DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and UGT2A3

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	XP_011530549.1	Gene:	UGT2A3 / 79799	HGNCID:	28528	Length:	533	Species:	Homo sapiens

Alignment Length:	558	Identity:	129/558 - (23%)
Similarity:	243/558 - (43%)	Gaps:	71/558 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RTKSYFVIVLALTLLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLEPTITH 68
            |:....::.|.|.|...|......:.::| ...||.:....:.:.|..:||.|||       :||
Human     2 RSDKSALVFLLLQLFCVGCGFCGKVLVWP-CDMSHWLNVKVILEELIVRGHEVTV-------LTH 58

  Fly    69 KNINLVTVPMTKEEIKQRSETIGAKQKNTSSNR-FISI-LN-MSGQMDSMLRKMADVLKDQRVKE 130
            ...:|:..   ::....:.|.:...|..|..|. |:.: || :.|     |.....|:|   :.:
Human    59 SKPSLIDY---RKPSALKFEVVHMPQDRTEENEIFVDLALNVLPG-----LSTWQSVIK---LND 112

  Fly   131 LYLNKDNHFDLVISGYFMNDYQLGFARKVNAPVVVLAP-SPPSQMLNSLIGNPH---------DK 185
            .::.......::...:..|...:...::.|..|:::.| .|...::..|:..|.         ..
Human   113 FFVEIRGTLKMMCESFIYNQTLMKKLQETNYDVMLIDPVIPCGDLMAELLAVPFVLTLRISVGGN 177

  Fly   186 VEKEKG-------------------MTFGQRLDSYISSLLYGIFLRQIDQRN-RQYYNEIFGDDP 230
            :|:..|                   |||.:|:.:.:.|:|:..:::..|... .::|::..|...
Human   178 MERSCGKLPAPLSYVPVPMTGLTDRMTFLERVKNSMLSVLFHFWIQDYDYHFWEEFYSKALGRPT 242

  Fly   231 TMPEYTDILRNTSLVFFCSHAASEGPIRPSVPAAIEIGGIQIKDKPDPLPK------NLEKFL-G 288
            |:.|   .:....:....::...|.| :|..|....:||:..| ....|||      .:|.|: .
Human   243 TLCE---TVGKAEIWLIRTYWDFEFP-QPYQPNFEFVGGLHCK-PAKALPKINFYLQEMENFVQS 302

  Fly   289 NATHGAILLSLGSNVQGSHIKADTVKKIFSVLSNLKQRVIWKWDDLDKTPGKSDNILYSRWLPQD 353
            :...|.::.||||..|  ::..:....|.|.|:.:.|:|:|::.....:...::..||. |:||:
Human   303 SGEDGIVVFSLGSLFQ--NVTEEKANIIASALAQIPQKVLWRYKGKKPSTLGANTRLYD-WIPQN 364

  Fly   354 DILAHPSVKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPF 418
            |:|.||..|.||.|.|..||.||.|||.||:.:|:||||..|...|...|..:.::..|:..|..
Human   365 DLLGHPKTKAFITHGGMNGIYEAIYHGVPMVGVPIFGDQLDNIAHMKAKGAAVEINFKTMTSEDL 429

  Fly   419 RAAVLEILSNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVHMDFIAANN 483
            ..|:..::::..|.:..::.|.::.|:|....:..:||.|:|:||.||.||:|....:.:....:
Human   430 LRALRTVITDSSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRSAAHDLTWFQHYS 494

  Fly   484 LDIYALIGAISIGLLLMLKKVVQITCRRLRTKLNKVKK 521
            :|:...:.|.....:.:..|....:|:    |.||.:|
Human   495 IDVIGFLLACVATAIFLFTKCFLFSCQ----KFNKTRK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	105/470 (22%)
UGT2A3	XP_011530549.1	UDPGT	24..528	CDD:278624	123/534 (23%)
UGT2A3	XP_011530549.1	egt	<267..498	CDD:223071	72/234 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150245
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840