Protein Alignment Ugt37A1 and UGT2B17

DIOPT Version :10

• Sequence 1: NP_523607.2
• Gene: Ugt37A1 / 35307
• FlyBaseID: FBgn0026756
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_001068.1
• Gene: UGT2B17 / 7367
• HGNCID: 12547
• Length: 530
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 149/570 - (26%)
• Similarity: 258/570 - (45%)
• Gaps: 106/570 - (18%)

  Fly    11 IVLALTLLIYGAQGA--NILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVT----VLEPTITHK 69
            :.|.:.|..|.:.|:  .:| ::|: ..||.|...::.:.|.::||.|.|:|    :|.......
Human     8 VFLLMQLSCYFSSGSCGKVL-VWPT-EYSHWINMKTILEELVQRGHEVIVLTSSASILVNASKSS 70

  Fly    70 NINLVTVP--MTKEEI-----KQRSETIGAKQKNTSSNRFISILNMSGQMDSMLRKMADVLKDQR 127
            .|.|...|  :||.::     |.......:..|||..:.|           |.|:::.....|..
Human    71 AIKLEVYPTSLTKNDLEDFFMKMFDRWTYSISKNTFWSYF-----------SQLQELCWEYSDYN 124

  Fly   128 VK---ELYLNK-------DNHFDLVISGYFMNDYQLGFARKVNAPVVVLAPSPPSQMLNSLIGNP 182
            :|   :..|||       ::.||::::.                     |.:|..::|..|:..|
Human   125 IKLCEDAVLNKKLMRKLQESKFDVLLAD---------------------AVNPCGELLAELLNIP 168

  Fly   183 H---------DKVEKEKG-------------------MTFGQRLDSYISSLLYGIFLRQIDQRN- 218
            .         ..|||..|                   |.|.:|:.:.|..|.:..:.:..|.:.
Human   169 FLYSLRFSVGYTVEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIYMLYFDFWFQAYDLKKW 233

  Fly   219 RQYYNEIFGDDPTMPEYTDILRNTSLVFFCSHAASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNL 283
            .|:|:|:.|...|:.|   .:....:....::...|.| ||.:|....:||:..| ...||||.:
Human   234 DQFYSEVLGRPTTLFE---TMGKAEMWLIRTYWDFEFP-RPFLPNVDFVGGLHCK-PAKPLPKEM 293

  Fly   284 EKFL-GNATHGAILLSLGSNVQGSHIKADTVKKIFSVLSNLKQRVIWKWDDLDKTPGKSDNILYS 347
            |:|: .:..:|.::.||||.:  |::..::...|.|.|:.:.|:|:|::|      ||..|.|.|
Human   294 EEFVQSSGENGIVVFSLGSMI--SNMSEESANMIASALAQIPQKVLWRFD------GKKPNTLGS 350

  Fly   348 -----RWLPQDDILAHPSVKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLT 407
                 :||||:|:|.||..|.||.|.|..||.||.|||.||:.:|:|.||..|...|...|..|:
Human   351 NTRLYKWLPQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALS 415

  Fly   408 LSLLTLEEEPFRAAVLEILSNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSP 472
            :.:.|:.......|:..::::|.|.:.::|.|.::.|:|....:..:||.|:|:||.||.||:..
Human   416 VDIRTMSSRDLLNALKSVINDPIYKENIMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVA 480

  Fly   473 LVHMDFIAANNLDIYALIGAISIGLLLMLKKVVQITCRRLRTKLNKVKKQ 522
            ..::.:|..::||:.|.:.|....::.|:.|.. :.|.|...|..|.||:
Human   481 AHNLTWIQYHSLDVIAFLLACVATMIFMITKCC-LFCFRKLAKTGKKKKR 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	122/488 (25%)
UGT2B17	NP_001068.1	UDPGT	24..518	CDD:278624	140/541 (26%)