DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and UGT1A4

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_009051.1	Gene:	UGT1A4 / 54657	HGNCID:	12536	Length:	534	Species:	Homo sapiens

Alignment Length:	515	Identity:	137/515 - (26%)
Similarity:	242/515 - (46%)	Gaps:	65/515 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 MSVAKILAE---QGHNVTVVTVLEPTITHK-------NINLVTVPMTKEEIKQRSETIGAKQKNT 97
            :|:.:.|.|   :||...|:|   |.:...       .:....||.|::|..:  .|:|..|...
Human    42 LSMREALRELHARGHQAVVLT---PEVNMHIKEEKFFTLTAYAVPWTQKEFDR--VTLGYTQGFF 101

  Fly    98 SSNRFI-----SILNMSGQMDSMLRKMADVLKDQRVKELYLNKDNHFDLVISGYFMNDYQLGFAR 157
            .:...:     |:..|:....::.|...::|.::.:.. :||..: ||:|::.. :|......|:
Human   102 ETEHLLKRYSRSMAIMNNVSLALHRCCVELLHNEALIR-HLNATS-FDVVLTDP-VNLCGAVLAK 163

  Fly   158 KVNAPVVVL--------------APSPPSQMLNSLIGNPHDKVEKEKGMTFGQRLDSYISSLLYG 208
            .::.|.|..              .|:|.|.:...|..|       ...|||.||    :.::||.
Human   164 YLSIPAVFFWRYIPCDLDFKGTQCPNPSSYIPKLLTTN-------SDHMTFLQR----VKNMLYP 217

  Fly   209 IFLRQIDQRNRQYY----NEIFGDDPTMPEYTDILRNTSLVFFCSHAASEGPIRPSVPAAIEIGG 269
            :.|..|.......|    :|:|..:.::   .|::...|:..|......:.| ||.:|..:.|||
Human   218 LALSYICHTFSAPYASLASELFQREVSV---VDLVSYASVWLFRGDFVMDYP-RPIMPNMVFIGG 278

  Fly   270 IQIKDKPDPLPKNLEKFLGNAT--HGAILLSLGSNVQGSHIKADTVKKIFSVLSNLKQRVIWKWD 332
            |...: ..||.:..|.:: ||:  ||.::.||||.|  |.|.......|...|..:.|.|:|::.
Human   279 INCAN-GKPLSQEFEAYI-NASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYT 339

  Fly   333 DLDKTPGKSDNILYSRWLPQDDILAHPSVKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNAH 397
            . .:....::|.:..:||||:|:|.||..:.||.|||..|:.|:..:|.||:.:|:||||..||.
Human   340 G-TRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAK 403

  Fly   398 AMVKSGFGLTLSLLTLEEEPFRAAVLEILSNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVIR 462
            .|...|.|:||::|.:..|....|:..::::..|.:.:::.|||::|||....:..:||.|:|:|
Human   404 RMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMR 468

  Fly   463 HHGAAHLQSPLVH-MDFIAANNLDIYALIGAISIGLLLMLKKVVQITCRRLRTKLNKVKK 521
            |.||.||: |..| :.:...::||:...:.|:.:.:..:..|......|:...|..:|||
Human   469 HKGAPHLR-PAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	116/447 (26%)
UGT1A4	NP_009051.1	UDPGT	29..525	CDD:278624	134/511 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150629
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840