Protein Alignment Ugt37A1 and UGT1A10

DIOPT Version :9

• Sequence 1: NP_523607.2
• Gene: Ugt37A1 / 35307
• FlyBaseID: FBgn0026756
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_061948.1
• Gene: UGT1A10 / 54575
• HGNCID: 12531
• Length: 530
• Species: Homo sapiens
• Alignment Length: 534
• Identity: 149/534 - (27%)
• Similarity: 252/534 - (47%)
• Gaps: 56/534 - (10%)

  Fly    17 LLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLEPTIT---HKNINLV---- 74
            ||..|...|..|.:.| :..||.....||.:.|..:||.|.||.   |.::   .:::|..
Human    17 LLTCGFAEAGKLLVVP-MDGSHWFTMQSVVEKLILRGHEVVVVM---PEVSWQLERSLNCTVKTY 77

  Fly    75 TVPMTKEEIKQRSETIGAKQKNTSSNRFISIL--NMSGQMDSMLRKMADVLKDQRVKELYLNKDN 137
            :...|.|:..:........|....:....|:|  :.||.:|........:..|:::.| || |::
Human    78 STSYTLEDQNREFMVFAHAQWKAQAQSIFSLLMSSSSGFLDLFFSHCRSLFNDRKLVE-YL-KES 140

  Fly   138 HFDLVISGYFMNDYQ---LGFARKVNAPVVVL--------------APSPPSQMLNSLIGNPHDK 185
            .||.|    |::.:.   |..|:..:.|.||.              .|:|.|.:.|.|:|
Human   141 SFDAV----FLDPFDTCGLIVAKYFSLPSVVFTRGIFCHHLEEGAQCPAPLSYVPNDLLG----- 196

  Fly   186 VEKEKGMTFGQRLDSYISSLLYGIFLRQIDQRNRQYYNEIFGDDPTMPEYTDILRNTSLVFFCSH 250
              ....|||.:|:.::|..|...:|.:.:.:...:..:||.....|.   .|:..:||:....:.
Human   197 --FSDAMTFKERVWNHIVHLEDHLFCQYLFRNALEIASEILQTPVTA---YDLYSHTSIWLLRTD 256

  Fly   251 AASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFLGNAT--HGAILLSLGSNVQGSHIKADTV 313
            ...:.| :|.:|..|.||||.. .:..|||...|.:: ||:  ||.::.||||.|  |.|.....
Human   257 FVLDYP-KPVMPNMIFIGGINC-HQGKPLPMEFEAYI-NASGEHGIVVFSLGSMV--SEIPEKKA 316

  Fly   314 KKIFSVLSNLKQRVIWKWDDLDKTPGKSDNILYSRWLPQDDILAHPSVKLFINHAGKGGISEAQY 378
            ..|...|..:.|.|:|::.. .:....::|.:..:||||:|:|.||..:.||.|||..|:.|:..
Human   317 MAIADALGKIPQTVLWRYTG-TRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESIC 380

  Fly   379 HGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRAAVLEILSNPKYSQRVVKFSSLYR 443
            :|.||:.:|:||||..||..|...|.|:||::|.:..|....|:..::::..|.:.:::.|||::
Human   381 NGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHK 445

  Fly   444 DRPASARESLIFWTEYVIRHHGAAHLQSPLVH-MDFIAANNLDIYALIGAISIGLLLMLKKVVQI 507
            |||....:..:||.|:|:||.||.||: |..| :.:...::||:...:.|:.:.:..:..|....
Human   446 DRPVEPLDLAVFWVEFVMRHKGAPHLR-PAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAY 509

  Fly   508 TCRRLRTKLNKVKK 521
            ..|:...|..:|||
Human   510 GYRKCLGKKGRVKK 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	125/458 (27%)
UGT1A10	NP_061948.1	UDPGT	26..521	CDD:278624	142/521 (27%)
		egt	<258..504	CDD:223071	84/252 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150408
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840