DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and Ugt1a5

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001034638.1	Gene:	Ugt1a5 / 574523	RGDID:	1583689	Length:	531	Species:	Rattus norvegicus

Alignment Length:	556	Identity:	158/556 - (28%)
Similarity:	259/556 - (46%)	Gaps:	93/556 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LTLLIYG---AQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLEPTITHKNINLVT- 75
            |.||:|.   |:|..:| :|| :..||.:....|.:.|..:||. .||...|.|:..|..:..|
  Rat    13 LLLLLYALPWAEGGKVL-VFP-MEGSHWLSMRDVVRELHARGHQ-AVVLAPEVTVHIKEEDFFTL 74

  Fly    76 ----VPMTKEEIKQRSETIGAKQKNTSSNRFISILNMSGQMDSMLRKMADVLKDQRVKEL----- 131
                ||.|::..:|:            ..|.|.::..:|.......:.:::||:.....|
  Rat    75 QTYPVPYTRQGFRQQ------------MMRNIKVVFETGNYVKTFLETSEILKNISTVLLRSCMN 127

  Fly   132 ---------YLNKDNHFDLVIS------GYFMNDYQLG-----FARKVNAPV---VVLAPSPPSQ 173
                     :||..: ||:|::      |..:..| ||     |.|.:...:   ....|.|.|.
  Rat   128 LLHNGSLLQHLNSSS-FDMVLTDPVIPCGAVLAKY-LGIPTVFFLRYIPCGIDSEATQCPKPSSY 190

  Fly   174 MLNSL-IGNPHDKVEKEKGMTFGQRLDSYISSLLYGIFLRQIDQRNRQYYNEIFGDDPTMPEYTD 237
            :.|.| :.:.|        |||.||    :.::||.:.|:.|...:...|..:         .::
  Rat   191 IPNLLTMLSDH--------MTFLQR----VKNMLYPLALKYICHFSFTRYESL---------ASE 234

  Fly   238 IL-RNTSLVFFCSHAA---SEGPI-----RPSVPAAIEIGGIQIKDKPDPLPKNLEKFLGNAT-- 291
            :| |..|||...|||:   ..|..     ||.:|..:.||||....| .||.:..|.:: ||:
  Rat   235 LLQREVSLVEVLSHASVWLFRGDFVFDYPRPVMPNMVFIGGINCVIK-KPLSQEFEAYV-NASGE 297

  Fly   292 HGAILLSLGSNVQGSHIKADTVKKIFSVLSNLKQRVIWKWDDLDKTPGKSDNILYSRWLPQDDIL 356
            ||.::.||||.|  |.|......:|...|..:.|.|:|::.. .:....:.|.:..:||||:|:|
  Rat   298 HGIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTG-TRPSNLAKNTILVKWLPQNDLL 359

  Fly   357 AHPSVKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRAA 421
            .||..:.||.|:|..||.|...:|.||:.:|:||||..||..|...|.|:||::|.:..:....|
  Rat   360 GHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENA 424

  Fly   422 VLEILSNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVH-MDFIAANNLD 485
            :..:::|..|.:.:::.|||::|||....:..:||.|||:||.||.||: |..| :.:...::||
  Rat   425 LKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLR-PAAHDLTWYQYHSLD 488

  Fly   486 IYALIGAISIGLLLMLKKVVQITCRRLRTKLNKVKK 521
            :...:.||.:.::.::.|.....||:......:|||
  Rat   489 VIGFLLAIVLTVVFIVYKSCAYGCRKCFGGKGRVKK 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	129/475 (27%)
Ugt1a5	NP_001034638.1	UDPGT	26..522	CDD:278624	149/539 (28%)
Ugt1a5	NP_001034638.1	egt	<259..505	CDD:223071	85/251 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344056
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840