DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt37A1 and ugt8

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001037790.2	Gene:	ugt8 / 553508	ZFINID:	ZDB-GENE-060616-129	Length:	541	Species:	Danio rerio

Alignment Length:	531	Identity:	144/531 - (27%)
Similarity:	251/531 - (47%)	Gaps:	79/531 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KSYFVIVLALTLLIYG-AQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLE----PT 65
            |::||:...|..|... :..|.|:.:.|.:..|||.|..::|..|..:||: ||..|.|    |.
Zfish     2 KAFFVLATLLWCLATSLSWAAKIVVVPPIMFESHLYIFKTLASALHAEGHD-TVFLVSEGREIPP 65

  Fly    66 ITHKNINLVTVPMTKEEIKQR----------SETIGAKQKNTSSNRFISILNMSGQMDSMLRKMA 120
            ..|..:             ||          .:.:.:|.:|..|.| ::.|.:...:|...:...
Zfish    66 SNHYRL-------------QRYPGIFNSTSADDFLQSKVRNIFSGR-LTALELFDILDHYSQNCD 116

  Fly   121 DVLKDQRVKELYLNKDNHFDLVI------SGYFMNDYQLG-----FARKVNAPVVVLAPSPPSQM 174
            .|:....|.|..  |..||||::      .| |:..:.||     |:..:..|..|.||:|.|.:
Zfish   117 AVVGSTSVMEQL--KREHFDLLLVDPNEMCG-FVIAHILGVQYAVFSTGLWYPAEVGAPAPLSYV 178

  Fly   175 --LNSLIGNPHDKVEKEKGMTFGQRLDS---YISSLLYGI---FLRQIDQRNRQYYNEIFGDDPT 231
              .|||: ..|        |:..||:.:   |:.| .:|:   .|.:.|:..|:|     ...|:
Zfish   179 PEFNSLL-TDH--------MSLFQRVANTAVYLVS-RFGVQFLVLPKYDRIMRKY-----NIQPS 228

  Fly   232 MPEYTDILRNTSLVFFCSHAASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFLGNATH-GAI 295
            :..: |:::|:.|...|:..|.|.| ||::|..:.:|||..| .|.|||:..|.::.:... |.:
Zfish   229 VSMH-DLVQNSRLWMLCTDMALEFP-RPTLPHVVYVGGILTK-PPSPLPQEFETWVKDTDEDGFV 290

  Fly   296 LLSLGSNVQGSHIKADTVKKIFSVLSNLKQRVIWKWDDLDKTPGKSDNILYSRWLPQDDILAHPS 360
            ::|.|:.|:  ::..|..:|:...||.|.|||||::..:..: ...:|.....|:||:|:|...:
Zfish   291 VVSFGAGVK--YLSDDIAQKLAGALSRLPQRVIWRFSGVPPS-NLGNNTKLVDWMPQNDLLGQTN 352

  Fly   361 VKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRAAVLEI 425
            .:.|::|.|...|.||.|||.|::.:|:|||.......:...|.|:.|....:.||....|::.:
Zfish   353 TRAFLSHGGLNSIYEAMYHGVPVVGVPLFGDHYDTMTRVQAKGMGIMLEWKRMSEEDLYTAMVNV 417

  Fly   426 LSNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVHMDFIAANNLDIYALI 490
            :::.:|.:|....|.:::|:|.......::|..|::||.||.||:|.:..:.......||:
Zfish   418 ITDKRYRERAQLLSQIHKDQPGHPVSRAVYWISYILRHRGAEHLRSAVYEIPTYQYFLLDV---- 478

  Fly   491 GAISIGLLLML 501
             |:.||:.|:|
Zfish   479 -AMVIGVCLLL 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	123/464 (27%)
ugt8	NP_001037790.2	UDPGT	22..500	CDD:330975	139/511 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585190
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.840