRSILPDLATLTPQQRRKFKIGILELIDDVVTRYPAQ 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10949	NP_001286101.1	MADF	5..91	CDD:214738
CG10949	NP_001286101.1	MADF	140..226	CDD:214738	25/85 (29%)
brwl	NP_609298.1	MADF	60..145	CDD:214738	26/97 (27%)
brwl	NP_609298.1	BESS	356..389	CDD:281011	10/32 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438468
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12243
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940