DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A1 and UGT1A6

DIOPT Version :9

Sequence 1:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001063.2	Gene:	UGT1A6 / 54578	HGNCID:	12538	Length:	532	Species:	Homo sapiens

Alignment Length:	558	Identity:	149/558 - (26%)
Similarity:	253/558 - (45%)	Gaps:	93/558 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VIVLALTLLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLEPTITHKNINLV 74
            |..|||..::.|.:    |.:.|. ..||.:....:.::|:::||.: ||.|.|..:..|.....
Human    15 VFFLALWGMVVGDK----LLVVPQ-DGSHWLSMKDIVEVLSDRGHEI-VVVVPEVNLLLKESKYY 73

  Fly    75 T-----VPMTKEEIKQRSETIGAKQKNTSSNRFISILNMSGQMDSMLRKM----------ADVLK 124
            |     ||..:||:|.|.::.|       :|.|.....::.........|          ..:|:
Human    74 TRKIYPVPYDQEELKNRYQSFG-------NNHFAERSFLTAPQTEYRNNMIVIGLYFINCQSLLQ 131

  Fly   125 DQRVKELYLNKDNHFDLVIS------GYFMNDYQLGFARKVNAPVVVL--------------APS 169
            |:.....:  |::.||.:.:      |..:.:| ||.      |.|.|              :|.
Human   132 DRDTLNFF--KESKFDALFTDPALPCGVILAEY-LGL------PSVYLFRGFPCSLEHTFSRSPD 187

  Fly   170 PPSQMLNSLIGNPHDKVEKEKGMTFGQRLDSYISSLL-----YGIFLRQIDQRNRQYYNEIFGDD 229
            |.|.:       |....:....|||.||:.:::.:||     |.:|.:         |.|:  ..
Human   188 PVSYI-------PRCYTKFSDHMTFSQRVANFLVNLLEPYLFYCLFSK---------YEEL--AS 234

  Fly   230 PTMPEYTDIL---RNTSLVFFCSHAASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFLGNAT 291
            ..:....||:   :..|:.........|.| ||.:|..:.||||..|.:.| |.:..|.:: ||:
Human   235 AVLKRDVDIITLYQKVSVWLLRYDFVLEYP-RPVMPNMVFIGGINCKKRKD-LSQEFEAYI-NAS 296

  Fly   292 --HGAILLSLGSNVQGSHIKADTVKKIFSVLSNLKQRVIWKWDDLDKTPGKSDNILYSRWLPQDD 354
              ||.::.||||.|  |.|.......|...|..:.|.|:|::.. .:....::|.:..:||||:|
Human   297 GEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTG-TRPSNLANNTILVKWLPQND 358

  Fly   355 ILAHPSVKLFINHAGKGGISEAQYHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFR 419
            :|.||..:.||.|||..|:.|:..:|.||:.:|:||||..||..|...|.|:||::|.:..|...
Human   359 LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLE 423

  Fly   420 AAVLEILSNPKYSQRVVKFSSLYRDRPASARESLIFWTEYVIRHHGAAHLQSPLVH-MDFIAANN 483
            .|:..::::..|.:.:::.|||::|||....:..:||.|:|:||.||.||: |..| :.:...::
Human   424 NALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLR-PAAHDLTWYQYHS 487

  Fly   484 LDIYALIGAISIGLLLMLKKVVQITCRRLRTKLNKVKK 521
            ||:...:.|:.:.:..:..|......|:...|..:|||
Human   488 LDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	123/475 (26%)
UGT1A6	NP_001063.2	egt	15..506	CDD:223071	143/537 (27%)
UGT1A6	NP_001063.2	UDPGT	27..523	CDD:278624	141/542 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150662
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840