Protein Alignment Ugt37A1 and Ugt1a5

DIOPT Version :10

• Sequence 1: NP_523607.2
• Gene: Ugt37A1 / 35307
• FlyBaseID: FBgn0026756
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_001034638.1
• Gene: Ugt1a5 / 574523
• RGDID: 1583689
• Length: 531
• Species: Rattus norvegicus
• Alignment Length: 556
• Identity: 158/556 - (28%)
• Similarity: 259/556 - (46%)
• Gaps: 93/556 - (16%)

  Fly    15 LTLLIYG---AQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLEPTITHKNINLVT- 75
            |.||:|.   |:|..:| :|| :..||.:....|.:.|..:||. .||...|.|:..|..:..|
  Rat    13 LLLLLYALPWAEGGKVL-VFP-MEGSHWLSMRDVVRELHARGHQ-AVVLAPEVTVHIKEEDFFTL 74

  Fly    76 ----VPMTKEEIKQRSETIGAKQKNTSSNRFISILNMSGQMDSMLRKMADVLKDQRVKEL----- 131
                ||.|::..:|:            ..|.|.::..:|.......:.:::||:.....|
  Rat    75 QTYPVPYTRQGFRQQ------------MMRNIKVVFETGNYVKTFLETSEILKNISTVLLRSCMN 127

  Fly   132 ---------YLNKDNHFDLVIS------GYFMNDYQLG-----FARKVNAPV---VVLAPSPPSQ 173
                     :||..: ||:|::      |..:..| ||     |.|.:...:   ....|.|.|.
  Rat   128 LLHNGSLLQHLNSSS-FDMVLTDPVIPCGAVLAKY-LGIPTVFFLRYIPCGIDSEATQCPKPSSY 190

  Fly   174 MLNSL-IGNPHDKVEKEKGMTFGQRLDSYISSLLYGIFLRQIDQRNRQYYNEIFGDDPTMPEYTD 237
            :.|.| :.:.|        |||.||    :.::||.:.|:.|...:...|..:         .::
  Rat   191 IPNLLTMLSDH--------MTFLQR----VKNMLYPLALKYICHFSFTRYESL---------ASE 234

  Fly   238 IL-RNTSLVFFCSHAA---SEGPI-----RPSVPAAIEIGGIQIKDKPDPLPKNLEKFLGNAT-- 291
            :| |..|||...|||:   ..|..     ||.:|..:.||||....| .||.:..|.:: ||:
  Rat   235 LLQREVSLVEVLSHASVWLFRGDFVFDYPRPVMPNMVFIGGINCVIK-KPLSQEFEAYV-NASGE 297

  Fly   292 HGAILLSLGSNVQGSHIKADTVKKIFSVLSNLKQRVIWKWDDLDKTPGKSDNILYSRWLPQDDIL 356
            ||.::.||||.|  |.|......:|...|..:.|.|:|::.. .:....:.|.:..:||||:|:|
  Rat   298 HGIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTG-TRPSNLAKNTILVKWLPQNDLL 359

  Fly   357 AHPSVKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRAA 421
            .||..:.||.|:|..||.|...:|.||:.:|:||||..||..|...|.|:||::|.:..:....|
  Rat   360 GHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENA 424

  Fly   422 VLEILSNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVH-MDFIAANNLD 485
            :..:::|..|.:.:::.|||::|||....:..:||.|||:||.||.||: |..| :.:...::||
  Rat   425 LKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLR-PAAHDLTWYQYHSLD 488

  Fly   486 IYALIGAISIGLLLMLKKVVQITCRRLRTKLNKVKK 521
            :...:.||.:.::.::.|.....||:......:|||
  Rat   489 VIGFLLAIVLTVVFIVYKSCAYGCRKCFGGKGRVKK 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	129/475 (27%)
Ugt1a5	NP_001034638.1	UDPGT	26..522	CDD:278624	149/539 (28%)