Protein Alignment Ugt37A1 and UGT1A3

DIOPT Version :10

• Sequence 1: NP_523607.2
• Gene: Ugt37A1 / 35307
• FlyBaseID: FBgn0026756
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_061966.1
• Gene: UGT1A3 / 54659
• HGNCID: 12535
• Length: 534
• Species: Homo sapiens
• Alignment Length: 518
• Identity: 144/518 - (27%)
• Similarity: 242/518 - (46%)
• Gaps: 62/518 - (11%)

  Fly    37 SHLIISMSVAKILAEQGHNVTVVTVLEPTITHKNINLVT-----VPMTKEEIKQRSETIGAKQKN 96
            ||.:....|.:.|..:||...|:|. |..:..|..|..|     :..|::|..:  ..:|..|..
Human    39 SHWLSMREVLRELHARGHQAVVLTP-EVNMHIKEENFFTLTTYAISWTQDEFDR--HVLGHTQLY 100

  Fly    97 TSSNRFISILNMSGQMDSMLRKMADVLKDQRVKEL-------YLNKDNHFDLVISGYFMNDYQLG 154
            ..:..|:.....|   .:||..|:.|.....|:.|       :||..: ||:|::.. :|.....
Human   101 FETEHFLKKFFRS---MAMLNNMSLVYHRSCVELLHNEALIRHLNATS-FDVVLTDP-VNLCAAV 160

  Fly   155 FARKVNAPVVVL--------------APSPPSQMLNSLIGNPHDKVEKEKGMTFGQRLDSYISSL 205
            .|:.::.|.|..              .|:|.|.:...|..|       ...|||.||    :.::
Human   161 LAKYLSIPTVFFLRNIPCDLDFKGTQCPNPSSYIPRLLTTN-------SDHMTFMQR----VKNM 214

  Fly   206 LYGIFLRQIDQRNRQYY----NEIFGDDPTMPEYTDILRNTSLVFFCSHAASEGPIRPSVPAAIE 266
            ||.:.|..|.......|    :|:|..:.::   .|||.:.|:..|......:.| ||.:|..:.
Human   215 LYPLALSYICHAFSAPYASLASELFQREVSV---VDILSHASVWLFRGDFVMDYP-RPIMPNMVF 275

  Fly   267 IGGIQIKDKPDPLPKNLEKFLGNAT--HGAILLSLGSNVQGSHIKADTVKKIFSVLSNLKQRVIW 329
            ||||...:: .||.:..|.:: ||:  ||.::.||||.|  |.|.......|...|..:.|.|:|
Human   276 IGGINCANR-KPLSQEFEAYI-NASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLW 336

  Fly   330 KWDDLDKTPGKSDNILYSRWLPQDDILAHPSVKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPG 394
            ::.. .:....::|.:..:||||:|:|.||..:.||.|||..|:.|:..:|.||:.:|:||||..
Human   337 RYTG-TRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMD 400

  Fly   395 NAHAMVKSGFGLTLSLLTLEEEPFRAAVLEILSNPKYSQRVVKFSSLYRDRPASARESLIFWTEY 459
            ||..|...|.|:||::|.:..|....|:..::::..|.:.:::.|||::|||....:..:||.|:
Human   401 NAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEF 465

  Fly   460 VIRHHGAAHLQSPLVH-MDFIAANNLDIYALIGAISIGLLLMLKKVVQITCRRLRTKLNKVKK 521
            |:||.||.||: |..| :.:...::||:...:.|:.:.:..:..|......|:...|..:|||
Human   466 VMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKK 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	123/450 (27%)
UGT1A3	NP_061966.1	UDPGT	29..525	CDD:278624	141/514 (27%)