Protein Alignment Ugt37A1 and UGT1A5

DIOPT Version :9

• Sequence 1: NP_523607.2
• Gene: Ugt37A1 / 35307
• FlyBaseID: FBgn0026756
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_061951.1
• Gene: UGT1A5 / 54579
• HGNCID: 12537
• Length: 534
• Species: Homo sapiens
• Alignment Length: 516
• Identity: 136/516 - (26%)
• Similarity: 242/516 - (46%)
• Gaps: 58/516 - (11%)

  Fly    37 SHLIISMSVAKILAEQGHNVTVVTVLEPTITHKNINLVT-----VPMTKEEIKQRSETIGAKQKN 96
            ||.:......:.|..:||.|.|:| ||..:..|..|..|     :..|::|..:.  .:|..|..
Human    39 SHWLSMREALRDLHARGHQVVVLT-LEVNMYIKEENFFTLTTYAISWTQDEFDRL--LLGHTQSF 100

  Fly    97 TSS-------NRFISILNMSGQMDSML-RKMADVLKDQR-VKELYLNKDNHFDLVISGYFMNDYQ 152
            ..:       :|.::|:|   .|..:: |...::|.::. ::.|:...   ||:|::..| :...
Human   101 FETEHLLMKFSRRMAIMN---NMSLIIHRSCVELLHNEALIRHLHATS---FDVVLTDPF-HLCA 158

  Fly   153 LGFARKVNAPVVVL--------------APSPPSQMLNSLIGNPHDKVEKEKGMTFGQRLDSYIS 203
            ...|:.::.|.|..              .|:|.|.:...|..|       ...|||.||:.:.:.
Human   159 AVLAKYLSIPAVFFLRNIPCDLDFKGTQCPNPSSYIPRLLTTN-------SDHMTFLQRVKNMLY 216

  Fly   204 SLLYGIFLRQIDQRNRQYYNEIFGDDPTMPEYTDILRNTSLVFFCSHAASEGPIRPSVPAAIEIG 268
            .|........:........:|:|..:.::   .|::.:.|:..|......:.| ||.:|..:.||
Human   217 PLALSYLCHAVSAPYASLASELFQREVSV---VDLVSHASVWLFRGDFVMDYP-RPIMPNMVFIG 277

  Fly   269 GIQIKDKPDPLPKNLEKFLGNAT--HGAILLSLGSNVQGSHIKADTVKKIFSVLSNLKQRVIWKW 331
            ||...: ..||.:..|.:: ||:  ||.::.||||.|  |.|.......|...|..:.|.|:|::
Human   278 GINCAN-GKPLSQEFEAYI-NASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRY 338

  Fly   332 DDLDKTPGKSDNILYSRWLPQDDILAHPSVKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNA 396
            .. .:....::|.:..:||||:|:|.||..:.||.|||..|:.|:..:|.||:.:|:||||..||
Human   339 TG-TRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNA 402

  Fly   397 HAMVKSGFGLTLSLLTLEEEPFRAAVLEILSNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVI 461
            ..|...|.|:||::|.:..|....|:..::::..|.:.:::.|||::|||....:..:||.|:|:
Human   403 KRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVM 467

  Fly   462 RHHGAAHLQSPLVH-MDFIAANNLDIYALIGAISIGLLLMLKKVVQITCRRLRTKLNKVKK 521
            ||.||.||: |..| :.:...::||:...:.|:.:.:..:..|......|:...|..:|||
Human   468 RHKGAPHLR-PAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKK 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	115/448 (26%)
UGT1A5	NP_061951.1	UDPGT	29..525	CDD:278624	133/512 (26%)
		egt	<262..508	CDD:223071	83/252 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150628
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840