DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and UGT2B10

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001066.1	Gene:	UGT2B10 / 7365	HGNCID:	12544	Length:	528	Species:	Homo sapiens

Alignment Length:	526	Identity:	142/526 - (26%)
Similarity:	248/526 - (47%)	Gaps:	58/526 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VLALTLLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVV----TVLEPTITHKNIN 72
            ||.:.|..|.:.|:....|..:...|..:...::.|.|.::||.|||:    ::|........:.
Human     8 VLLIQLSFYFSSGSCGKVLVWAAEYSLWMNMKTILKELVQRGHEVTVLASSASILFDPNDSSTLK 72

  Fly    73 LVTVP--MTKEE----IKQRSETIGAKQKNTSSNRFISILNMSGQMDSMLRKMA-DVLKDQR-VK 129
            |...|  :||.|    |.|..:.:...||:|....|.....:...::.::|... ||:.::: :|
Human    73 LEVYPTSLTKTEFENIIMQLVKRLSEIQKDTFWLPFSQEQEILWAINDIIRNFCKDVVSNKKLMK 137

  Fly   130 ELYLNKDNHFDLVISGYFMNDYQLGFARKVNAPVVV---LAPS------------PPSQMLNSLI 179
            :|   :::.||:|.:..::...:| .|...|.|.|.   .:|.            |||.:
Human   138 KL---QESRFDIVFADAYLPCGEL-LAELFNIPFVYSHSFSPGYSFERHSGGFIFPPSYV----- 193

  Fly   180 GNPHDKVEKEKGMTFGQRLDSYISSLLYGIFLRQIDQRNR--QYYNEIFGDDPTMPE---YTDI- 238
              |....:....|||.:|:.:.: .:||..|..||....:  |:|:|:.|...|:.|   ..||
Human   194 --PVVMSKLSDQMTFMERVKNML-YVLYFDFWFQIFNMKKWDQFYSEVLGRPTTLSETMRKADIW 255

  Fly   239 LRNTSLVFFCSHAASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFL-GNATHGAILLSLGSN 302
            |...|..|...|        |.:|....:||:..| ...||||.:|:|: .:..:|.::.||||.
Human   256 LMRNSWNFKFPH--------PFLPNVDFVGGLHCK-PAKPLPKEMEEFVQSSGENGVVVFSLGSM 311

  Fly   303 VQGSHIKADTVKKIFSVLSNLKQRVIWKWDDLDKTPGKSDNILYSRWLPQDDILAHPSVKLFINH 367
            |  |::..:....|.:.|:.:.|:|:|::|. :|......|....:|:||:|:|.||..:.||.|
Human   312 V--SNMTEERANVIATALAKIPQKVLWRFDG-NKPDALGLNTRLYKWIPQNDLLGHPKTRAFITH 373

  Fly   368 AGKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRAAVLEILSNPKYS 432
            .|..||.||.|||.||:.:|:|.|||.|...|...|..:.:...|:.......|:..::::|.|.
Human   374 GGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRVDFNTMSSTDLLNALKTVINDPSYK 438

  Fly   433 QRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVHMDFIAANNLDIYALIGAISIGL 497
            :.::|.|.:..|:|....:..:||.|:|:||.||.||:....::.:...::||:...:.|....:
Human   439 ENIMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWFQYHSLDVIGFLLACVATV 503

  Fly   498 LLMLKK 503
            |.::.|
Human   504 LFIITK 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	122/464 (26%)
UGT2B10	NP_001066.1	UDPGT	23..524	CDD:278624	137/511 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150532
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840