Protein Alignment Ugt37A1 and UGT2A2

DIOPT Version :10

• Sequence 1: NP_523607.2
• Gene: Ugt37A1 / 35307
• FlyBaseID: FBgn0026756
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_001099147.2
• Gene: UGT2A2 / 574537
• HGNCID: 28183
• Length: 536
• Species: Homo sapiens
• Alignment Length: 565
• Identity: 141/565 - (24%)
• Similarity: 242/565 - (42%)
• Gaps: 108/565 - (19%)

  Fly    11 IVLALTLLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLEPTITHKN----I 71
            :||:..:||:...|            ||.:....:.:.|.::.|||||:........:.|    :
Human    26 VVLSGNVLIWPTDG------------SHWLNIKIILEELIQRNHNVTVLASSATLFINSNPDSPV 78

  Fly    72 NLVTVPMTKEEIKQRSETIGAKQKNTSSNRFISILNMSGQMDSMLRKMADVLKDQR--------- 127
            |...:|            :..|:.|               :||::..|..:..|.|
Human    79 NFEVIP------------VSYKKSN---------------IDSLIEHMIMLWIDHRPTPLTIWAF 116

  Fly   128 VKELYLNKDNHFDLVI---SGYFMNDYQLGFARKVNAPVVVLAPSPPSQMLNSLIG--------- 180
            .|||....|..|.:.|   .|...|...:...:|....|:|   :.|..:...|:.
Human   117 YKELGKLLDTFFQINIQLCDGVLKNPKLMARLQKGGFDVLV---ADPVTICGDLVALKLGIPFMY 178

  Fly   181 ----NPHDKVEKEKG-------------------MTFGQRLDSYISSLLYGIFLRQIDQRNRQYY 222
                :|...||:..|                   ||||:|:.:.||..|.....:........||
Human   179 TLRFSPASTVERHCGKIPAPVSYVPAALSELTDQMTFGERIKNTISYSLQDYIFQSYWGEWNSYY 243

  Fly   223 NEIFGDDPTMPEYTDILRNTSLVFFCSHAASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFL 287
            ::|.|...|:.|   .:....:....::...|.| ||.:|....:||:..| ...||||.:|:|:
Human   244 SKILGRPTTLCE---TMGKAEIWLIRTYWDFEFP-RPYLPNFEFVGGLHCK-PAKPLPKEMEEFI 303

  Fly   288 -GNATHGAILLSLGSNVQGSHIKADTVKKIFSVLSNLKQRVIWKWDDLDKTPGK-SDNILYSRWL 350
             .:..:|.::.||||.|:  ::..:....|.|.|:.:.|:|:|::.  .|.|.. .:|.....|:
Human   304 QSSGKNGVVVFSLGSMVK--NLTEEKANLIASALAQIPQKVLWRYK--GKKPATLGNNTQLFDWI 364

  Fly   351 PQDDILAHPSVKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEE 415
            ||:|:|.||..|.||.|.|..||.||.|||.||:.:|:|.|||.|...|...|..:.::|.|:..
Human   365 PQNDLLGHPKTKAFITHGGTNGIYEAIYHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTS 429

  Fly   416 EPFRAAVLEILSNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVHMDFIA 480
            ....:|:..:::.|.|.:..::.|.::.|:|....:..:||.|:|:||.||.||:.....:.:..
Human   430 VDLLSALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQ 494

  Fly   481 ANNLDIYALIGAISIGLLLMLKKVVQ---ITCRRLRTKLNKVKKQ 522
            .::||:   ||.:.:.:...:..|:|   .:|::. .|:.|.||:
Human   495 YHSLDV---IGFLLVCVTTAIFLVIQCCLFSCQKF-GKIGKKKKR 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	115/480 (24%)
UGT2A2	NP_001099147.2	UDPGT	30..524	CDD:278624	134/547 (24%)