Protein Alignment Ugt37A1 and UGT1A9

DIOPT Version :10

• Sequence 1: NP_523607.2
• Gene: Ugt37A1 / 35307
• FlyBaseID: FBgn0026756
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_066307.1
• Gene: UGT1A9 / 54600
• HGNCID: 12541
• Length: 530
• Species: Homo sapiens
• Alignment Length: 531
• Identity: 149/531 - (28%)
• Similarity: 248/531 - (46%)
• Gaps: 50/531 - (9%)

  Fly    17 LLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLEPTITHK-------NINLV 74
            ||..|...|..|.:.| :..||.....||.:.|..:||.|.||.   |.::.:       .:...
Human    17 LLTCGFAEAGKLLVVP-MDGSHWFTMRSVVEKLILRGHEVVVVM---PEVSWQLGRSLNCTVKTY 77

  Fly    75 TVPMTKEEIKQRSETIGAKQKNTSSNRFISIL--NMSGQMDSMLRKMADVLKDQRVKELYLNKDN 137
            :...|.|::.:..:.....|.........|:|  :.:...|........:.||:::.| || |::
Human    78 STSYTLEDLDREFKAFAHAQWKAQVRSIYSLLMGSYNDIFDLFFSNCRSLFKDKKLVE-YL-KES 140

  Fly   138 HFDLVISGYFMNDYQLGFARKVNAPVVVLA--------------PSPPSQMLNSLIGNPHDKVEK 188
            .||.|....|.| ..|..|:..:.|.||.|              |:|.|.:...|:|       .
Human   141 SFDAVFLDPFDN-CGLIVAKYFSLPSVVFARGILCHYLEEGAQCPAPLSYVPRILLG-------F 197

  Fly   189 EKGMTFGQRLDSYISSLLYGIFLRQIDQRNRQYYNEIFGDDPTMPEYTDILRNTSLVFFCSHAAS 253
            ...|||.:|:.::|..|...:...:..:...:..:||.....|  || |:..:||:....:....
Human   198 SDAMTFKERVRNHIMHLEEHLLCHRFFKNALEIASEILQTPVT--EY-DLYSHTSIWLLRTDFVL 259

  Fly   254 EGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFLGNAT--HGAILLSLGSNVQGSHIKADTVKKI 316
            :.| :|.:|..|.||||.. .:..|||...|.:: ||:  ||.::.||||.|  |.|.......|
Human   260 DYP-KPVMPNMIFIGGINC-HQGKPLPMEFEAYI-NASGEHGIVVFSLGSMV--SEIPEKKAMAI 319

  Fly   317 FSVLSNLKQRVIWKWDDLDKTPGKSDNILYSRWLPQDDILAHPSVKLFINHAGKGGISEAQYHGK 381
            ...|..:.|.|:|::.. .:....::|.:..:||||:|:|.||..:.||.|||..|:.|:..:|.
Human   320 ADALGKIPQTVLWRYTG-TRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGV 383

  Fly   382 PMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRAAVLEILSNPKYSQRVVKFSSLYRDRP 446
            ||:.:|:||||..||..|...|.|:||::|.:..|....|:..::::..|.:.:::.|||::|||
Human   384 PMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRP 448

  Fly   447 ASARESLIFWTEYVIRHHGAAHLQSPLVH-MDFIAANNLDIYALIGAISIGLLLMLKKVVQITCR 510
            ....:..:||.|:|:||.||.||: |..| :.:...::||:...:.|:.:.:..:..|......|
Human   449 VEPLDLAVFWVEFVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYR 512

  Fly   511 RLRTKLNKVKK 521
            :...|..:|||
Human   513 KCLGKKGRVKK 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	125/455 (27%)
UGT1A9	NP_066307.1	UDPGT	26..521	CDD:278624	142/518 (27%)