DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and Ugt2a3

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_082370.2	Gene:	Ugt2a3 / 72094	MGIID:	1919344	Length:	534	Species:	Mus musculus

Alignment Length:	528	Identity:	140/528 - (26%)
Similarity:	230/528 - (43%)	Gaps:	82/528 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SHLIISMSVAKILAEQGHNVTVVTVLEPTITHKNINLVTVPMTKEEIKQRSETIGAKQKNTSSNR 101
            ||.:...::.:.|..:||.|||:......|....    .:|:..|.|....|.      .|:.||
Mouse    34 SHWLNLKTILEELGARGHEVTVLKYPSIIIDQSK----RIPLHFENIPLLYEI------ETAENR 88

  Fly   102 FISILNMSGQM--DSMLRKMADVLKDQRVKELYLNKDNHFDLVISGYFMNDYQLGFARKVNAPVV 164
            ...|.|::..:  :..|.:.|..|:|     .:|.....|:.:......|...:...|.....||
Mouse    89 LNEIANLAVNVIPNLSLWEAAKTLQD-----FFLQVTGDFESICRSVLYNQKFMDKLRDAQYDVV 148

  Fly   165 VLAPSPP-SQMLNSLIGNPH---------DKVEKEKG-------------------MTFGQRLDS 200
            |:.|..| .:::..::..|.         ..:||..|                   |||.:|:.:
Mouse   149 VIDPVVPCGELVAEVLQIPFVYTLRFSMGYYMEKHCGQLPIPLSYVPVVMSELTDNMTFTERVKN 213

  Fly   201 YISSLLYGIFLRQIDQRN-RQYYNEIFGDDPTMPEYTDILRNTSLVFFCSHAAS----------- 253
            .:.|||:..:|:|.|... .|:|:|..|...|               ||.....
Mouse   214 MMFSLLFEYWLQQYDFAFWDQFYSETLGRPTT---------------FCKTVGKADIWLIRTYWD 263

  Fly   254 -EGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFL-GNATHGAILLSLGSNVQGSHIKADTVKKI 316
             |.| ||.:|....:||:..| ...||||.:|:|: .:..||.::.||||.|:  ::..:....|
Mouse   264 VEFP-RPYLPNFEFVGGLHCK-PAKPLPKEMEEFVQSSGEHGVVVFSLGSMVK--NLTEEKANLI 324

  Fly   317 FSVLSNLKQRVIWKWDDLDKTPGK-SDNILYSRWLPQDDILAHPSVKLFINHAGKGGISEAQYHG 380
            .|||:.:.|:|:|::.  .|.|.. ..|.....|:||:|:|.||..|.||.|.|..||.||.|||
Mouse   325 ASVLAQIPQKVLWRYS--GKKPATLGSNTRLFNWIPQNDLLGHPKTKAFITHGGTNGIYEAIYHG 387

  Fly   381 KPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRAAVLEILSNPKYSQRVVKFSSLYRDR 445
            .||:.:|:.||||.|...|...|..|.:|:.|:......:||..:::.|.|.:..::.|.::.|:
Mouse   388 VPMVGVPMLGDQPHNIAHMEAKGAALKVSISTMTSTDLLSAVRAVINEPSYKENAMRLSRIHHDQ 452

  Fly   446 PASARESLIFWTEYVIRHHGAAHLQSPLVHMDFIAANNLDIYALIGAISIGLLLMLKKVVQITCR 510
            |....:..:||.|:|:||.||.||:.....:.:...::||:...:....:.|..::.|.....|:
Mouse   453 PVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWFQYHSLDVIGFLLLCVVTLTFIITKFCLFVCQ 517

  Fly   511 RLRTKLNK 518
            :|..|.:|
Mouse   518 KLYMKESK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	122/464 (26%)
Ugt2a3	NP_082370.2	UDPGT	25..526	CDD:278624	140/528 (27%)
Ugt2a3	NP_082370.2	egt	<268..507	CDD:223071	81/243 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840296
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840