DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and Ugt1a8

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001365304.1	Gene:	Ugt1a8 / 613123	MGIID:	3576090	Length:	530	Species:	Mus musculus

Alignment Length:	534	Identity:	153/534 - (28%)
Similarity:	249/534 - (46%)	Gaps:	56/534 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLEPTIT-----HKNINLVT- 75
            ||.:|...|..|.:.| :..||......:.:.|:.:||.|.||.   |.::     .:|..:.|
Mouse    17 LLAFGLAQAGRLLVVP-MDGSHWFSMKMIVEKLSHRGHEVVVVI---PEVSWHLGKSQNFTVKTY 77

  Fly    76 -VPMTKEEIKQRSETIGAKQKNTSSNRFISILNMSGQ--MDSMLRKMADVLKDQRVKELYLNKDN 137
             |..|.|::.........||.........|:|..||:  ...:......:..|:::.| || |..
Mouse    78 SVSYTLEDLSHHFNFFAHKQWENREVGMFSLLKHSGKGFFQVLFSHCRSLFNDKKLVE-YL-KQR 140

  Fly   138 HFDLVISGYFMNDYQ---LGFARKVNAPVVVLA--------------PSPPSQMLNSLIGNPHDK 185
            .||.|    |::.:.   |..|:..:.|.||.:              |||||.:       |...
Mouse   141 SFDAV----FLDPFDVCGLTIAKYFSLPSVVFSGGIFCHYLDEGAQCPSPPSYV-------PRIL 194

  Fly   186 VEKEKGMTFGQRLDSYISSLLYGIFLRQIDQRNRQYYNEIFGDDPTMPEYTDILRNTSLVFFCSH 250
            .:....|||.:|:.:|.|.:....|.....:...:..:|:.....||   ||:..:.|:..|.:.
Mouse   195 SKFADTMTFKERVWNYFSYMKERAFCPYFFKTAIEIASEVLQTPVTM---TDLFSSVSIWMFRTD 256

  Fly   251 AASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFLGNAT--HGAILLSLGSNVQGSHIKADTV 313
            ...|.| ||.:|..:.||||.. ....||.|..|.:: ||:  ||.::.||||.|  |.|.....
Mouse   257 FVLEFP-RPVMPNMVYIGGINC-HPGKPLSKEFEAYV-NASGEHGIVVFSLGSMV--SEIPEKKA 316

  Fly   314 KKIFSVLSNLKQRVIWKWDDLDKTPGKSDNILYSRWLPQDDILAHPSVKLFINHAGKGGISEAQY 378
            .:|...|..:.|.|:|::.. .:....:.|.:..:||||:|:|.||..:.||.|:|..||.|...
Mouse   317 MEIAEALGRIPQTVLWRYTG-TRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGIYEGIC 380

  Fly   379 HGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRAAVLEILSNPKYSQRVVKFSSLYR 443
            :|.||:.:|:||||..||..|...|.|:||::|.:..:....|:..:::|..|.:.:::.|||::
Mouse   381 NGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHK 445

  Fly   444 DRPASARESLIFWTEYVIRHHGAAHLQSPLVH-MDFIAANNLDIYALIGAISIGLLLMLKKVVQI 507
            |||....:..:||.|||:||.||.||: |..| :.:...::||:...:.||.:.::.::.|....
Mouse   446 DRPIEPLDLAVFWVEYVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVFKCCAY 509

  Fly   508 TCRRLRTKLNKVKK 521
            .||:......:|||
Mouse   510 GCRKCFGGKGRVKK 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	127/458 (28%)
Ugt1a8	NP_001365304.1	UDPGT	26..521	CDD:278624	146/521 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840387
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840