DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and Ugt2b1

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_690024.1	Gene:	Ugt2b1 / 71773	MGIID:	1919023	Length:	529	Species:	Mus musculus

Alignment Length:	554	Identity:	140/554 - (25%)
Similarity:	269/554 - (48%)	Gaps:	69/554 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SYFVIVLALTLLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVV----TVLEPTIT 67
            |.|:::..:..:..||.|..:  ::|: ..||.|....:...|.::||:|||:    ::|.....
Mouse     7 SVFLLIQFICYIRPGACGKVL--VWPT-EYSHWINMKIILDELVQRGHDVTVLISSASILIGPSN 68

  Fly    68 HKNIN--LVTVPMTKEEIKQRSET-IG----AKQKNTSSNRFISILNMSGQMDSMLRKM--ADVL 123
            ..:||  :.:.|::|::::...|. :|    ..:|......:..:..:|.:...|:...  |.|.
Mouse    69 ESSINFEIYSAPLSKDDLEYAFEKWVGNWTYELKKLPFWTSYSKLQKISSEYSDMIESFCKAVVW 133

  Fly   124 KDQRVKELYLNKDNHFDLVIS------GYFMND-------YQLGF-----ARKVNAPVVVLAPSP 170
            ....:|:|..:|   ||:|::      |..:::       |.|.|     ..|.:..:    |.|
Mouse   134 NKSLMKKLQGSK---FDVVLADALVPCGELLSELLKTPLVYSLRFCPGYKCEKYSGGL----PLP 191

  Fly   171 PSQMLNSLIGNPHDKVEKEKGMTFGQRLDSYISSLLYGIFLRQIDQRN-RQYYNEIFGDDPTMPE 234
            ||.:       |....|....|||.:|:.:.:..||:..:.:..:::: .|:|:::.|...|:
Mouse   192 PSYV-------PVVLSELSDHMTFAERVKNMLQVLLFDFWFQTFNEKSWNQFYSDVLGRPTTL-- 247

  Fly   235 YTDILRNTSLVFFCSHAASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFL-GNATHGAILLS 298
             |:::....:....:....:.| .|.:|....:||:..| ...||||.:|:|: .:..||.::.|
Mouse   248 -TEMMGKADIWLVRTFWDLKFP-HPFLPNFDFVGGLHCK-PAKPLPKEMEEFVQSSGEHGVVVFS 309

  Fly   299 LGSNVQGSHIKADTVKKIFSVLSNLKQRVIWKWDDLDKTPGKSDNILYS-----RWLPQDDILAH 358
            |||.|:  :||.:....:.|.|:.:.|:|:|::|      ||..:.|.|     :|:||:|:|.|
Mouse   310 LGSMVK--NIKEEKANVVASALAQIPQKVLWRFD------GKKPDTLGSNTRLYKWIPQNDLLGH 366

  Fly   359 PSVKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRAAVL 423
            |..|.||.|.|..||.||.|||.|::.:|:|||||.|.:.:|..|..:.:...|:.......|:.
Mouse   367 PKTKAFIAHGGTNGIYEAIYHGIPIVGIPLFGDQPDNINHIVAKGAAVRVDFDTMSTTDLLTALK 431

  Fly   424 EILSNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVHMDFIAANNLDIYA 488
            .::::|.|.:..::.|.::.|:|....:..:||.|||:|:.||.||:..|..:.:...::||:..
Mouse   432 TVINDPSYKENAMRLSRIHHDQPMKPLDRAVFWIEYVMRNKGAKHLRPALHDLTWFQYHSLDVIG 496

  Fly   489 LIGAISIGLLLMLKKVVQITCRRLRTKLNKVKKQ 522
            .:....:.::.::.|.....|.: ...:.|.||:
Mouse   497 FLLVCVVAVVFIIAKCCLFCCHK-TANMGKKKKE 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	117/468 (25%)
Ugt2b1	NP_690024.1	egt	8..508	CDD:223071	134/529 (25%)
Ugt2b1	NP_690024.1	UDPGT	24..527	CDD:278624	134/533 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840539
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840