DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and ugt5a1

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001032497.2	Gene:	ugt5a1 / 641479	ZFINID:	ZDB-GENE-051120-60	Length:	525	Species:	Danio rerio

Alignment Length:	552	Identity:	156/552 - (28%)
Similarity:	265/552 - (48%)	Gaps:	76/552 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VLALTLLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVT------VLEPTITHKN 70
            :.:|..::.|..|..:| :|| |..||.:....:.:.|..:|||||||.      :.|.:..:.:
Zfish     9 LFSLLCVLSGTYGGKVL-VFP-LDGSHWVNMKVLIEELHRKGHNVTVVRPSNSWYIKEESPFYSS 71

  Fly    71 INLVTVPMT----KE----------EIKQRSETIGAKQKNTSSNRFISILNMSGQMDSMLRKMAD 121
            |   |:|.|    :|          |||:.    |....|.....|..::......:.||:.|..
Zfish    72 I---TIPNTGGFDEEFSGLLINRLLEIKRG----GYFVLNRVRLEFEIMMKFKTMHEDMLQMMDR 129

  Fly   122 VLKDQRVKELYLN--KDNHFDLVISGYFMNDYQLG----FARKVNAPVV-------------VLA 167
            :|:|::|    :|  :|..||:|::     |..:|    .|.|.|.|:|             .:|
Zfish   130 MLEDEKV----MNSIQDAKFDVVLA-----DPAVGGGPILAYKFNIPLVFNVRWTIQGEGHFAIA 185

  Fly   168 PSPPSQMLNSLIGNPHDKVEKEKGMTFGQRLDSYISSLLYGIFLR-QIDQRNRQYYNEIFGDDPT 231
            |||.|.:       |...||....|:|.||:.:.:..|:..|.:: .::.....:.::.||.:.|
Zfish   186 PSPLSYI-------PVPGVELTDKMSFLQRVKNVLIYLISQIQMQIMVEPIYAPFCHKHFGPNVT 243

  Fly   232 MPEYTDILRNTSLVFFCSHAASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFL-GNATHGAI 295
               |..:.::..:....:....|.| ||::|..:.:.|.|.| ...|||.:||||: .:..||.|
Zfish   244 ---YFSLFQDADIWLMRNDFTFEFP-RPTMPNIVYMSGFQCK-PAKPLPNDLEKFVESSGEHGVI 303

  Fly   296 LLSLGSNVQGSHIKADTVKKIFSVLSNLKQRVIWKWDDLDKTPGKSDNILYSRWLPQDDILAHPS 360
            ::|||:.:  :.:..|....|.:..:.|.|:|||::.. .:.....:|.|...||||:|:|.||.
Zfish   304 VMSLGTLI--AQLPQDMTDDIAAAFAELPQKVIWRYTG-PRPVTLGNNTLLVEWLPQNDLLGHPQ 365

  Fly   361 VKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRAAVLEI 425
            :|:|:.|.|..||.||.|||.|:|.||:..|||.|...|...|....:.:.||::..|..|:.|:
Zfish   366 IKVFVAHGGTNGIQEAIYHGVPILGLPLVFDQPDNLFRMEAKGTAKIVDIATLDKTVFLEALKEV 430

  Fly   426 LSNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVHMDFIAANNLDIYALI 490
            |.||.|.:.:.:.|.|:.|:|....:..:||.|:|:|:.||.||::....|.:|..:::|:...:
Zfish   431 LYNPSYRENMQRLSKLHHDQPLKPLDRAMFWIEFVMRNKGAPHLRTQSFRMSWIEYHSIDVILTL 495

  Fly   491 GAISIGLLLMLKKVVQITCRRLRTKLNKVKKQ 522
            ........||:...::..|..:..|  |||::
Zfish   496 MVTGFVFALMIGYTIKYFCLCVFRK--KVKRE 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	134/471 (28%)
ugt5a1	NP_001032497.2	UDPGT	22..525	CDD:278624	153/537 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584466
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.840